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The international Perinatal Outcomes in the Pandemic (iPOP) study : Protocol

The international Perinatal Outcomes in the Pandemic (iPOP) study : Protocol

Title: The international Perinatal Outcomes in the Pandemic (iPOP) study : Protocol
Author: iPOP Study Team
Einarsdóttir, Kristjana
Date: 2021
Language: English
Scope: 1982365
Department: Faculty of Medicine
Faculty of Nursing and Midwifery
Series: Wellcome Open Research; 6()
ISSN: 2398-502X
DOI: 10.12688/wellcomeopenres.16507.1
Subject: Fæðing; Fyrirburar; COVID-19; COVID-19; Global trends; Low birth weight; Pandemic lockdowns; Perinatal outcomes; Preterm birth; Stillbirth; Medicine (miscellaneous); General Biochemistry,Genetics and Molecular Biology
URI: https://hdl.handle.net/20.500.11815/3210

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iPOP Study Team & Einarsdóttir , K 2021 , ' The international Perinatal Outcomes in the Pandemic (iPOP) study : Protocol ' , Wellcome Open Research , vol. 6 , 21 , pp. 21 . https://doi.org/10.12688/wellcomeopenres.16507.1


Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread 'natural experiment' of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.


Grant information: iPOP was established with funding from International COVID Data Alliance (ICODA) and Health Data Research (HDR) UK. This seed funding will be leveraged to secure additional funding to support ongoing operations and expansion of the iPOP Study. Sarah Stock is supported by a Wellcome Trust Clinical Career Development Fellowship (209560/Z/17/Z) and Health Data Research UK, during the conduct of this work. Helga Zoega is supported by a UNSW Scientia Fellowship. Meredith Brockway receives salary funding from the Molly Towell Perinatal Research Foundation. Meghan Azad holds the Canada Research Chair in the Developmental Origins of Chronic Disease and is a Fellow of the CIFAR Humans and the Microbiome Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2021 Stock SJ et al.

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