Opin vísindi

Symmetry breaking and effects of nutrient walkway in time-dependent bone remodeling incorporating poroelasticity

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Esposito, L
dc.contributor.author Minutolo, V
dc.contributor.author Gargiulo, P
dc.contributor.author Fraldi, M
dc.date.accessioned 2022-06-14T01:02:51Z
dc.date.available 2022-06-14T01:02:51Z
dc.date.issued 2022-04-08
dc.identifier.citation Esposito , L , Minutolo , V , Gargiulo , P & Fraldi , M 2022 , ' Symmetry breaking and effects of nutrient walkway in time-dependent bone remodeling incorporating poroelasticity ' , Biomechanics and Modeling in Mechanobiology , vol. 21 , no. 3 , pp. 999-1020 . https://doi.org/10.1007/s10237-022-01573-6
dc.identifier.issn 1617-7959
dc.identifier.other PURE: 50813865
dc.identifier.other PURE UUID: 5113d3b3-d0e0-4596-9296-3a1a3fff305f
dc.identifier.other Scopus: 85127635806
dc.identifier.other unpaywall: 10.1007/s10237-022-01573-6
dc.identifier.uri https://hdl.handle.net/20.500.11815/3241
dc.description Funding Information: The Authors need to thank the anonymous Reviewer(s) for their careful reading and helpful suggestions, which lead to significant improvements of the work. MF gratefully acknowledges the support of the grants by the Italian Ministry of Education, University and Research (MIUR) through the grants PRIN-20177TTP3S and PON-ARS01-01384. This manuscript was also conducted under the auspicious of the GNFM-INDAM. Funding Information: The Authors need to thank the anonymous Reviewer(s) for their careful reading and helpful suggestions, which lead to significant improvements of the work. MF gratefully acknowledges the support of the grants by the Italian Ministry of Education, University and Research (MIUR) through the grants PRIN-20177TTP3S and PON-ARS01-01384. This manuscript was also conducted under the auspicious of the GNFM-INDAM. Publisher Copyright: © 2022, The Author(s).
dc.description.abstract Bone is an extraordinary biological material that continuously adapts its hierarchical microstructure to respond to static and dynamic loads for offering optimal mechanical features, in terms of stiffness and toughness, across different scales, from the sub-microscopic constituents within osteons-where the cyclic activity of osteoblasts, osteoclasts, and osteocytes redesigns shape and percentage of mineral crystals and collagen fibers-up to the macroscopic level, with growth and remodeling processes that modify the architecture of both compact and porous bone districts. Despite the intrinsic complexity of the bone mechanobiology, involving coupling phenomena of micro-damage, nutrients supply driven by fluid flowing throughout hierarchical networks, and cells turnover, successful models and numerical algorithms have been presented in the literature to predict, at the macroscale, how bone remodels under mechanical stimuli, a fundamental issue in many medical applications such as optimization of femur prostheses and diagnosis of the risk fracture. Within this framework, one of the most classical strategies employed in the studies is the so-called Stanford's law, which allows uploading the effect of the time-dependent load-induced stress stimulus into a biomechanical model to guess the bone structure evolution. In the present work, we generalize this approach by introducing the bone poroelasticity, thus incorporating in the model the role of the fluid content that, by driving nutrients and contributing to the removal of wastes of bone tissue cells, synergistically interacts with the classical stress fields to change homeostasis states, local saturation conditions, and reorients the bone density rate, in this way affecting growth and remodeling. Through two paradigmatic example applications, i.e. a cylindrical slice with internal prescribed displacements idealizing a tract of femoral diaphysis pushed out by the pressure exerted by a femur prosthesis and a bone element in a form of a bent beam, it is highlighted that the present model is capable to catch more realistically both the transition between spongy and cortical regions and the expected non-symmetrical evolution of bone tissue density in the medium-long term, unpredictable with the standard approach. A real study case of a femur is also considered at the end in order to show the effectiveness of the proposed remodeling algorithm.
dc.format.extent 22
dc.format.extent 999-1020
dc.language.iso en
dc.relation.ispartofseries Biomechanics and Modeling in Mechanobiology; 21(3)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Vísindadeild
dc.subject Biomechanical Phenomena
dc.subject Bone Density
dc.subject Bone Remodeling
dc.subject Femur
dc.subject Models, Biological
dc.subject Nutrients
dc.subject Stress, Mechanical
dc.subject Porous media
dc.subject Bone tissue
dc.subject Poroelasticity
dc.subject Fluid flow
dc.subject Bone remodeling
dc.subject Mechanical Engineering
dc.subject Biotechnology
dc.subject Modeling and Simulation
dc.title Symmetry breaking and effects of nutrient walkway in time-dependent bone remodeling incorporating poroelasticity
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35394267
dc.identifier.doi https://doi.org/10.1007/s10237-022-01573-6
dc.relation.url http://www.scopus.com/inward/record.url?scp=85127635806&partnerID=8YFLogxK
dc.contributor.department Department of Engineering
dc.contributor.department Other departments


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