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Loss of a co-twin at birth and subsequent risk of psychiatric disorders

Loss of a co-twin at birth and subsequent risk of psychiatric disorders


Title: Loss of a co-twin at birth and subsequent risk of psychiatric disorders
Author: Song, Huan
Fang, Fang
Larsson, Henrik
Pedersen, Nancy L.
Magnusson, Patrik K.E.
Almqvist, Catarina
Valdimarsdóttir, Unnur A.
Date: 2021-01-28
Language: English
Scope: 12
Department: Faculty of Medicine
Series: eLife; 10()
ISSN: 2050-084X
DOI: https://doi.org/10.7554/eLife.63514
Subject: Tvíburar; Geðraskanir; Burðarmálsdauði; Twin Pregnancy; Emotional Disorder; Mental Disease; Sibling; Cohort analysis; Neuroscience (all); Biochemistry, Genetics and Molecular Biology (all); Immunology and Microbiology (all)
URI: https://hdl.handle.net/20.500.11815/3073

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Citation:

Song , H , Fang , F , Larsson , H , Pedersen , N L , Magnusson , P K E , Almqvist , C & Valdimarsdóttir , U A 2021 , ' Loss of a co-twin at birth and subsequent risk of psychiatric disorders ' , eLife , vol. 10 , e63514 , pp. 1-12 . https://doi.org/10.7554/eLife.63514

Abstract:

Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birth between 1973 and 2011 (n = 787) to that of 3935 matched unexposed twins, 3935 matched singletons (both matched to the exposed twins by birth year, sex, and birth characteristics), and 880 full siblings of the exposed twins. During a median of 19-year follow-up, exposed twins were at increased risk of first-onset psychiatric disorders (hazard ratio = 1.56, 95%CI 1.30–1.87) compared with unexposed twins. We observed the strongest association for emotional disorders and for psychiatric disorders diagnosed before the age of 25. Comparisons with matched singletons and the twin’s full siblings rendered similar results, corroborating an association of loss of a co-twin at birth with subsequent risk of psychiatric disorders.

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© 2021, Song et al.

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