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Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments

Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments


Title: Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments
Author: More, Simon
Bambidis, Vasileos
Benford, Diane
Bragard, Claude
Hernandez-Jerez, Antonio
Bennekou, Susanne Hougaard
Koutsoumanis, Kostas
Machera, Kyriaki
Naegeli, Hanspeter
Nielsen, Soren Saxmose
... 14 more authors Show all authors
Date: 2020-08-01
Language: English
Scope:
Department: Faculty of Food Science and Nutrition
Series: EFSA Journal; 18(8)
ISSN: 1831-4732
DOI: https://doi.org/10.2903/j.efsa.2020.6221
Subject: Epidemiological studies; evidence appraisal; exposure assessment; hazard characterisation; risk assessment; Faraldsfræði; Áhættugreining; Parasitology; Food Science; Microbiology; Animal Science and Zoology; Veterinary (miscellaneous); Plant Science
URI: https://hdl.handle.net/20.500.11815/3368

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Citation:

More , S , Bambidis , V , Benford , D , Bragard , C , Hernandez-Jerez , A , Bennekou , S H , Koutsoumanis , K , Machera , K , Naegeli , H , Nielsen , S S , Schlatter , J R , Schrenk , D , Silano , V , Turck , D , Younes , M , Fletcher , T , Greiner , M , Ntzani , E , Pearce , N , Vinceti , M , Ciccolallo , L , Georgiadis , M , Gervelmeyer , A & Halldorsson , T I 2020 , ' Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments ' , EFSA Journal , vol. 18 , no. 8 , e06221 . https://doi.org/10.2903/j.efsa.2020.6221

Abstract:

EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases of the different epidemiological study designs. It describes key epidemiological concepts relevant for evidence appraisal. Regarding study reliability, measures of association, exposure assessment, statistical inferences, systematic error and effect modification are explained. Regarding study relevance, the guidance describes the concept of external validity. The principles of appraising epidemiological studies are illustrated, and an overview of Risk of Bias (RoB) tools is given. A decision tree is developed to assist in the selection of the appropriate Risk of Bias tool, depending on study question, population and design. The customisation of the study appraisal process is explained, detailing the use of RoB tools and assessing the risk of bias in the body of evidence. Several examples of appraising experimental and observational studies using a Risk of Bias tool are annexed to the document to illustrate the application of the approach. This document constitutes a draft that will be applied in EFSA's assessments during a 1-year pilot phase and be revised and complemented as necessary. Before finalisation of the document, a public consultation will be launched.

Description:

Publisher Copyright: © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

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