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Retinal oximetry with a prototype handheld oximeter during hyperoxia

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Vehmeijer, Wouter B.
dc.contributor.author Jonkman, Kelly
dc.contributor.author Harðarson, Sveinn Hákon
dc.contributor.author Aarts, Leon
dc.contributor.author Stefánsson, Einar
dc.contributor.author Dahan, Albert
dc.contributor.author Schalij-Delfos, Nicoline E.
dc.date.accessioned 2022-06-02T01:02:01Z
dc.date.available 2022-06-02T01:02:01Z
dc.date.issued 2021-03-01
dc.identifier.citation Vehmeijer , W B , Jonkman , K , Harðarson , S H , Aarts , L , Stefánsson , E , Dahan , A & Schalij-Delfos , N E 2021 , ' Retinal oximetry with a prototype handheld oximeter during hyperoxia ' , Acta Ophthalmologica , vol. 99 , no. 8 , pp. e1390-e1395 . https://doi.org/10.1111/aos.14817
dc.identifier.issn 1755-375X
dc.identifier.other PURE: 38301775
dc.identifier.other PURE UUID: 1d1ee2db-b750-40a8-ad85-636a81df1287
dc.identifier.other Scopus: 85101849005
dc.identifier.other unpaywall: 10.1111/aos.14817
dc.identifier.other WOS: 000623662800001
dc.identifier.uri https://hdl.handle.net/20.500.11815/3216
dc.description Publisher Copyright: © 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
dc.description.abstract Purpose: Retinal oximetry measures oxygen saturation in retinal vessels. With the introduction of a mobile handheld prototype oximeter, this technique will become available for a broader patient population including bedridden patients and newborn babies. The objective is to determine the sensitivity of this handheld oximeter in room air and during isocapnic hyperoxia. A comparison is made between the handheld oximeter and the Oxymap T1. Methods: Thirteen young healthy subjects with a mean age of 25 ± 2 years were recruited at the Leiden University Medical Center. Retinal oximetry images were acquired during normoxia and during isocapnic hyperoxia for both the prototype oximeter and the OxymapT1. Isocapnic hyperoxia was induced with the dynamic end-tidal forcing technique. For both oximeters, the oxygen saturation and vessel width were measured with Oxymap Analyzer software. The hyperoxic state was verified with blood gas analysis. Results: The mean oxygen saturation measured with the handheld oximeter in arterioles was 91.3% ± 3.9% during normoxia and 94.6% ± 3.9% during hyperoxia (p = 0.001). Oxygen saturation in venules was 56.3% ± 9.8% during normoxia and 82.2 ± 7.4% during hyperoxia (p < 0.001). For the Oxymap T1, the mean oxygen saturation for arterioles was 94.0% ± 2.6% during normoxia and 95.4%±3.2% during hyperoxia (p = 0.004). For the venules, the oxygen saturation was during normoxia 58.9%±3.2% and 84.3 ± 4.0% during hyperoxia (p < 0.001). Conclusion: The handheld retinal oximeter is sensitive to the changes in inhaled oxygen concentration. A small increase in oxygen saturation was measured in the arterioles and a larger increase in the venules. The handheld oximeter gives similar values as the ‘gold standard’ Oxymap T1 oximeter.
dc.format.extent e1390-e1395
dc.language.iso en
dc.relation.ispartofseries Acta Ophthalmologica; 99(8)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Sjónhimna
dc.subject Súrefni
dc.subject Mælingar
dc.subject Lófatölvur
dc.subject fundus imaging
dc.subject handheld oximeter
dc.subject hyperoxia
dc.subject retinal oximetry
dc.subject Ophthalmology
dc.title Retinal oximetry with a prototype handheld oximeter during hyperoxia
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1111/aos.14817
dc.relation.url http://www.scopus.com/inward/record.url?scp=85101849005&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Other departments


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