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Copeptin is associated with mortality in elderly people

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dc.contributor.author Smaradottir, Maria Isabel
dc.contributor.author Andersen, Karl
dc.contributor.author Gudnason, Vilmundur
dc.contributor.author Näsman, Per
dc.contributor.author Rydén, Lars
dc.contributor.author Mellbin, Linda Garcia
dc.date.accessioned 2022-04-23T01:02:09Z
dc.date.available 2022-04-23T01:02:09Z
dc.date.issued 2021-07
dc.identifier.citation Smaradottir , M I , Andersen , K , Gudnason , V , Näsman , P , Rydén , L & Mellbin , L G 2021 , ' Copeptin is associated with mortality in elderly people ' , European Journal of Clinical Investigation , vol. 51 , no. 7 , e13516 , pp. e13516 . https://doi.org/10.1111/eci.13516
dc.identifier.issn 0014-2972
dc.identifier.other PURE: 38445413
dc.identifier.other PURE UUID: ee79e6ad-5d8f-459e-bcb1-db1f6258cb18
dc.identifier.other Scopus: 85100905812
dc.identifier.uri https://hdl.handle.net/20.500.11815/3071
dc.description © 2021 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
dc.description.abstract BACKGROUND: Elevated copeptin, a marker for vasopressin release, has been associated with impaired prognosis in acute myocardial infarction (MI). The aim was to investigate whether this association extends beyond the acute phase and whether it is related to markers of stress (cortisol) and heart failure (NTproBNP). METHODS: Copeptin, cortisol and NTproBNP were measured in 926 participants (age: 76.0; male: 48.5%) in the ICELAND MI study whereof 246 had a previous MI (91 recognizable (RMI) and 155 previously unrecognizable (UMI) detected by cardiac magnetic resonance imaging). The primary endpoint was cardiovascular events (CVEs), and secondary endpoints were total mortality, heart failure and MI (median follow-up was 9.1 years). The relation between copeptin and prognosis was assessed with the Cox proportional hazard regression (unadjusted, adjusted for cortisol and NTproBNP, respectively, and a multiple model: copeptin, cortisol, NTproBNP, age, sex, serum creatinine, heart failure). RESULTS: Copeptin was higher in participants with MI (8.9 vs. 6.4 pmol/L; P < .01), with no difference between RMI vs. UMI. Increased copeptin correlated with evening cortisol (r = .11; P < .01) and NTproBNP (r = .07; P = .04). Copeptin was associated with CVE and total mortality after adjusting for cortisol and NTproBNP separately, and remained significantly associated with total mortality in the multiple model. CONCLUSIONS: Copeptin was higher in subjects with previous MI regardless whether previously recognized or not. Copeptin correlated weakly with cortisol and NTproBNP, and was independently associated with total mortality. This indicates that the prognostic implications of copeptin are not only mediated by heart failure or stress, supporting the assumption that copeptin is a marker of general vulnerability.
dc.format.extent e13516
dc.language.iso en
dc.relation.ispartofseries European Journal of Clinical Investigation; 51(7)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Hormónar
dc.subject Dánartíðni
dc.subject Amínósýrur
dc.subject Hjartadrep
dc.subject copeptin
dc.subject cortisol
dc.subject myocardial infarction
dc.subject NTproBNP
dc.subject unknown myocardial infarction
dc.subject vasopressin
dc.subject Heart Failure/epidemiology
dc.subject Recurrence
dc.subject Cardiovascular Diseases/mortality
dc.subject Prognosis
dc.subject Humans
dc.subject Mortality
dc.subject Proportional Hazards Models
dc.subject Male
dc.subject Hydrocortisone/blood
dc.subject Glycopeptides/blood
dc.subject Myocardial Infarction/blood
dc.subject Aged, 80 and over
dc.subject Female
dc.subject Stroke/epidemiology
dc.subject Aged
dc.subject Peptide Fragments/blood
dc.subject Myocardial Revascularization/statistics & numerical data
dc.subject Natriuretic Peptide, Brain/blood
dc.subject Biochemistry
dc.subject Clinical Biochemistry
dc.title Copeptin is associated with mortality in elderly people
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 33569762
dc.identifier.doi https://doi.org/10.1111/eci.13516
dc.relation.url http://www.scopus.com/inward/record.url?scp=85100905812&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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