dc.contributor.author | Ahluwalia, Tarunveer S. |
dc.contributor.author | Prins, Bram P. |
dc.contributor.author | Abdollahi, Mohammadreza |
dc.contributor.author | Armstrong, Nicola J. |
dc.contributor.author | Aslibekyan, Stella |
dc.contributor.author | Bain, Lisa |
dc.contributor.author | Jefferis, Barbara |
dc.contributor.author | Baumert, Jens |
dc.contributor.author | Beekman, Marian |
dc.contributor.author | Ben-Shlomo, Yoav |
dc.contributor.author | Bis, Joshua C. |
dc.contributor.author | Mitchell, Braxton D. |
dc.contributor.author | De Geus, Eco |
dc.contributor.author | Delgado, Graciela E. |
dc.contributor.author | Marek, Diana |
dc.contributor.author | Eriksson, Joel |
dc.contributor.author | Kajantie, Eero |
dc.contributor.author | Kanoni, Stavroula |
dc.contributor.author | Kemp, John P. |
dc.contributor.author | Lu, Chen |
dc.contributor.author | Marioni, Riccardo E. |
dc.contributor.author | McLachlan, Stela |
dc.contributor.author | Milaneschi, Yuri |
dc.contributor.author | Nolte, Ilja M. |
dc.contributor.author | Petrelis, Alexandros M. |
dc.contributor.author | Porcu, Eleonora |
dc.contributor.author | Sabater-Lleal, Maria |
dc.contributor.author | Naderi, Elnaz |
dc.contributor.author | Seppälä, Ilkka |
dc.contributor.author | Shah, Tina |
dc.contributor.author | Singhal, Gaurav |
dc.contributor.author | Standl, Marie |
dc.contributor.author | Teumer, Alexander |
dc.contributor.author | Thalamuthu, Anbupalam |
dc.contributor.author | Thiering, Elisabeth |
dc.contributor.author | Trompet, Stella |
dc.contributor.author | Ballantyne, Christie M. |
dc.contributor.author | Benjamin, Emelia J. |
dc.contributor.author | Casas, Juan P. |
dc.contributor.author | Toben, Catherine |
dc.contributor.author | Dedoussis, George |
dc.contributor.author | Deelen, Joris |
dc.contributor.author | Durda, Peter |
dc.contributor.author | Engmann, Jorgen |
dc.contributor.author | Feitosa, Mary F. |
dc.contributor.author | Grallert, Harald |
dc.contributor.author | Hammarstedt, Ann |
dc.contributor.author | Harris, Sarah E. |
dc.contributor.author | Homuth, Georg |
dc.contributor.author | Guðnason, Vilmundur G. |
dc.date.accessioned | 2022-05-05T01:01:59Z |
dc.date.available | 2022-05-05T01:01:59Z |
dc.date.issued | 2021-01-30 |
dc.identifier.citation | Ahluwalia , T S , Prins , B P , Abdollahi , M , Armstrong , N J , Aslibekyan , S , Bain , L , Jefferis , B , Baumert , J , Beekman , M , Ben-Shlomo , Y , Bis , J C , Mitchell , B D , De Geus , E , Delgado , G E , Marek , D , Eriksson , J , Kajantie , E , Kanoni , S , Kemp , J P , Lu , C , Marioni , R E , McLachlan , S , Milaneschi , Y , Nolte , I M , Petrelis , A M , Porcu , E , Sabater-Lleal , M , Naderi , E , Seppälä , I , Shah , T , Singhal , G , Standl , M , Teumer , A , Thalamuthu , A , Thiering , E , Trompet , S , Ballantyne , C M , Benjamin , E J , Casas , J P , Toben , C , Dedoussis , G , Deelen , J , Durda , P , Engmann , J , Feitosa , M F , Grallert , H , Hammarstedt , A , Harris , S E , Homuth , G & Guðnason , V G 2021 , ' Genome-wide association study of circulating interleukin 6 levels identifies novel loci ' , Human Molecular Genetics , vol. 30 , no. 5 , pp. 393-409 . https://doi.org/10.1093/hmg/ddab023 |
dc.identifier.issn | 0964-6906 |
dc.identifier.other | 35633518 |
dc.identifier.other | 0d4ddb7a-ee79-4625-aefd-bb05ff1c4c9d |
dc.identifier.other | 85106143662 |
dc.identifier.other | 33517400 |
dc.identifier.other | unpaywall: 10.1093/hmg/ddab023 |
dc.identifier.uri | https://hdl.handle.net/20.500.11815/3131 |
dc.description | Funding Novo Nordisk Foundation (NNF18OC0052457 to T.S.A.). Detailed Funding statements from participating study cohorts can be found in Supplementary Material, Table S12. Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press. |
dc.description.abstract | Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology. |
dc.format.extent | 17 |
dc.format.extent | 1381772 |
dc.format.extent | 393-409 |
dc.language.iso | en |
dc.relation.ispartofseries | Human Molecular Genetics; 30(5) |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Ónæmisfræði |
dc.subject | Erfðafræði |
dc.subject | Sameindalíffræði |
dc.subject | Cohort Studies |
dc.subject | Gene Expression Regulation |
dc.subject | Genetic Loci |
dc.subject | Genetic Predisposition to Disease |
dc.subject | Genome-Wide Association Study |
dc.subject | HLA-DRB1 Chains/genetics |
dc.subject | Humans |
dc.subject | Interleukin 1 Receptor Antagonist Protein/genetics |
dc.subject | Interleukin-1/genetics |
dc.subject | Interleukin-6/blood |
dc.subject | Polymorphism, Single Nucleotide |
dc.subject | Receptors, Interleukin-6/genetics |
dc.subject | Whites/genetics |
dc.subject | Genetics (clinical) |
dc.subject | Genetics |
dc.subject | Molecular Biology |
dc.title | Genome-wide association study of circulating interleukin 6 levels identifies novel loci |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version | Peer reviewed |
dc.identifier.doi | 10.1093/hmg/ddab023 |
dc.relation.url | http://www.scopus.com/inward/record.url?scp=85106143662&partnerID=8YFLogxK |
dc.contributor.department | Faculty of Medicine |