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Childhood overweight and obesity and the risk of depression across the lifespan

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Gibson-Smith, Deborah
dc.contributor.author Halldorsson, Thorhallur I.
dc.contributor.author Bot, Mariska
dc.contributor.author Brouwer, Ingeborg A.
dc.contributor.author Visser, Marjolein
dc.contributor.author Thorsdottir, Inga
dc.contributor.author Birgisdottir, Bryndis E.
dc.contributor.author Gudnason, Vilmundur
dc.contributor.author Eiriksdottir, Gudny
dc.contributor.author Launer, Lenore J.
dc.contributor.author Harris, Tamara B.
dc.contributor.author Gunnarsdottir, Ingibjorg
dc.date.accessioned 2022-08-26T01:03:00Z
dc.date.available 2022-08-26T01:03:00Z
dc.date.issued 2020-01-21
dc.identifier.citation Gibson-Smith , D , Halldorsson , T I , Bot , M , Brouwer , I A , Visser , M , Thorsdottir , I , Birgisdottir , B E , Gudnason , V , Eiriksdottir , G , Launer , L J , Harris , T B & Gunnarsdottir , I 2020 , ' Childhood overweight and obesity and the risk of depression across the lifespan ' , BMC Pediatrics , vol. 20 , no. 1 , 25 . https://doi.org/10.1186/s12887-020-1930-8
dc.identifier.issn 1471-2431
dc.identifier.other PURE: 38449152
dc.identifier.other PURE UUID: 63eb4e58-6ee2-4c6a-b7e6-29b9f89edee1
dc.identifier.other Scopus: 85078173940
dc.identifier.uri https://hdl.handle.net/20.500.11815/3361
dc.description The Age, Gene/Environment Susceptibility-Reykjavik Study is funded by NIH contract N01-AG-12100, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The funding body did not take part neither in the design of the study, the data collection, the data analysis, nor the interpretation of data or in the writing of the manuscript. DGS, MB, MV, IB and IG were supported by the EU-MoodFood grant. Funding for this research is provided by EU FP7 MooDFOOD Project ‘Multi-country cOllaborative project on the rOle of Diet, FOod-related behaviour, and Obesity in the prevention of Depression’, Grant agreement no. 613598. Publisher Copyright: © 2020 The Author(s).
dc.description.abstract Background: Obesity has been longitudinally associated with depression but only few studies take a life course approach. This longitudinal study investigates whether being overweight or obese at age 8 and 13 years is associated with depressive symptoms more than 60 years later and whether this association is independent of late-life body mass index (BMI). We also investigated the association of being overweight/obese at age 8 or 13 years with ever having major depressive disorder (lifetime MDD). Method: This analysis is based on a sub-sample of 889 AGES-Reykjavik participants with measured BMI data from early life. Late-life depressive symptoms were measured with the Geriatric Depression Scale (GDS) and lifetime MDD was assessed at late-life using the Mini International Neuropsychiatric Interview. Logistic regression analysis was used to estimate the relationships between BMI (continuous and categorical) at age 8 or 13 years, and late-life depressive symptoms (measured as GDS ≥ 5) or lifetime MDD, adjusted for sex, education, physical activity, smoking status and alcohol use. In a separate model, additional adjustments were made for late-life BMI. Results: One hundred and one subjects (11%) had depressive symptoms at late-life (GDS ≥ 5), and 39 subjects (4.4%) had lifetime MDD. Being overweight or obese at age 8 or 13 years was not associated with higher depressive symptoms during late-life, irrespective of late-life BMI. Being overweight or obese at age 8 years, but not age 13 years was associated with an increased risk of lifetime MDD (Odds Ratio (OR) (95% confidence interval [CI]) for age 8 = 4.03[1.16-13.96]P = 0.03 and age 13 = 2.65[0.69-10.26] P = 0.16, respectively). Conclusion: Being overweight in childhood was associated with increased odds of lifetime MDD, although the magnitude of the risk is uncertain given the small numbers of participants with lifetime MDD. No clear association was observed between childhood and adolescent overweight/obesity and late-life depressive symptoms irrespective of late life BMI.
dc.language.iso en
dc.relation.ispartofseries BMC Pediatrics; 20(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Body mass index
dc.subject Childhood obesity
dc.subject Depressive symptoms
dc.subject Lifetime major depressive disorder
dc.subject Offita
dc.subject Börn
dc.subject Þunglyndi
dc.subject Pediatrics, Perinatology and Child Health
dc.title Childhood overweight and obesity and the risk of depression across the lifespan
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 31964368
dc.identifier.doi https://doi.org/10.1186/s12887-020-1930-8
dc.relation.url http://www.scopus.com/inward/record.url?scp=85078173940&partnerID=8YFLogxK
dc.contributor.department Faculty of Food Science and Nutrition
dc.contributor.department Other departments
dc.contributor.department Faculty of Medicine
dc.contributor.school Health Sciences

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