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Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population

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dc.contributor.author Aanstoot, H. J.
dc.contributor.author Sigurdsson, Engilbert
dc.contributor.author Jaffe, M.
dc.contributor.author Shi, Y.
dc.contributor.author Christgau, S.
dc.contributor.author Grobbee, D.
dc.contributor.author Bruining, G. J.
dc.contributor.author Molenaar, J. L.
dc.contributor.author Hofman, A.
dc.contributor.author Baekkeskov, S.
dc.date.accessioned 2022-01-26T01:02:05Z
dc.date.available 2022-01-26T01:02:05Z
dc.date.issued 1994-09
dc.identifier.citation Aanstoot , H J , Sigurdsson , E , Jaffe , M , Shi , Y , Christgau , S , Grobbee , D , Bruining , G J , Molenaar , J L , Hofman , A & Baekkeskov , S 1994 , ' Value of antibodies to GAD 65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population ' , Diabetologia , vol. 37 , no. 9 , pp. 917-924 . https://doi.org/10.1007/BF00400948
dc.identifier.issn 0012-186X
dc.identifier.other PURE: 40592459
dc.identifier.other PURE UUID: 58829ee4-7e39-4916-98f1-ed08e22323e5
dc.identifier.other Scopus: 0028169720
dc.identifier.uri https://hdl.handle.net/20.500.11815/2856
dc.description This study was supported by the Lee Iacocca grant of the March of Dimes Foundation, by the foundation Nordisk Insulinlaboratorium, and by fellowships from the Icelandic Research Academy (ES), the Danish Research Academy (SC), the Dutch Research Academy/Ter Meulen Foundation (HJA) and the Sophia Foundation (HJA).
dc.description.abstract The value of a test for islet cell cytoplasmic antibodies together with a test for GAD65 antibodies to predict the subsequent development of diabetes over a period of 11.5 years was assessed in an open childhood population comprising 2,805 individuals. A single serum sample was obtained from each individual between 1975 and 1977 and screened for islet cell cytoplasmic antibodies for which eight individuals were positive (0.29%). During the average follow-up period of 11.5 years, four of eight islet cell antibody positive and three islet cell antibody negative individuals developed clinical diabetes. Sera from all individuals, who were islet cell antibody positive and/ or developed diabetes (total of 11) and from 100 randomly selected control subjects were analysed for GAD65 antibodies. Six of eight islet cell antibody positive individuals were GAD65 antibody positive including all four who subsequently developed IDDM. Furthermore, one of the three islet cell antibody negative individuals who developed IDDM was GAD65 antibody positive both in 1976 and in 1989. Thus, a positive test for GAD65 antibodies alone correctly predicted diabetes in five of seven children, who developed the disease. Only one of the children, who developed diabetes was positive for insulin autoantibodies and this individual was also positive for islet cell cytoplasmic antibodies and GAD65 antibodies. One of the 100 control subjects was positive for GAD65 antibodies (1%). The results suggest that a single GAD65 antibody test may have a higher sensitivity for predicting IDDM than a test for islet cell cytoplasmic antibodies, but that a combined positive test for both antibodies increases the specificity for predicting IDDM over a period of 11.5 years.
dc.format.extent 8
dc.format.extent 917-924
dc.language.iso en
dc.relation.ispartofseries Diabetologia; 37(9)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Sykursýki
dc.subject Börn
dc.subject GAD antibodies
dc.subject IDDM in childhood
dc.subject islet cell cytoplasmic antibodies
dc.subject predictive value
dc.subject Internal Medicine
dc.subject Endocrinology, Diabetes and Metabolism
dc.title Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 7806022
dc.identifier.doi https://doi.org/10.1007/BF00400948
dc.relation.url http://www.scopus.com/inward/record.url?scp=0028169720&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Mental Health Services


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