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HOMEFOOD randomised trial - Six-month nutrition therapy improves quality of life, self-rated health, cognitive function, and depression in older adults after hospital discharge

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Blondal, B S
dc.contributor.author Geirsdottir, O G
dc.contributor.author Halldorsson, T I
dc.contributor.author Beck, A M
dc.contributor.author Jónsson, Pálmi V
dc.contributor.author Ramel, A
dc.date.accessioned 2022-06-02T01:03:39Z
dc.date.available 2022-06-02T01:03:39Z
dc.date.issued 2022-04-01
dc.identifier.citation Blondal , B S , Geirsdottir , O G , Halldorsson , T I , Beck , A M , Jónsson , P V & Ramel , A 2022 , ' HOMEFOOD randomised trial - Six-month nutrition therapy improves quality of life, self-rated health, cognitive function, and depression in older adults after hospital discharge ' , Clinical Nutrition ESPEN , vol. 48 , pp. 74-81 . https://doi.org/10.1016/j.clnesp.2022.01.010
dc.identifier.issn 2405-4577
dc.identifier.other PURE: 49600232
dc.identifier.other PURE UUID: d35fc00b-34a7-404c-8c44-f8fd780088ff
dc.identifier.other Scopus: 85123889647
dc.identifier.other unpaywall: 10.1016/j.clnesp.2022.01.010
dc.identifier.other ORCID: /0000-0002-3766-2062/work/114651799
dc.identifier.uri https://hdl.handle.net/20.500.11815/3220
dc.description Funding Information: The authors want to thank the study staff for their dedicated work, i.e. Ósk Guðmundsdóttir, Elfa Björk Rúnarsdóttir, and Gunnhildur Olga Jónsdóttir as well as the Icelandic food companies Sláturfélag Suðurlands Ltd. Grimur kokkur Ltd. and MS Iceland Dairies for the collaboration and delivery of food items. The authors want to state that neither the above-mentioned funding entities nor the food companies were involved in study design, -conduct, statistical analysis, or paper writing. The authors want to thank Prof. Karl Heinz Wagner from the University of Vienna for critical review of the manuscript. Funding Information: The study was funded by the Icelandic Research Fund (174,250–051), the research Fund of the University of Iceland, the research fund of Hrafnista, the Icelandic Society of Geriatrics, and the Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund. The grants were provided without any conditions. Publisher Copyright: © 2022 The Authors
dc.description.abstract Background and aims: Malnutrition is common among older adults and is related to quality of life, cognitive function, and depression. To what extent nutrition interventions can improve these outcomes remains unclear. The aim of this study was to investigate the effect of nutrition therapy on health-related quality of life (EQ-5D), self-rated health, cognitive function, and depression in community dwelling older adults recently discharged from hospital. Methods: Participants (>65 years) were randomised into an intervention (n = 53) and a control group (n = 53). The intervention group received individualised nutrition therapy based on the nutrition care process including 5 home visits and 3 phone calls, in combination with freely delivered energy- and protein-rich foods and oral nutrition supplements for six months after hospital discharge. EQ-5D, self-rated health, Mini-Mental-State-Examination (MMSE), and the Centre for Epidemiologic Studies Depression – IOWA (CES-D) scale were measured at baseline and at endpoint. Results: Two subjects dropped out, one from each arm. The control group experienced an increase in depressive symptoms and a decrease in self-rated health during the study period, while the intervention group experienced increases in cognitive function, self-rated health, and EQ-5D resulting in significant endpoint differences between the groups: EQ-5D (0.102, P = 0.001); self-rated health: 15.876 (P < 0.001); MMSE: 1.701 (P < 0.001); depressive symptoms: - 3.072 (P < 0.001); all in favour of the intervention group. Improvements during the intervention in MMSE, self-rated health, and CES-D were significantly related to body weight gain in a linear way. Conclusion: Cognitive function and mental well-being worsen or stagnate in older adults who receive standard care after hospital discharge. However, a six-month nutrition therapy improves these outcomes leading to statistically and clinically significant endpoint differences between the groups. As improvements were related to body weight gain after hospital discharge, we conclude that the increase in dietary intake, with focus on energy and protein density, and changes in body weight might have contributed to better cognitive function and mental well-being in older adults after the intervention.
dc.format.extent 8
dc.format.extent 74-81
dc.language.iso en
dc.relation.ispartofseries Clinical Nutrition ESPEN; 48()
dc.rights info:eu-repo/semantics/openAccess
dc.subject Næringarfræði
dc.subject Öldrunarlæknisfræði
dc.subject Aldraðir
dc.subject Aged
dc.subject Cognition
dc.subject Depression/psychology
dc.subject Hospitals
dc.subject Humans
dc.subject Nutrition Therapy
dc.subject Patient Discharge
dc.subject Quality of Life/psychology
dc.subject Oral nutrition supplements
dc.subject Self-rated health
dc.subject Nutrition status
dc.subject Food
dc.subject Nutrition and Dietetics
dc.subject Endocrinology, Diabetes and Metabolism
dc.subject SDG 3 - Good Health and Well-being
dc.title HOMEFOOD randomised trial - Six-month nutrition therapy improves quality of life, self-rated health, cognitive function, and depression in older adults after hospital discharge
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35331537
dc.identifier.doi https://doi.org/10.1016/j.clnesp.2022.01.010
dc.relation.url http://www.scopus.com/inward/record.url?scp=85123889647&partnerID=8YFLogxK
dc.relation.url http://www.scopus.com/inward/record.url?eid=2-s2.0-85123889647&partnerID=MN8TOARS
dc.contributor.department Faculty of Food Science and Nutrition
dc.contributor.department Faculty of Medicine
dc.contributor.department Geriatric and Rehabilitation Services


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