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Risk of specific cardiovascular diseases in obsessive-compulsive disorder

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dc.contributor.author Isomura, Kayoko
dc.contributor.author Sidorchuk, Anna
dc.contributor.author Brander, Gustaf
dc.contributor.author Jernberg, Tomas
dc.contributor.author Rück, Andreas
dc.contributor.author Song, Huan
dc.contributor.author Valdimarsdóttir, Unnur Anna
dc.contributor.author Lichtenstein, Paul
dc.contributor.author Larsson, Henrik
dc.contributor.author Rück, Christian
dc.contributor.author Mataix-Cols, David
dc.contributor.author Fernández de la Cruz, Lorena
dc.date.accessioned 2022-03-05T01:01:36Z
dc.date.available 2022-03-05T01:01:36Z
dc.date.issued 2021-03
dc.identifier.citation Isomura , K , Sidorchuk , A , Brander , G , Jernberg , T , Rück , A , Song , H , Valdimarsdóttir , U A , Lichtenstein , P , Larsson , H , Rück , C , Mataix-Cols , D & Fernández de la Cruz , L 2021 , ' Risk of specific cardiovascular diseases in obsessive-compulsive disorder ' , Journal of Psychiatric Research , vol. 135 , pp. 189-196 . https://doi.org/10.1016/j.jpsychires.2020.12.066
dc.identifier.issn 0022-3956
dc.identifier.other PURE: 38462628
dc.identifier.other PURE UUID: be6d22ac-2dde-47f5-8498-350acf419ef2
dc.identifier.other Scopus: 85099921465
dc.identifier.uri https://hdl.handle.net/20.500.11815/2928
dc.description This work was supported by grants from Region Stockholm, Stockholm Health Care Services (ALF project, grant number 20180078), the Swedish Medical Association [Svenska Läkaresällskapet] (grant reference SLS-879801), and Karolinska Institutet (grant reference FS-2018:0007) awarded to Dr. Fernández de la Cruz. Publisher Copyright: © 2020 The Author(s)
dc.description.abstract Individuals with obsessive-compulsive disorder (OCD) may have an increased risk of cardiovascular disease (CVD), but evidence for specific types of CVD is limited. This population-based, sibling-controlled cohort study investigated the risk of specific CVD in individuals with OCD. Linking data from various Swedish population-based registers, we explored the risk of a range of CVD in a cohort of individuals diagnosed with OCD between 1973 and 2013 (n = 33,561), compared to matched (1:10) unaffected individuals (n = 335,610). Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using conditional Cox proportional hazards regression models, adjusting for history of somatic diseases. To control for familial confounders, we analyzed 23,263 clusters of full siblings discordant for OCD. Individuals with psychiatric comorbidities were systematically excluded to assess the impact of these comorbidities. Over an average follow-up time of 27 years, OCD was associated with an increased risk of a broad range of CVD (adjusted HR [aHR] for any CVD = 1.25 [95% confidence interval [CI], 1.22–1.29]). These associations were strongest for the subtypes venous thrombo-embolism (aHR = 1.48 [95% CI, 1.38–1.58]) and heart failure (aHR = 1.37 [95% CI, 1.28–1.46]). When comparing OCD-exposed individuals with their non-exposed full siblings, results were largely similar. Exclusion of several groups of psychiatric comorbidities resulted in comparable results, albeit attenuated. Individuals with OCD have a moderately increased risk of CVD-related morbidity, independent from history of somatic diseases, familial confounders, and psychiatric comorbidities. The time may be ripe for the development and evaluation of lifestyle interventions to help reduce the risk of cardiovascular morbidity in OCD.
dc.format.extent 8
dc.format.extent 189-196
dc.language.iso en
dc.relation.ispartofseries Journal of Psychiatric Research; 135()
dc.rights info:eu-repo/semantics/openAccess
dc.subject Áráttu- og þráhyggjuröskun
dc.subject Hjartasjúkdómar
dc.subject Cardiovascular disease
dc.subject Cohort study
dc.subject Morbidity
dc.subject Obsessive-compulsive disorder
dc.subject Quasi-experimental design
dc.subject Sibling comparison
dc.subject Obsessive-Compulsive Disorder/epidemiology
dc.subject Cardiovascular Diseases/epidemiology
dc.subject Humans
dc.subject Sweden/epidemiology
dc.subject Cohort Studies
dc.subject Siblings
dc.subject Psychiatry and Mental Health
dc.subject Biological Psychiatry
dc.title Risk of specific cardiovascular diseases in obsessive-compulsive disorder
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 33493948
dc.identifier.doi https://doi.org/10.1016/j.jpsychires.2020.12.066
dc.relation.url http://www.scopus.com/inward/record.url?scp=85099921465&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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