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Effect of doxycycline microencapsulation on buccal films : Stability, mucoadhesion and in vitro drug release

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dc.contributor.author Patlolla, Venu Gopal Reddy
dc.contributor.author Popovic, Nikolina
dc.contributor.author Peter Holbrook, William
dc.contributor.author Kristmundsdottir, Thordis
dc.contributor.author Gizurarson, Sveinbjörn
dc.date.accessioned 2022-06-25T01:01:47Z
dc.date.available 2022-06-25T01:01:47Z
dc.date.issued 2021-04-28
dc.identifier.citation Patlolla , V G R , Popovic , N , Peter Holbrook , W , Kristmundsdottir , T & Gizurarson , S 2021 , ' Effect of doxycycline microencapsulation on buccal films : Stability, mucoadhesion and in vitro drug release ' , Gels , vol. 7 , no. 2 , 51 . https://doi.org/10.3390/gels7020051
dc.identifier.issn 2310-2861
dc.identifier.other PURE: 39539730
dc.identifier.other PURE UUID: eed82e6e-f9b6-4611-8543-057092883d43
dc.identifier.other Scopus: 85106653160
dc.identifier.other unpaywall: 10.3390/gels7020051
dc.identifier.uri https://hdl.handle.net/20.500.11815/3262
dc.description Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This research was funded by Rannsóknarsjóður Háskóla Íslands (University of Iceland Research Grand).
dc.description.abstract The aim of this work was to stabilize doxycycline in mucoadhesive buccal films at room temperature (25◦C). Since doxycycline is susceptible to degradation such as oxidation and epimerization, tablets are currently the only formulation that can keep the drug fully stable at room temperature, while liquid formulations are limited to refrigerated conditions (4◦C). In this study, the aim was to make formulations containing subclinical (antibiotic) doxycycline concentration that can act as matrix metalloproteinase inhibitors (MMPI) and can be stored at temperatures such as 25◦C. Here, doxycycline was complexed with excipients using three techniques and entrapped into microparticles that were stored at 4◦C, 25◦C and 40◦C. Effect of addition of precomplexed doxycycline microparticles on films: stability mucoadhesion capacity, tensile strength, swelling index and in vitro release was studied. The complexation efficiency between drug-excipients, microparticles and films was studied using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Two of the films were found to be stable at 4◦C but the film containing microparticle composed of precomplexed doxycycline with β-cyclodextrin, MgCl2, sodium thiosulfate, HPMC and Eudragit® RS 12.5 was found to be stable at 25◦C until 26 weeks. The addition of microparticles to the films was found to reduce the mucoadhesive capacity, peak detachment force, tensile strength and elasticity, but improved the stability at room temperature.
dc.language.iso en
dc.relation.ispartofseries Gels; 7(2)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Doxycycline
dc.subject Film
dc.subject Matrix metalloproteinase inhibitor
dc.subject Microparticles
dc.subject MMPI
dc.subject Bioengineering
dc.subject Biomaterials
dc.subject Organic Chemistry
dc.subject Polymers and Plastics
dc.title Effect of doxycycline microencapsulation on buccal films : Stability, mucoadhesion and in vitro drug release
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 33924744
dc.identifier.doi https://doi.org/10.3390/gels7020051
dc.relation.url http://www.scopus.com/inward/record.url?scp=85106653160&partnerID=8YFLogxK
dc.contributor.department Faculty of Pharmaceutical Sciences

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