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Combined effects of external moments and muscle activations on acl loading during numerical simulations of a female model in opensim

Combined effects of external moments and muscle activations on acl loading during numerical simulations of a female model in opensim


Title: Combined effects of external moments and muscle activations on acl loading during numerical simulations of a female model in opensim
Author: Daliet, Oliver J.
Briem, Kristín
Brynjólfsson, Sigurður
Sigurðsson, Haraldur Björn
Date: 2021-12-16
Language: English
Scope:
Department: Faculty of Medicine
Faculty of Industrial Engineering, Mechanical Engineering and Computer Science
Series: Applied Sciences (Switzerland); 11(24)
ISSN: 2076-3417
DOI: https://doi.org/10.3390/app112411971
Subject: Hné; Liðamót; Hreyfifærni; Áverkar; Biomechanics; Computer simulations; In silico; Injury mechanism; Knee joint; Motion analysis; Materials Science (all); Instrumentation; Engineering (all); Process Chemistry and Technology; Computer Science Applications; Fluid Flow and Transfer Processes
URI: https://hdl.handle.net/20.500.11815/2854

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Citation:

Daliet , O J , Briem , K , Brynjólfsson , S & Sigurðsson , H B 2021 , ' Combined effects of external moments and muscle activations on acl loading during numerical simulations of a female model in opensim ' , Applied Sciences (Switzerland) , vol. 11 , no. 24 , 11971 . https://doi.org/10.3390/app112411971

Abstract:

Background: Anterior cruciate ligament (ACL) injuries have been studied using a variety of methods and tools. However, each is hindered by specific limitations with respect to its application. Aim: To assess the combined effects of external moments and muscle activations on ACL loading using serial, forward dynamics (FD) simulations of single leg, hyperextension landings in OpenSim. Methods: The FD tool of OpenSim was iteratively run using different combinations of knee-spanning muscle activation levels, internal rotation and valgus knee moment magnitudes. A regression was conducted on the data in order to predict ACL loading under different conditions. Results: A purely abduction moment leads to greater mean ACL loading than a purely internal rotation moment or any combination of the two. Additionally, the generalized boosted regression model using both external moments and certain knee muscles identified the internal rotation moment as the most important variable in predicting the ACL load (R2 = 0.9; p < 0.0001). Conclusion: This study demonstrated a novel and practical application of an OpenSim musculoskeletal model that supports the ACL injury mechanism of landing with low knee flexion angles, high muscle forces of the Quadriceps muscles and an external knee valgus moment, though further investigation is needed.

Description:

Funding text Funding: This research was funded by a U.S. Fulbright Fellowship grant (recipient; O.D.). The remaining authors were funded through a grant from The Icelandic Centre for Research (accessed on 13 December 2021), grant numbers 120410021, 903271305, 1203250031, and 185359051. No funding source had any input in the design of the study, writing of the manuscript, nor the decision to submit the manuscript for publication. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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