dc.contributor |
Landspitali - The National University Hospital of Iceland |
dc.contributor.author |
Chartier, Lauren C. |
dc.contributor.author |
Fujino, Junko |
dc.contributor.author |
Howarth, Gordon S. |
dc.contributor.author |
Freysdóttir, Jóna |
dc.contributor.author |
Harðardóttir, Ingibjörg |
dc.contributor.author |
Mashtoub, Suzanne |
dc.date.accessioned |
2022-01-26T01:02:28Z |
dc.date.available |
2022-01-26T01:02:28Z |
dc.date.issued |
2021-06 |
dc.identifier.citation |
Chartier , L C , Fujino , J , Howarth , G S , Freysdóttir , J , Harðardóttir , I & Mashtoub , S 2021 , ' Emu Oil and Saireito in combination reduce tumour development and clinical indicators of disease in a mouse model of colitis-associated colorectal cancer ' , Biomedicine and Pharmacotherapy , vol. 138 , 111478 , pp. 111478 . https://doi.org/10.1016/j.biopha.2021.111478 |
dc.identifier.issn |
0753-3322 |
dc.identifier.other |
42826356 |
dc.identifier.other |
f42ec77a-4119-4321-a306-37bb447df0bb |
dc.identifier.other |
85102828302 |
dc.identifier.other |
33756155 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2859 |
dc.description |
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
dc.description.abstract |
BACKGROUND: Emu Oil (EO) previously demonstrated therapeutic potential in a mouse model of colitis-associated CRC (CA-CRC). Saireito, a traditional Japanese medicine, has not been investigated in CA-CRC. AIM: To determine whether EO and Saireito could be therapeutic in an azoxymethane (AOM)/dextran sulphate sodium (DSS) model of CA-CRC. METHODS: Female C57BL/6 mice were assigned to groups (n = 10/group); 1) saline control, 2) saline+Saireito, 3) saline+EO, 4) saline+EO/Saireito, 5) AOM/DSS control, 6) AOM/DSS+Saireito, 7) AOM/DSS+EO and 8) AOM/DSS+EO/Saireito. Mice were intraperitoneally injected with saline or AOM (7.4 mg/kg) on day 0 and underwent three DSS/water cycles (2%w/v DSS for 7 days, 14 days water). Mice were orally-gavaged with either water (80 µL), Saireito (80 µL), EO (80 µL) or EO/Saireito (160 µL; 80 µL EO + 80 µL Saireito) thrice weekly. Daily bodyweight and disease activity index (DAI) were recorded and colonoscopies performed on days 20, 41 and 62. Mice were euthanized on day 63. p < 0.05 was considered statistically significant. RESULTS: AOM/DSS induced significant bodyweight loss throughout the trial (max -36%), which was attenuated by Saireito (max +7%), EO (max +5%) and EO/Saireito (max +14%; p < 0.05). AOM/DSS increased DAI compared to saline controls (p < 0.05), which was reduced by Saireito, EO and EO/Saireito (p < 0.05). All treatments reduced colonoscopically-assessed colitis severity (days 20 and 41; p < 0.05). EO/Saireito further decreased colitis severity compared to Saireito and EO alone (day 20; p < 0.05). Finally, EO and EO/Saireito resulted in fewer colonic tumours compared to AOM/DSS controls (p < 0.05). CONCLUSION: Combined EO and Saireito reduced disease and tumour development in AOM/DSS mice, suggesting therapeutic potential in CA-CRC. |
dc.format.extent |
8135682 |
dc.format.extent |
111478 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Biomedicine and Pharmacotherapy; 138() |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Lyfjafræði |
dc.subject |
Ristilkrabbamein |
dc.subject |
Emu olía |
dc.subject |
Saireito |
dc.subject |
Emu olía |
dc.subject |
Saireito |
dc.subject |
Sáraristilbólga |
dc.subject |
Colorectal cancer |
dc.subject |
Emu Oil |
dc.subject |
Kampo medicine |
dc.subject |
Mouse model |
dc.subject |
Nutraceuticals |
dc.subject |
Ulcerative colitis |
dc.subject |
Mice, Inbred C57BL |
dc.subject |
Colorectal Neoplasms/chemically induced |
dc.subject |
Animals |
dc.subject |
Drugs, Chinese Herbal/administration & dosage |
dc.subject |
Oils/administration & dosage |
dc.subject |
Anti-Inflammatory Agents/administration & dosage |
dc.subject |
Female |
dc.subject |
Mice |
dc.subject |
Drug Therapy, Combination |
dc.subject |
Colitis-Associated Neoplasms/chemically induced |
dc.subject |
Dextran Sulfate/toxicity |
dc.subject |
Disease Models, Animal |
dc.subject |
Pharmacology |
dc.title |
Emu Oil and Saireito in combination reduce tumour development and clinical indicators of disease in a mouse model of colitis-associated colorectal cancer |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1016/j.biopha.2021.111478 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85102828302&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.department |
Clinical Laboratory Services, Diagnostics and Blood Bank |