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Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018

Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018


Title: Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018
Author: Möller, Vidar
Östholm-Balkhed, Åse
Berild, Dag
Fredriksson, Mats
Gottfreðsson, Magnús
Holmbom, Martin
Järvinen, Asko
Kristjánsson, Már
Rydell, Ulf
Sönksen, Ute Wolff
... 2 more authors Show all authors
Date: 2021-05-10
Language: English
Scope: 12
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Medicine
Other departments
Internal Medicine and Emergency Services
Series: Infectious Diseases; 53(8)
ISSN: 2374-4235
DOI: https://doi.org/10.1080/23744235.2021.1910338
Subject: Fræðsluefni; Sýklalyfjaónæmi; Norðurlönd; Norðurlönd; Antibiotic resistance; antibiotic stewardship; Nordic countries; practice guidelines as topic; Humans; Norway/epidemiology; Anti-Bacterial Agents/pharmacology; Methicillin-Resistant Staphylococcus aureus; Finland/epidemiology; Drug Resistance, Microbial; Sweden; Hospitals; Iceland/epidemiology; Microbiology (medical); Infectious Diseases; Immunology and Microbiology (all)
URI: https://hdl.handle.net/20.500.11815/2942

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Citation:

Möller , V , Östholm-Balkhed , Å , Berild , D , Fredriksson , M , Gottfreðsson , M , Holmbom , M , Järvinen , A , Kristjánsson , M , Rydell , U , Sönksen , U W , Kolmos , H J & Hanberger , H 2021 , ' Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 ' , Infectious Diseases , vol. 53 , no. 8 , pp. 607-618 . https://doi.org/10.1080/23744235.2021.1910338

Abstract:

BACKGROUND: The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment and antibiotic use in Nordic countries 2010-2018. METHODS: Antibiotic resistance among invasive isolates from 2010-2018 and aggregated antibiotic use were obtained from the European Centre for Disease Prevention and Control. Hospital practice guidelines were obtained from national or regional guidelines. RESULTS: Antibiotic resistance levels among Escherichia coli and Klebsiella pneumoniae were similar in all Nordic countries in 2018 and low compared to the European mean. Guidelines for acute pyelonephritis varied; 2nd generation cephalosporin (Finland), 3rd generation cephalosporins (Sweden, Norway), ampicillin with an aminoglycoside or aminoglycoside monotherapy (Denmark, Iceland and Norway). Corresponding guidelines for sepsis of unknown origin were 2nd (Finland) or 3rd (Sweden, Norway, Iceland) generation cephalosporins, carbapenems, (Sweden) combinations of penicillin with an aminoglycoside (Norway, Denmark), or piperacillin-tazobactam (all Nordic countries). Methicillin-resistant Staphylococcus aureus rates were 0-2% and empirical treatment with anti-MRSA antibiotics was not recommended in any country. Rates of penicillin non-susceptibility among Streptococcus pneumoniae were low (<10%) except in Finland and Iceland (<15%), but benzylpenicillin was recommended for community-acquired pneumonia in all countries. CONCLUSION: Despite similar resistance rates among Enterobacteriaceae there were differences in practice guidelines for pyelonephritis and sepsis. National surveillance of antibiotic resistance can be used for comparison and optimization of guidelines and stewardship interventions to preserve the low levels of antibiotic resistance in Nordic countries.

Description:

This work has been made possible by funding from Region Östergötland and VINNOVA Sweden's innovation agency. Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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