Opin vísindi

Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality : Age Gene/Environment Susceptibility-Reykjavik Study

Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality : Age Gene/Environment Susceptibility-Reykjavik Study


Title: Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality : Age Gene/Environment Susceptibility-Reykjavik Study
Author: Hino, Takuya
Hida, Tomoyuki
Nishino, Mizuki
Lu, Junwei
Putman, Rachel K.
Guðmundsson, Elías Freyr
Hata, Akinori
Araki, Tetsuro
Valtchinov, Vladimir I.
Honda, Osamu
... 16 more authors Show all authors
Date: 2021-03-10
Language: English
Scope: 100334
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Medicine
Internal Medicine and Emergency Services
Series: European Journal of Radiology Open; 8()
ISSN: 2352-0477
DOI: https://doi.org/10.1016/j.ejro.2021.100334
Subject: Lungnasjúkdómar; Lungnatrefjun; Lungnatrefjun; Berkjubólga; Lungnabólga; Age Gene/Environment Susceptibility-Reykjavik Study; Interstitial lung abnormality; Pulmonary fibrosis; Traction bronchiectasis; Usual interstitial pneumonia; Radiology, Nuclear Medicine and Imaging
URI: https://hdl.handle.net/20.500.11815/2917

Show full item record

Citation:

Hino , T , Hida , T , Nishino , M , Lu , J , Putman , R K , Guðmundsson , E F , Hata , A , Araki , T , Valtchinov , V I , Honda , O , Yanagawa , M , Yamada , Y , Kamitani , T , Jinzaki , M , Tomiyama , N , Ishigami , K , Honda , H , San Jose Estepar , R , Washko , G R , Johkoh , T , Christiani , D C , Lynch , D A , Guðnason , V G , Guðmundsson , G , Hunninghake , G M & Hatabu , H 2021 , ' Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality : Age Gene/Environment Susceptibility-Reykjavik Study ' , European Journal of Radiology Open , vol. 8 , 100334 , pp. 100334 . https://doi.org/10.1016/j.ejro.2021.100334

Abstract:

Purpose: The aim of this study is to assess the role of traction bronchiectasis/bronchiolectasis and its progression as a predictor for early fibrosis in interstitial lung abnormalities (ILA). Methods: Three hundred twenty-seven ILA participants out of 5764 in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study who had undergone chest CT twice with an interval of approximately five-years were enrolled in this study. Traction bronchiectasis/bronchiolectasis index (TBI) was classified on a four-point scale: 0, ILA without traction bronchiectasis/bronchiolectasis; 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; 2, ILA with mild to moderate traction bronchiectasis; 3, ILA and severe traction bronchiectasis and/or honeycombing. Traction bronchiectasis (TB) progression was classified on a five-point scale: 1, Improved; 2, Probably improved; 3, No change; 4, Probably progressed; 5, Progressed. Overall survival (OS) among participants with different TB Progression Score and between the TB progression group and No TB progression group was also investigated. Hazard radio (HR) was estimated with Cox proportional hazards model. Results: The higher the TBI at baseline, the higher TB Progression Score (P < 0.001). All five participants with TBI = 3 at baseline progressed; 46 (90 %) of 51 participants with TBI = 2 progressed. TB progression was also associated with shorter OS with statistically significant difference (adjusted HR = 1.68, P < 0.001). Conclusion: TB progression was visualized on chest CT frequently and clearly. It has the potential to be the predictor for poorer prognosis of ILA.

Description:

Funding text Dr. Nishino reports personal fees from Daiichi Sankyo, from AstraZeneca, grants from Merck investigator studies program, grants from Canon Medical Systems, grants from AstraZeneca, grants from Daiichi Sankyo, personal fees from Roche, outside the submitted work. Publisher Copyright: © 2021 The Author(s)

Files in this item

This item appears in the following Collection(s)