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Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis


Title: Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis
Author: Neumann, Bjoern
Foerster, Sarah
Zhao, Chao
Bodini, Benedetta
Reich, Daniel S.
Bergles, Dwight E.
Káradóttir, Ragnhildur Þóra
Lubetzki, Catherine
Lairson, Luke L.
Zalc, Bernard
... 2 more authors Show all authors
Date: 2020-05-07
Language: English
Scope: 3
Department: Faculty of Medicine
Series: Cell Stem Cell; 26(5)
ISSN: 1934-5909
DOI: https://doi.org/10.1016/j.stem.2020.03.017
Subject: MS sjúkdómur; Molecular Medicine; Genetics; Cell Biology
URI: https://hdl.handle.net/20.500.11815/3374

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Citation:

Neumann , B , Foerster , S , Zhao , C , Bodini , B , Reich , D S , Bergles , D E , Káradóttir , R Þ , Lubetzki , C , Lairson , L L , Zalc , B , Stankoff , B & Franklin , R J M 2020 , ' Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis ' , Cell Stem Cell , vol. 26 , no. 5 , pp. 617-619 . https://doi.org/10.1016/j.stem.2020.03.017

Abstract:

Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

Description:

The authors acknowledge the following support: The UK Multiple Sclerosis Society (MS50 to R.T.K., C.Z., and R.J.M.F.), The Adelson Medical Research Foundation (D.S.R., D.E.B., and R.J.M.F.), Intramural Research Program of NINDS/NIH (D.S.R.), European Research Council (ERC) under the European Union Horizon 2020 Research and Innovation Program (771411 to R.T.K.), The Lister Institute (R.T.K.), and a core support grant from the Wellcome and MRC to the Wellcome-Medical Research Council Cambridge Stem Cell Institute (203151/Z/16/Z to R.T.K. and R.J.M.F.). Publisher Copyright: © 2020 Elsevier Inc.

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