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Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders : an International Myeloma Working Group Mass Spectrometry Committee Report

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Murray, David L.
dc.contributor.author Puig, Noemi
dc.contributor.author Kristinsson, Sigurður Yngvi
dc.contributor.author Usmani, Saad Z.
dc.contributor.author Dispenzieri, Angela
dc.contributor.author Bianchi, Giada
dc.contributor.author Kumar, Shaji
dc.contributor.author Chng, Wee Joo
dc.contributor.author Hajek, Roman
dc.contributor.author Paiva, Bruno
dc.contributor.author Waage, Anders
dc.contributor.author Rajkumar, S. Vincent
dc.contributor.author Durie, Brian
dc.date.accessioned 2022-06-10T01:02:10Z
dc.date.available 2022-06-10T01:02:10Z
dc.date.issued 2021-02-01
dc.identifier.citation Murray , D L , Puig , N , Kristinsson , S Y , Usmani , S Z , Dispenzieri , A , Bianchi , G , Kumar , S , Chng , W J , Hajek , R , Paiva , B , Waage , A , Rajkumar , S V & Durie , B 2021 , ' Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders : an International Myeloma Working Group Mass Spectrometry Committee Report ' , Blood Cancer Journal , vol. 11 , no. 2 , 24 , pp. 24 . https://doi.org/10.1038/s41408-021-00408-4
dc.identifier.issn 2044-5385
dc.identifier.other PURE: 38140982
dc.identifier.other PURE UUID: b55e5378-4831-4fa6-9ad0-7031527e8d8c
dc.identifier.other Scopus: 85101033511
dc.identifier.other WOS: 000620220000001
dc.identifier.other unpaywall: 10.1038/s41408-021-00408-4
dc.identifier.uri https://hdl.handle.net/20.500.11815/3229
dc.description Publisher Copyright: © 2021, The Author(s).
dc.description.abstract Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect and isotype M-proteins. Increasing demands to detect low-level disease and new therapeutic monoclonal immunoglobulin treatments have stretched the electrophoretic methods to their analytical limits. Newer techniques based on mass spectrometry (MS) are emerging which have improved clinical and analytical performance. MS is gaining traction into clinical laboratories, and has replaced immunofixation electrophoresis (IFE) in routine practice at one institution. The International Myeloma Working Group (IMWG) Mass Spectrometry Committee reviewed the literature in order to summarize current data and to make recommendations regarding the role of mass spectrometric methods in diagnosing and monitoring patients with myeloma and related disorders. Current literature demonstrates that immune-enrichment of immunoglobulins coupled to intact light chain MALDI-TOF MS has clinical characteristics equivalent in performance to IFE with added benefits of detecting additional risk factors for PCDs, differentiating M-protein from therapeutic antibodies, and is a suitable replacement for IFE for diagnosing and monitoring multiple myeloma and related PCDs. In this paper we discuss the IMWG recommendations for the use of MS in PCDs.
dc.format.extent 24
dc.language.iso en
dc.relation.ispartofseries Blood Cancer Journal; 11(2)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Mergæxli
dc.subject Krabbamein
dc.subject Sjúkdómsgreining
dc.subject Chromatography, Liquid/methods
dc.subject Humans
dc.subject Immunoglobulin Light Chains/analysis
dc.subject Multiple Myeloma/diagnosis
dc.subject Myeloma Proteins/analysis
dc.subject Neoplasms, Plasma Cell/diagnosis
dc.subject Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
dc.title Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders : an International Myeloma Working Group Mass Spectrometry Committee Report
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 33563895
dc.identifier.doi https://doi.org/10.1038/s41408-021-00408-4
dc.relation.url http://www.scopus.com/inward/record.url?scp=85101033511&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Cancer Center


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