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Gagnsemi serum-tryptasamælinga hjá sjúklingum með möguleg einkenni bráðaofnæmiskasts á bráðamóttöku 2011-2018

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dc.contributor.author Hansen, Karólína
dc.contributor.author Björnsson, Hjalti Már
dc.contributor.author Gunnbjörnsdóttir, María I.
dc.date.accessioned 2022-02-23T01:02:29Z
dc.date.available 2022-02-23T01:02:29Z
dc.date.issued 2021-10
dc.identifier.citation Hansen , K , Björnsson , H M & Gunnbjörnsdóttir , M I 2021 , ' Gagnsemi serum-tryptasamælinga hjá sjúklingum með möguleg einkenni bráðaofnæmiskasts á bráðamóttöku 2011-2018 ' , Læknablaðið , bind. 107 , nr. 10 , bls. 470-475 . https://doi.org/10.17992/lbl.2021.10.656
dc.identifier.issn 0023-7213
dc.identifier.other 42827721
dc.identifier.other 0d097dcf-74fc-4a9d-8ac8-7acc9dbca74d
dc.identifier.other 85117322562
dc.identifier.other 34585673
dc.identifier.other unpaywall: 10.17992/lbl.2021.10.656
dc.identifier.uri https://hdl.handle.net/20.500.11815/2912
dc.description Publisher Copyright: © 2021 Laeknafelag Islands. All rights reserved.
dc.description.abstract Background Diagnosing anaphylaxis is often straightforward but can be challenging if the presentation is atypical. In patients with atypical symptoms suspected to be due to an acute allergic reaction, s-tryptase can give additional diagnostic information. Measuring s-tryptase is also helpful in diagnosing mastocytosis. Obtaining s-tryptase levels has been done in the emergency department (ED) at Landspitali since 2011. The aim of this study was to evaluate the benefit of obtaining s-tryptase levels in the ED. Methods With institutional review board approval, all cases where s-tryptase level was obtained in ED patients from 2011-2018 were retrospectively reviewed. A database was collected including information on patient demographics, presenting symptoms, treatment, diagnosis, s-tryptase level and follow up. Results A total of 214 patients had a s-tryptase level measured. Serum tryptase was elevated (>12 μg/L) in 36 cases. Females were 131 and average age 40.6 years. Of the patients, 86.4% had skin or mucosal symptoms, 48.1% cardiovascular symptoms, 49.5% respiratory symptoms and 36.0% had gastrointestinal symptoms. An allergist reviewed 126 returning patients and 65 were considered to have had an episode of anaphylaxis. Of those 65 were 4 patients which did not meet the diagnostic criteria for anaphylaxis but had raised s-tryptase levels. Sensitivity of s-tryptase measurement was 40.9% and specificity 97.1%. Conclusions Obtaining a s-tryptase level from ED patients with possible anaphylaxis seems to be useful in atypical cases. The measurement is specific but not sensitive. No cases of mastocytosis were identified in the patient cohort.
dc.format.extent 6
dc.format.extent 752411
dc.format.extent 470-475
dc.language.iso is
dc.relation.ispartofseries Læknablaðið; 107(10)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Sjúkdómsgreining
dc.subject Bráðadeildir
dc.subject Bráðaofnæmi
dc.subject Anaphylaxis
dc.subject Emergency Department
dc.subject Mastocytosis
dc.subject Serum tryptase
dc.subject Adult
dc.subject Anaphylaxis/diagnosis
dc.subject Emergency Service, Hospital
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Retrospective Studies
dc.subject Tryptases
dc.subject Almenn læknisfræði
dc.title Gagnsemi serum-tryptasamælinga hjá sjúklingum með möguleg einkenni bráðaofnæmiskasts á bráðamóttöku 2011-2018
dc.title.alternative Utility of serum tryptase in Emergency Department patients with possible anaphylaxis
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.17992/lbl.2021.10.656
dc.relation.url http://www.scopus.com/inward/record.url?scp=85117322562&partnerID=8YFLogxK
dc.contributor.department Læknadeild
dc.contributor.department Lyflækninga- og bráðaþjónusta

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