Opin vísindi

Cognitive effects of montelukast : A pharmaco-eeg study

Cognitive effects of montelukast : A pharmaco-eeg study


Title: Cognitive effects of montelukast : A pharmaco-eeg study
Author: Schwimmbeck, Fabian
Staffen, Wolfgang
Höhn, Christopher
Rossini, Fabio
Renz, Nora
Lobendanz, Markus
Reichenpfader, Peter
Iglseder, Bernhard
Aigner, Ludwig
Trinka, Eugen
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Date: 2021-05
Language: English
Scope:
School: School of Humanities
Series: Brain Sciences; 11(5)
ISSN: 2076-3425
DOI: https://doi.org/10.3390/brainsci11050547
Subject: Taugavísindi; Heilinn; Lyf; Anti-inflammatory drug; Cognitive tests; EEG; Leukotriene receptor antagonist; Montelukast; Neuroscience (all)
URI: https://hdl.handle.net/20.500.11815/2980

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Citation:

Schwimmbeck , F , Staffen , W , Höhn , C , Rossini , F , Renz , N , Lobendanz , M , Reichenpfader , P , Iglseder , B , Aigner , L , Trinka , E & Höller , Y 2021 , ' Cognitive effects of montelukast : A pharmaco-eeg study ' , Brain Sciences , vol. 11 , no. 5 , 547 . https://doi.org/10.3390/brainsci11050547

Abstract:

 
Montelukast is a well-established antiasthmatic drug with little side effects. It is a leukotriene receptor antagonist and recent research suggests cognitive benefits from its anti-inflammatory actions on the central nervous system. However, changes in brain activity were not directly shown so far in humans. This study aims to document changes in brain activity that are associated with cognitive improvement during treatment with Montelukast. We recorded EEG and conducted neuropsychological tests in 12 asthma-patients aged 38–73 years before and after 8 weeks of treatment with Montelukast. We found no significant changes on neuropsychological scales for memory, attention, and mood. In the EEG, we found decreased entropy at follow up during rest (p < 0.005). During episodic memory acquisition we found decreased entropy (p < 0.01) and acceleration of the background rhythm (p < 0.05). During visual attention performance, we detected an increase in gamma power (p < 0.005) and slowing of the background rhythm (p < 0.05). The study is limited by its small sample size, young age and absence of baseline cognitive impairment of the participants. Unspecific changes in brain activity were not accompanied by cognitive improvement. Future studies should examine elderly patients with cognitive impairment in a double-blind study with longer-term treatment by Montelukast.
 
Montelukast is a well-established antiasthmatic drug with little side effects. It is a leukotriene receptor antagonist and recent research suggests cognitive benefits from its anti-inflammatory actions on the central nervous system. However, changes in brain activity were not directly shown so far in humans. This study aims to document changes in brain activity that are associated with cognitive improvement during treatment with Montelukast. We recorded EEG and conducted neuropsychological tests in 12 asthma-patients aged 38–73 years before and after 8 weeks of treatment with Montelukast. We found no significant changes on neuropsychological scales for memory, attention, and mood. In the EEG, we found decreased entropy at follow up during rest (p < 0.005). During episodic memory acquisition we found decreased entropy (p < 0.01) and acceleration of the background rhythm (p < 0.05). During visual attention performance, we detected an increase in gamma power (p < 0.005) and slowing of the background rhythm (p < 0.05). The study is limited by its small sample size, young age and absence of baseline cognitive impairment of the participants. Unspecific changes in brain activity were not accompanied by cognitive improvement. Future studies should examine elderly patients with cognitive impairment in a double-blind study with longer-term treatment by Montelukast.
 

Description:

Funding Information: Funding: This research was funded by the research fund of the Paracelsus Medical University, grant number R-16/02/078-HIS. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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