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Group B streptococcal infections in infants in Iceland : Clinical and microbiological factors

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dc.contributor.author Bæringsdóttir, Birta
dc.contributor.author Erlendsdóttir, Helga
dc.contributor.author Björnsdóttir, Erla Soffía
dc.contributor.author Martins, Elisabete R.
dc.contributor.author Ramirez, Mário
dc.contributor.author Haraldsson, Ásgeir
dc.contributor.author Þórkelsson, Þórður
dc.date.accessioned 2021-12-18T01:02:08Z
dc.date.available 2021-12-18T01:02:08Z
dc.date.issued 2021-09-23
dc.identifier.citation Bæringsdóttir , B , Erlendsdóttir , H , Björnsdóttir , E S , Martins , E R , Ramirez , M , Haraldsson , Á & Þórkelsson , Þ 2021 , ' Group B streptococcal infections in infants in Iceland : Clinical and microbiological factors ' , Journal of Medical Microbiology , vol. 70 , no. 9 , 001426 . https://doi.org/10.1099/jmm.0.001426
dc.identifier.issn 0022-2615
dc.identifier.other PURE: 41590940
dc.identifier.other PURE UUID: f42be79a-fc98-4b74-9b84-830dc29b2c2c
dc.identifier.other Scopus: 85117432152
dc.identifier.uri https://hdl.handle.net/20.500.11815/2759
dc.description Funding information: Landspitali-University Hospital of Iceland, Research Fund, 2019. Publisher Copyright: © 2021 The Authors
dc.description.abstract Introduction. Group B streptococcus (GBS) is a leading cause of invasive neonatal infections. These have been divided into early-onset disease (EOD; <7 days) and late-onset disease (LOD; 7–89 days), with different GBS clonal complexes (CCs) associated with different disease presentations. Hypothesis. Different GBS CCs are associated with timing of infection (EOD or LOD) and clinical presentation (sepsis, meningitis or pneumonia). Aim. To study infant GBS infections in Iceland from 1975 to 2019. Are specific GBS CCs related to disease presentation? Is CC17 overrepresented in infant GBS infections in Iceland? Methodology. All culture-confirmed invasive GBS infections in infants (<90 days) in Iceland from 1975 to 2019 were included. Clinical information was gathered from medical records. Results. A total of 127 invasive GBS infections in infants were diagnosed, but 105 infants were included in the study. Of these, 56 had EOD and 49 had LOD. The incidence of GBS infections declined from 2000 onwards but increased again at the end of the study period. Furthermore, there was a significant increase in LOD over the study period (P=0.0001). The most common presenting symptoms were respiratory difficulties and fever and the most common presentation was sepsis alone. Approximately one-third of the cases were caused by GBS CC17 of serotype III with surface protein RIB and pili PI-1+ PI-2b or PI-2b. CC17 was significantly associated with LOD (P<0.001). Conclusion. CC17 is a major cause of GBS infection in infants in Iceland. This clone is associated with LOD, which has been increasing in incidence. Because intrapartum antibiotic prophylaxis only prevents EOD, it is important to continue the development of a GBS vaccine in order to prevent LOD infections.
dc.language.iso en
dc.relation.ispartofseries Journal of Medical Microbiology; 70(9)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Ungbörn
dc.subject Heilahimnubólga
dc.subject Nýburar
dc.subject Blóðeitrun
dc.subject Barnalæknisfræði
dc.subject Náttúrufræðingar
dc.subject GBS infections
dc.subject Infants
dc.subject Meningitis
dc.subject Neonates
dc.subject Sepsis
dc.subject Microbiology
dc.subject Microbiology (medical)
dc.title Group B streptococcal infections in infants in Iceland : Clinical and microbiological factors
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 34554080
dc.identifier.doi https://doi.org/10.1099/jmm.0.001426
dc.relation.url http://www.scopus.com/inward/record.url?scp=85117432152&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Women's and Childrens's Services
dc.contributor.department Clinical Laboratory Services, Diagnostics and Blood Bank

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