IRIS: Síðast bætt við

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    Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor 
    Dowsett, Joseph; Ferkingstad, Egil; Rasmussen, Line Jee Hartmann; Thørner, Lise Wegner; Magnússon, Magnús Karl; Sugden, Karen; Þorleifsson, Guðmar; Frigge, Mike; Burgdorf, Kristoffer Sølvsten; Ostrowski, Sisse Rye; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Hansen, Thomas Folkmann; Banasik, Karina; Brunak, Søren; Tragante, Vinicius; Lund, Sigrún Helga; Stefánsdóttir, Lilja; Gunnarson, Bjarni; Poulton, Richie; Arseneault, Louise; Caspi, Avshalom; Moffitt, Terrie E.; Gudbjartsson, Daníel Fannar; Eugen-Olsen, Jesper; Stefánsson, Hreinn; Stefánsson, Kári; Ullum, Henrik (2021-06-02)
    Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed ...
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    Áhrif lyfsins fampridíns á skerta göngugetu sjúklinga með MS (Multiple Sclerosis) 
    Guðjónsdóttir, Björg; Hjaltason, Haukur; Andrésdóttir, Guðbjörg Þóra (2021-04)
    INTRODUCTION: Fampridine is a drug for people with Multiple Sclerosis (MS). It is a broad-spectrum voltage-dependent potassium channel blocker that enhances synaptic transmission. The drug has been shown to be able to enhance conduction in demyelinated ...
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    Relationship between scoliosis, windswept hips and contractures with pain and asymmetries in sitting and supine in 2450 children with cerebral palsy 
    Casey, Jackie; Ágústsson, Atli; Rosenblad, Andreas; Rodby-Bousquet, Elisabet (2021-09-06)
    Purpose: This cross-sectional study of 2450 children with cerebral palsy aimed to analyse the prevalence and association of scoliosis, windswept hips, hip and knee contractures. Methods: Logistic regression was used to estimate associations with pain, ...
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    Clinical management of patients with drug-induced liver injury (DILI) 
    Björnsson, Einar Stefán (2021-06-28)
    Drug-induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. There is currently no biomarker that is helpful in diagnosis which relies on clinical ...
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    Predicting the probability of death using proteomics 
    Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...
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    Forysta sem samstarfsverkefni: áhersla skólastjóra á valddreifingu og samstarf 
    Hansen, Börkur; Lárusdóttir, Steinunn Helga (2019-12-15)
    Í nútímakenningum um skólastjórnun er kastljósinu jafnan beint að sýn skólastjóra á hlutverk sitt og tengsl við samstarfsfólk. Þá er átt við að skólastjórar og kennarar starfi saman að því að þróa skólastarf og kennsluhætti. Markmiðið með slíkum ...
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    Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity 
    Novotny, Ella N.; White, Samuel J.; Wilson, A. Douglas; Stefánsdóttir, Sara Björk; Tijhaar, Edwin; Jónsdóttir, Sigríður; Frey, Rebekka; Reiche, Dania; Rose, Horst; Rhyner, Claudio; Schüpbach-Regula, Gertraud; Þorsteinsdóttir, Sigurbjörg; Alcocer, Marcos; Marti, Eliane (2021-04)
    Background: Allergy to bites of blood-sucking insects, including biting midges, can affect both human and veterinary patients. Horses are often suffering from an IgE-mediated allergic dermatitis caused by bites of midges (Culicoides spp). With the aim ...
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    Þættir sem hafa áhrif á ákvörðun lækna um lyfjameðferð : Rannsókn í heilsugæslu á Íslandi 
    Ivarsdottir, Yrsa; Jónsson, Jón Steinar; Linnet, Kristjan; Blöndal, Anna Bryndís (2021-11-01)
    INTRODUCTION: This study aimed to analyse several factors that influence the decision-making of primary care physicians in Iceland in their choice of drug therapy for their patients. Also, to find which factors can act as a hindrance in making the best ...
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    Hvernig skynjum við sársauka? - Nóbelsverðlaun í lífeðlis- og læknisfræði 2021 
    Ólafsson, Elías (2021-11)
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    Replacement of traditional prothrombin time monitoring with the new Fiix prothrombin time increases the efficacy of warfarin without increasing bleeding. A review article 
    Önundarson, Páll Torfi; Palsson, Ragnar; Witt, Daniel M.; Gudmundsdottir, Brynja R. (2021-10-15)
    The antithrombotic effect of vitamin K antagonists (VKA) depends on controlled lowering of the activity of factors (F) II and X whereas reductions in FVII and FIX play little role. PT-INR based monitoring, however, is highly influenced by FVII, which ...
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    Ábendingar og árangur ósæðarlokuísetningar með þræðingartækni (TAVI) á Íslandi 
    Lárusdóttir, Katrín Júniána; Guðmundsson, Hjalti J.; Johnsen, Árni; Sigurðsson, Martin Ingi; Guðbjartsson, Tómas; Guomundsdóttir, Ingibjörg Jóna (2021-03)
    INNGANGUR Ósæðarlokuþrengsl eru algengasti lokusjúkdómurinn á Vesturlöndum. Hefðbundin meðferð við alvarlegum þrengslum hefur verið opin ósæðarlokuskipti en síðastliðin ár hefur ósæðarlokuísetning með þræðingartækni (TAVI) rutt sér til rúms hér á landi ...
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    Þróun lyfjaávísana á ópíóíðalyf í heilsugæslu á árabilinu 2008 til 2017 
    Oladottir, Sigridur; Jónsson, Jón Steinar; Tómasdóttir, Margrét Ólafía; Hrafnkelsson, Hannes; Sigurdsson, Emil Larus (2021-10)
    INTRODUCTION: In recent decades there has been a notable increase in the prescription of opioids in western countries. With this rise in use of opioids the risk of side effects, opioid abuse and deaths linked to opioids have become more apparent. The ...
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    Sequence variants in malignant hyperthermia genes in Iceland : classification and actionable findings in a population database 
    Fridriksdottir, Run; Jónsson, Arnar Jan; Jensson, Brynjar O.; Sverrisson, Kristinn O.; Arnadottir, Gudny A.; Skarphéðinsdóttir, Sigurbjorg J.; Katrinardottir, Hildigunnur; Snaebjornsdottir, Steinunn; Jonsson, Hakon; Eiriksson, Ogmundur; Óskarsson, Guðjón Reykdal; Oddsson, Asmundur; Jonasdottir, Adalbjorg; Jonasdottir, Aslaug; Sigurdsson, Gisli H.; Indriðason, Einar Páll; Sigurðsson, Stefán B.; Bjornsdottir, Gyda; Saemundsdottir, Jona; Magnusson, Olafur T.; Björnsson, Hans Tómas; Thorsteinsdottir, Unnur; Sigurdsson, Theodor S.; Sulem, Patrick; Sigurðsson, Martin Ingi; Stefansson, Kari (2021-08-31)
    Malignant hyperthermia (MH) susceptibility is a rare life-threatening disorder that occurs upon exposure to a triggering agent. MH is commonly due to protein-altering variants in RYR1 and CACNA1S. The American College of Medical Genetics and Genomics ...
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    Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study 
    Westerlind, Helga; Palmqvist, Ida; Saevarsdottir, Saedis; Alfredsson, Lars; Klareskog, Lars; Di Giuseppe, Daniela (2021-08-07)
    BACKGROUND: Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, ...
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    Einstaklingar sem nota vímuefni í æð á Íslandi : Bráðakomur og innlagnir á Landspítala og dánartíðni 
    Rafnar, Bjarni Össurarson; Haraldsson, Magnús; Bjarnadóttir, Guðrún Dóra (2021)
    INTRODUCTION: Drug abuse is a significant contributor to premature disease and mortality. Drug users are less likely to attend traditional Primary Health Care and more likely to present to Emergency Departments with their problems. Drug users often ...
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    Does antipsychotic use mediate the effect of psychiatric disorders on COVID-19? – Authors' reply 
    Yang, Huazhen; Chen, Wenwen; Fang, Fang; Valdimarsdóttir, Unnur A.; Song, Huan (2021-02)
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    Dementia risk in the general population : large-scale external validation of prediction models in the AGES-Reykjavik study 
    Vonk, Jet M.J.; Greving, Jacoba P.; Gudnason, Vilmundur; Launer, Lenore J.; Geerlings, Mirjam I. (2021-07-25)
    We aimed to evaluate the external performance of prediction models for all-cause dementia or AD in the general population, which can aid selection of high-risk individuals for clinical trials and prevention. We identified 17 out of 36 eligible published ...
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    Illness severity and risk of mental morbidities among patients recovering from COVID-19 : A cross-sectional study in the Icelandic population 
    Saevarsdóttir, Karen Sól; Hilmarsdóttir, Hildur Ýr; Magnúsdóttir, Ingibjörg; Hauksdóttir, Arna; Thordardottir, Edda Bjork; Gudjónsdóttir, Ásdís Braga; Tomasson, Gunnar; Rúnarsdóttir, Harpa; Jónsdóttir, Harpa Lind; Gudmundsdóttir, Berglind; Pétursdóttir, Gudrún; Petersen, Pétur Henry; Kristinsson, Sigurdur Yngvi; Love, Thorvardur Jon; Hansdóttir, Sif; Hardardóttir, Hrönn; Gudmundsson, Gunnar; Eythorsson, Elias; Gudmundsdóttir, Dóra Gudrún; Sigbjörnsdóttir, Hildur; Haraldsdóttir, Sigrídur; Möller, Alma Dagbjört; Palsson, Runolfur; Jakobsdóttir, Jóhanna; Aspelund, Thor; Valdimarsdottir, Unnur (2021-07-23)
    Objective To test if patients recovering from COVID-19 are at increased risk of mental morbidities and to what extent such risk is exacerbated by illness severity. Design Population-based cross-sectional study. Setting Iceland. Participants A total of ...
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    Clinical indications of premenstrual disorders and subsequent risk of injury : a population-based cohort study in Sweden 
    Yang, Qian; Sjölander, Arvid; Li, Yuchen; Viktorin, Alexander; Bertone-Johnson, Elizabeth R.; Ye, Weimin; Fang, Fang; Valdimarsdóttir, Unnur A.; Lu, Donghao (2021-05-26)
    Background: Premenstrual disorders, including premenstrual syndrome and premenstrual dysphoric disorder, are suggested to be correlated with suicidal behavior and accidents in cross-sectional and retrospective studies. However, prospective data are ...
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    Cardiovascular-related deaths at the beginning of the COVID-19 outbreak : A prospective analysis based on the UK Biobank 
    Wang, Junren; Zhu, Jianwei; Yang, Huazhen; Hu, Yao; Sun, Yajing; Ying, Zhiye; Qu, Yuanyuan; Valdimarsdottir, Unnur; Fang, Fang; Song, Huan (2021-06-04)
    Objective To assess the impact of the COVID-19 outbreak on cardiovascular disease (CVD) related mortality and hospitalisation. Design Community-based prospective cohort study. Setting The UK Biobank. Participants 421 372 UK Biobank participants who ...