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Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study

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dc.contributor.author Westerlind, Helga
dc.contributor.author Palmqvist, Ida
dc.contributor.author Saevarsdottir, Saedis
dc.contributor.author Alfredsson, Lars
dc.contributor.author Klareskog, Lars
dc.contributor.author Di Giuseppe, Daniela
dc.date.accessioned 2022-04-30T01:02:48Z
dc.date.available 2022-04-30T01:02:48Z
dc.date.issued 2021-08-07
dc.identifier.citation Westerlind , H , Palmqvist , I , Saevarsdottir , S , Alfredsson , L , Klareskog , L & Di Giuseppe , D 2021 , ' Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study ' , Arthritis Research and Therapy , vol. 23 , no. 1 , 209 , pp. 209 . https://doi.org/10.1186/s13075-021-02583-y
dc.identifier.issn 1478-6354
dc.identifier.other PURE: 39232756
dc.identifier.other PURE UUID: 16899c85-887d-45f1-8875-a3f8f129228e
dc.identifier.other Scopus: 85112627272
dc.identifier.other WOSLite: 000682485400001
dc.identifier.other unpaywall: 10.1186/s13075-021-02583-y
dc.identifier.uri https://hdl.handle.net/20.500.11815/3108
dc.description The study received support from Karolinska Institutet Foundations and grants. The funder had no role in any parts of the project. Open Access funding provided by Karolinska Institute. Publisher Copyright: © 2021, The Author(s).
dc.description.abstract BACKGROUND: Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, is not well studied and results are conflicting. METHODS: We collected data on tea consumption for 2237 incident RA cases diagnosed 2005-2018 and 4661 controls matched on age, sex, and residential area. Tea consumption was classified into no (0 cups/day), irregular (< 1 cup/day), regular (1-2 cups/day), and high (≥ 2 cups/day) consumption, and irregular consumption was used as the reference category. Missing data on tea consumption was classified as no consumers, and sensitivity analyses were performed to test this assumption. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression, adjusting for smoking, coffee, alcohol, educational level, and body mass index. We also performed stratified analysis on sex, anti-citrullinated autoantibody (ACPA) status, and smoking habits. RESULTS: Among the cases, we found 57.3% to be ever consumers of tea with 19.7 having a high tea consumption. Corresponding figures for the controls were 58.4% ever drinkers with 22.1% high tea consumers. High tea consumption had an inverse association to the risk of RA compared to irregular consumption [OR = 0.78 (95% CI 0.66-0.92)], but the association lost statistical significance in the adjusted model [adjusted OR (adjOR) = 0.85 (95% CI 0.71-1.01)]. Among non-tea consumers, a protective effect was also observed compared to irregular consumers [adjOR = 0.82 (95% CI 0.70-0.88)], but this association did not withstand sensitivity analysis, possibly due to bias. In the ACPA-positive group and among current smokers, a protective effect of tea consumption was observed among the high tea consumers [adjOR = 0.76 (95% CI 0.62-0.94) and adjOR = 0.60 (95% CI 0.38-0.95), respectively]. CONCLUSIONS: This study suggests a protective effect of high consumption of tea, among smokers and for ACPA-positive RA. TRIAL REGISTRATION: Not applicable.
dc.format.extent 209
dc.language.iso en
dc.relation.ispartofseries Arthritis Research and Therapy; 23(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Áhættuþættir
dc.subject Iktsýki
dc.subject Te
dc.subject ACPA
dc.subject Diet
dc.subject Rheumatoid arthritis
dc.subject Risk
dc.subject Smoking
dc.subject Tea
dc.subject Sweden
dc.subject Humans
dc.subject Risk Factors
dc.subject Arthritis, Rheumatoid/epidemiology
dc.subject Case-Control Studies
dc.subject Rheumatology
dc.subject Immunology and Allergy
dc.subject Immunology
dc.title Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 34362418
dc.identifier.doi https://doi.org/10.1186/s13075-021-02583-y
dc.relation.url http://www.scopus.com/inward/record.url?scp=85112627272&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine

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