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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author FINNPEC Consortium
dc.contributor.author GOPEC Consortium
dc.contributor.author Thorsteinsdottir, Unnur
dc.date.accessioned 2022-09-06T01:02:11Z
dc.date.available 2022-09-06T01:02:11Z
dc.date.issued 2020-12
dc.identifier.citation FINNPEC Consortium , GOPEC Consortium & Thorsteinsdottir , U 2020 , ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ' , Nature Communications , vol. 11 , no. 1 , 5976 . https://doi.org/10.1038/s41467-020-19733-6
dc.identifier.issn 2041-1723
dc.identifier.other 36966662
dc.identifier.other 0a4023b1-4990-47d1-bf80-49d6adc9f343
dc.identifier.other 85096579509
dc.identifier.other 33239696
dc.identifier.uri https://hdl.handle.net/20.500.11815/3423
dc.description Research leading to these results was conducted as part of the InterPregGen study, which received funding from the European Union Seventh Framework Programme under grant agreement no. 282540 and was supported by Wellcome Trust grant 098051. Some data used for the research were obtained from THL Biobank. We thank all study participants for their generous participation at THL Biobank. Part of this work was conducted using the UK Biobank Resource under application number 24711. A full list of acknowledgments appears in Supplementary Note 3. Publisher Copyright: © 2020, The Author(s).
dc.description.abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
dc.format.extent 1681868
dc.format.extent
dc.language.iso en
dc.relation info:eu-repo/grantAgreement/EC/FP7/282540
dc.relation.ispartofseries Nature Communications; 11(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Arfgengi
dc.subject Meðganga
dc.subject Háþrýstingur
dc.subject Genetic Predisposition to Disease
dc.subject Hypertension, Pregnancy-Induced / genetics
dc.subject Multifactorial Inheritance
dc.subject Pre-Eclampsia / genetics
dc.subject General Chemistry
dc.subject General Biochemistry,Genetics and Molecular Biology
dc.subject General Physics and Astronomy
dc.title Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1038/s41467-020-19733-6
dc.relation.url http://www.scopus.com/inward/record.url?scp=85096579509&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.school Health Sciences


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