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Changes in antibiotic prescribing following COVID-19 restrictions : Lessons for post-pandemic antibiotic stewardship

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dc.contributor.author Gillies, Malcolm B.
dc.contributor.author Burgner, David P.
dc.contributor.author Ivancic, Lorraine
dc.contributor.author Nassar, Natasha
dc.contributor.author Miller, Jessica E.
dc.contributor.author Sullivan, Sheena G.
dc.contributor.author Todd, Isobel T.M.
dc.contributor.author Pearson, Sallie Anne
dc.contributor.author Schaffer, Andrea L.
dc.contributor.author Zoéga, Helga
dc.date.accessioned 2022-02-18T01:01:49Z
dc.date.available 2022-02-18T01:01:49Z
dc.date.issued 2021-08-17
dc.identifier.citation Gillies , M B , Burgner , D P , Ivancic , L , Nassar , N , Miller , J E , Sullivan , S G , Todd , I T M , Pearson , S A , Schaffer , A L & Zoéga , H 2021 , ' Changes in antibiotic prescribing following COVID-19 restrictions : Lessons for post-pandemic antibiotic stewardship ' , British Journal of Clinical Pharmacology . https://doi.org/10.1111/bcp.15000
dc.identifier.issn 0306-5251
dc.identifier.other PURE: 43012744
dc.identifier.other PURE UUID: dd3fb0b8-7feb-4abf-88ea-d542ce464e57
dc.identifier.other Scopus: 85112681704
dc.identifier.other WOSLite: 000686520900001
dc.identifier.other unpaywall: 10.1111/bcp.15000
dc.identifier.uri https://hdl.handle.net/20.500.11815/2901
dc.description We thank the Australian Government Services Australia for providing the data and Melisa Litchfield for assisting with data access and ethics approval. This work was supported by the National Health and Medical Research Council (NHMRC) Centre of Research Excellence in Medicines Intelligence [grant number 1196900]. Dr Zoega is supported by a UNSW Scientia Fellowship. Dr Schaffer is supported by an NHMRC Early Career Fellowship [grant number 1158763]. Dr Burgner is supported by an NHMRC Investigator Grant [grant number 1175744]. Dr Nassar was supported by the Financial Markets Foundation for Children and NHMRC Investigator Grant [grant number APP1197940]. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. The WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. The funding bodies did not play any role in the study. Publisher Copyright: © 2021 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
dc.description.abstract Aims: Public health responses to reduce SARS-CoV-2 transmission have profoundly affected the epidemiology and management of other infections. We examined the impact of COVID-19 restrictions on antibiotic dispensing in Australia. Methods: We used national claims data to investigate antibiotic dispensing trends from November 2015 to October 2020 and whether changes reflected reductions in primary care consultations. We used interrupted time series analysis to quantify changes in monthly antibiotic dispensing and face-to-face and telehealth GP consultations and examined changes by recipient age, pharmacy State and prescriber specialty. Results: Over the study period, an estimated 19 921 370 people had 125 495 137 antibiotic dispensings, 71% prescribed by GPs. Following COVID-19 restrictions, we observed a sustained 36% (95% CI: 33–40%) reduction in antibiotic dispensings from April 2020. Antibiotics recommended for managing respiratory tract infections showed large reductions (range 51–69%), whereas those recommended for non-respiratory infections were unchanged. Dispensings prescribed by GPs decreased from 63.5 per 1000 population for April–October 2019 to 37.0 per 1000 for April–October 2020. Total GP consultation rates remained stable, but from April 2020, 31% of consultations were telehealth. Conclusion: In a setting with a low COVID-19 incidence, restrictions were associated with a substantial reduction in community dispensings of antibiotics primarily used to treat respiratory infections, coincident with reported reductions in respiratory viral infections. Our findings are informative for post-pandemic antimicrobial stewardship and highlight the potential to reduce inappropriate prescribing by GPs and specialists for respiratory viral infections.
dc.format.extent
dc.language.iso en
dc.relation.ispartofseries British Journal of Clinical Pharmacology; ()
dc.rights info:eu-repo/semantics/openAccess
dc.subject Sýklalyf
dc.subject Ástralía
dc.subject Ástralía
dc.subject COVID-19
dc.subject Faraldsfræði
dc.subject antibiotics
dc.subject Australia
dc.subject COVID-19
dc.subject epidemiology
dc.subject physical distancing
dc.subject Pharmacology
dc.subject Pharmacology (medical)
dc.title Changes in antibiotic prescribing following COVID-19 restrictions : Lessons for post-pandemic antibiotic stewardship
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 34405427
dc.identifier.doi https://doi.org/10.1111/bcp.15000
dc.relation.url http://www.scopus.com/inward/record.url?scp=85112681704&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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