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Guidance Document on Scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals

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dc.contributor.author EFSA Scientific Committee
dc.date.accessioned 2022-08-24T01:02:40Z
dc.date.available 2022-08-24T01:02:40Z
dc.date.issued 2021-12
dc.identifier.citation EFSA Scientific Committee 2021 , ' Guidance Document on Scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals ' , EFSA Journal , vol. 19 , no. 12 , e07033 . https://doi.org/10.2903/j.efsa.2021.7033
dc.identifier.issn 1831-4732
dc.identifier.other PURE: 45109275
dc.identifier.other PURE UUID: cf3af3b2-a656-4c4a-b52f-41ace3f1aa51
dc.identifier.other Scopus: 85122157032
dc.identifier.uri https://hdl.handle.net/20.500.11815/3334
dc.description Publisher Copyright: © 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
dc.description.abstract This guidance document provides harmonised and flexible methodologies to apply scientific criteria and prioritisation methods for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals. In the context of EFSA’s risk assessments, the problem formulation step defines the chemicals to be assessed in the terms of reference usually through regulatory criteria often set by risk managers based on legislative requirements. Scientific criteria such as hazard-driven criteria can be used to group these chemicals into assessment groups. In this guidance document, a framework is proposed to apply hazard-driven criteria for grouping of chemicals into assessment groups using mechanistic information on toxicity as the gold standard where available (i.e. common mode of action or adverse outcome pathway) through a structured weight of evidence approach. However, when such mechanistic data are not available, grouping may be performed using a common adverse outcome. Toxicokinetic data can also be useful for grouping, particularly when metabolism information is available for a class of compounds and common toxicologically relevant metabolites are shared. In addition, prioritisation methods provide means to identify low-priority chemicals and reduce the number of chemicals in an assessment group. Prioritisation methods include combined risk-based approaches, risk-based approaches for single chemicals and exposure-driven approaches. Case studies have been provided to illustrate the practical application of hazard-driven criteria and the use of prioritisation methods for grouping of chemicals in assessment groups. Recommendations for future work are discussed.
dc.format.extent
dc.language.iso en
dc.relation.ispartofseries EFSA Journal; 19(12)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Áhættugreining
dc.subject Efnafræði
dc.subject Parasitology
dc.subject Food Science
dc.subject Microbiology
dc.subject Animal Science and Zoology
dc.subject Veterinary (miscellaneous)
dc.subject Plant Science
dc.title Guidance Document on Scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.2903/j.efsa.2021.7033
dc.relation.url http://www.scopus.com/inward/record.url?scp=85122157032&partnerID=8YFLogxK
dc.contributor.department Faculty of Food Science and Nutrition


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