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Breytingar í lungnavef á tölvusneiðmyndum sjúklinga með kórónuveirusjúkdóm 2019 (COVID-19)

Breytingar í lungnavef á tölvusneiðmyndum sjúklinga með kórónuveirusjúkdóm 2019 (COVID-19)


Title: Breytingar í lungnavef á tölvusneiðmyndum sjúklinga með kórónuveirusjúkdóm 2019 (COVID-19)
Alternative Title: Parenchymal lung changes on CT in patients with coronavirus disease 2019 (COVID-19)
Author: Halldórsson, Arnljótur Björn
Axelsson, Gísli Þór
Jónsson, Helgi Már
Ísaksson, Jóhann Davíð
Harðardóttir, Hrönn
Guðmundsson, Gunnar
Hansdóttir, Sif
Date: 2021-10
Language: Icelandic
Scope: 9
Department: Læknadeild
Lyflækninga- og bráðaþjónusta
Series: Læknablaðið; 107(10)
ISSN: 0023-7213
DOI: https://doi.org/10.17992/lbl.2021.10.655
Subject: COVID-19; Sneiðmyndatökur; Lungnabólga; (CT) scan; Computed Tomography; COVID-19; pneumonia; Adult; Age Factors; Aged; COVID-19/diagnostic imaging; Databases, Factual; Female; Hospitalization; Host-Pathogen Interactions; Humans; Iceland; Lung/diagnostic imaging; Male; Middle Aged; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; SARS-CoV-2/pathogenicity; Severity of Illness Index; Sex Factors; Tomography, X-Ray Computed; Læknisfræði (allt)
URI: https://hdl.handle.net/20.500.11815/2911

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Citation:

Halldórsson , A B , Axelsson , G Þ , Jónsson , H M , Ísaksson , J D , Harðardóttir , H , Guðmundsson , G & Hansdóttir , S 2021 , ' Breytingar í lungnavef á tölvusneiðmyndum sjúklinga með kórónuveirusjúkdóm 2019 (COVID-19) ' , Læknablaðið , bind. 107 , nr. 10 , bls. 460-468 . https://doi.org/10.17992/lbl.2021.10.655

Abstract:

Introduction Infections due to COVID-19 can lead to life threatening pneumonia. Accompanying severe disease are more prominent pulmonary changes on Computed Tomography (CT) scan of the chest. The goal of this study was to describe pulmonary CT changes during acute COVID-19 and at follow up and whether the extent of changes correlate with severity of illness, demographics or other risk factors. Materials and methods Included in this study are all individuals that had confirmed COVID-19 and came for a follow up CT of the chest at Landspitali from May to September 2020. Information regarding medical history was obtained retrospectively from medical charts. All CT scans were reviewed using an international staging system to evaluate the extent of lung changes. Results Eighty-five patients with a mean age of 59 years were included in the study. Sixty patients (71%) were hospitalized during the acute phase and 18 (21%) were admitted to the ICU. During the acute phase more pronounced lung involvement was seen in males and patients admitted to the ICU. At follow-up females had less lung involvement but there was a significant relationship between a higher CT score and age, ICU admissions and days in the ICU. Full recovery was seen at follow-up CT in 31% of patients (median 68,5 days between acute and follow-up imaging). Conclusion Patients with severe COVID-19 have more pronounced lung involvement on CT than patients with milder disease during the acute phase and follow-up. Older patients and males are at greater risk of acute and persistent COVID-19 related lung changes.

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