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Browsing Iris by Title

Browsing Iris by Title

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  • Hansen, Karólína; Björnsson, Hjalti Már; Gunnbjörnsdóttir, María I. (2021-10)
    Background Diagnosing anaphylaxis is often straightforward but can be challenging if the presentation is atypical. In patients with atypical symptoms suspected to be due to an acute allergic reaction, s-tryptase can give additional diagnostic information. ...
  • Clemons, Janine H.; Payne, Deborah; Garrett, Nick; McAra-Couper, Judith; Farry, Annabel; Swift, Emma Marie; Stoll, Kathrin (2022-12-01)
    Objective: To determine whether participant characteristics and/or birth preferences of future mothers are associated with a fear of birth. Design: A cross-sectional survey was used to determine if fear of birth could be profiled in specific participant ...
  • Sammar, Marei; Drobnjak, Tijana; Mandala, Maurizio; Gizurarson, Sveinbjörn; Huppertz, Berthold; Meiri, Hamutal (2019-07-01)
    Galectins regulate cell growth, proliferation, differentiation, apoptosis, signal transduction, mRNA splicing, and interactions with the extracellular matrix. Here we focus on the galectins in the reproductive system, particularly on a group of six ...
  • Hjaltadóttir, Katrín; Haraldsdóttir, Kristín Huld; Möller, Páll Helgi (2020-10)
    Ágrip Gallsteinar og fylgikvillar þeirra eru með algengustu innlagnarástæðum á skurðdeildir. Meðalalgengi gallsteina er um 20% og virðist sem innlögnum og aðgerðum vegna þeirra fari fjölgandi. Gallsteinar myndast yfirleitt í gallblöðrunni en geta einnig ...
  • Brosowski, Tim; Ólason, Daníel Þór; Turowski, Tobias; Hayer, Tobias (2020-01-21)
    Bivariate associations of problem gambling with participation in particular game types often decrease when adjusting for demographics or consumption behavior (e.g., number of game types played). A summary of 14 peer-reviewed studies showed inconsistencies ...
  • Atladóttir, Erla Þórdís; Óskarsson, Kristján; Möller, Páll Helgi (2022-01-04)
    Garnasmokkun á botnlanga er sjaldgæft ástand og erfitt að greina. Við segjum frá garnasmokkun á botnlanga hjá 7 ára gömlum strák með sögu um kviðverki. Intussusception of appendix is a rare condition and difficult to diagnose. We report a case of ...
  • Pearson, Sallie Anne; Pratt, Nicole; Costa, Juliana de Oliveira; Zoéga, Helga; Laba, Tracey Lea; Etherton-Beer, Christopher; Sanfilippo, Frank M.; Morgan, Alice; Ellett, Lisa Kalisch; Bruno, Claudia; Kelty, Erin; Ijzerman, Maarten; Preen, David B.; Vajdic, Claire M.; Henry, David (2021-12-18)
    Australia spends more than $20 billion annually on medicines, delivering significant health benefits for the population. However, inappropriate prescribing and medicine use also result in harm to individuals and populations, and waste of precious health ...
  • Oskarsson, Gudjon R.; Magnússon, Magnús Karl; Oddson, Ásmundur; Jensson, Brynjar O; Friðriksdóttir, Rún; Arnadottir, Gudny A; Katrinardottir, Hildigunnur; Rögnvaldsson, Sölvi; Halldórsson, Gísli Hreinn; Sveinbjörnsson, Gardar; Ivarsdottir, Erna V.; Stefánsdóttir, Lilja; Ferkingstad, Egil; Norland, Kristjan; Tragante, Vinicius; Sæmundsdóttir, Jóna; Jónasdóttir, Áslaug; Jonasdottir, Adalbjorg; Sigurjonsdottir, Svanhvit; Petursdottir, Karen O.; Davidsson, Olafur B; Rafnar, Thorunn; Hólm, Hilma; Ólafsson, Ísleifur; Önundarson, Páll Torfi; Viðarsson, Brynjar; Sigurdardottir, Olof G.; Másson, Gísli; Gudbjartsson, Daniel Fannar; Jónsdóttir, Ingileif; Norddahl, Gudmundur L.; Þorsteinsdóttir, Unnur; Sulem, Patrick; Stefánsson, Kári (2022-06-01)
    The characteristic lobulated nuclear morphology of granulocytes is partially determined by composition of nuclear envelope proteins. Abnormal nuclear morphology is primarily observed as an increased number of hypolobulated immature neutrophils, called ...
  • Early Growth Genetics Consortium; Steingrímsdóttir, Þóra (2023-04-03)
    The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 ...
  • DBDS Genomic Consortium (2021-02-13)
    Aims: The aim of this study was to use human genetics to investigate the pathogenesis of sick sinus syndrome (SSS) and the role of risk factors in its development. Methods and results: We performed a genome-wide association study of 6469 SSS cases and ...
  • Lifelines Cohort Study (2022-09)
    Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain ...
  • Hahn, Julie; Fu, Yi Ping; Brown, Michael R.; Bis, Joshua C.; de Vries, Paul S.; Feitosa, Mary F.; Yanek, Lisa R.; Weiss, Stefan; Giulianini, Franco; Smith, Albert Vernon; Guo, Xiuqing; Bartz, Traci M.; Becker, Diane M.; Becker, Lewis C.; Boerwinkle, Eric; Brody, Jennifer A.; Chen, Yii Der Ida; Franco, Oscar H.; Grove, Megan; Harris, Tamara B.; Hofman, Albert; Hwang, Shih Jen; Kral, Brian G.; Launer, Lenore J.; Markus, Marcello R.P.; Rice, Kenneth M.; Rich, Stephen S.; Ridker, Paul M.; Rivadeneira, Fernando; Rotter, Jerome I.; Sotoodehnia, Nona; Taylor, Kent D.; Uitterlinden, André G.; Völker, Uwe; Völzke, Henry; Yao, Jie; Chasman, Daniel I.; Dörr, Marcus; Gudnason, Vilmundur; Mathias, Rasika A.; Post, Wendy; Psaty, Bruce M.; Dehghan, Abbas; O’Donnell, Christopher J.; Morrison, Alanna C. (2020-11)
    Background Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. ...
  • Liu, Xiaoyan; Swen, Jesse J.; Diekstra, Meta H.M.; Boven, Epie; Castellano, Daniel; Gelderblom, Hans; Mathijssen, Ron H.J.; Vermeulen, Sita H.; Oosterwijk, Egbert; Junker, Kerstin; Roessler, Max; Alexiusdottir, Kristin; Sverrisdóttir, Ásgerður; Radu, Marius T.; Ambert, Valentin; Eisen, Tim; Warren, Anne; Rodríguez-Antona, Cristina; García-Donas, Jesus; Böhringer, Stefan; Koudijs, Karel K.M.; Kiemeney, Lambertus A.L.M.; Rini, Brian I.; Guchelaar, Henk-Jan (2018-05-15)
    Purpose: The survival of patients with clear cell metastatic renal cell carcinoma (cc-mRCC) has improved substantially since the introduction of tyrosine kinase inhibitors (TKI). With the fact that TKIs interact with immune responses, we investigated ...
  • Van Zuydam, Natalie R.; Ladenvall, Claes; Voight, Benjamin F.; Strawbridge, Rona J.; Fernandez-Tajes, Juan; Rayner, N. William; Robertson, Neil R.; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E.; Nelson, Christopher P.; Kwee, Lydia Coulter; Esko, Tõnu; Mihailov, Evelin; Mägi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; Song, Ci; Hartiala, Jaana A.; Pedersen, Nancy L.; Perola, Markus; Gieger, Christian; Peters, Annette; Qu, Liming; Willems, Sara M.; Doney, Alex S.F.; Morris, Andrew D.; Zheng, Yan; Sesti, Giorgio; Hu, Frank B.; Qi, Lu; Laakso, Markku; Thorsteinsdottir, Unnur; Grallert, Harald; Van Duijn, Cornelia; Reilly, Muredach P.; Ingelsson, Erik; Deloukas, Panos; Kathiresan, Sek; Metspalu, Andres; Shah, Svati H.; Sinisalo, Juha; Salomaa, Veikko; Hamsten, Anders; Samani, Nilesh J.; März, Winfried; Hazen, Stanley L. (2020-12-01)
    Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of ...
  • FINNPEC Consortium; GOPEC Consortium; Thorsteinsdottir, Unnur (2020-12)
    Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal ...
  • Nicoletti, Paola; Devarbhavi, Harshad; Goel, Ashish; Venkatesan, Radha; Eapen, Chundamannil E.; Grove, Jane I.; Zafer, Samreen; Björnsson, Einar Stefán; Lucena, M. Isabel; Andrade, Raul J.; Pirmohamed, Munir; Wadelius, Mia; Larrey, Dominique; Maitland-van der Zee, Anke Hilse; Ibanez, Luisa; Watkins, Paul B.; Daly, Ann K.; Aithal, Guruprasad P. (2021-04)
    Drug-induced liver injury (DILI) is a complication of treatment with antituberculosis (TB) drugs, especially in isoniazid (INH)-containing regimens. To investigate genetic risk factors, we performed a genomewide association study (GWAS) involving anti-TB ...
  • Mattingsdal, Morten; Ebenesersdóttir, Sigríður Sunna; Moore, Kristjan Helgi Swerford; Andreassen, Ole A.; Hansen, Thomas Folkmann; Werge, Thomas M.; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Helgason, Agnar Sturla; Stefánsson, Kári; Hovig, Eivind (2021-11)
    The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based ...
  • Norén-Nyström, Ulrika; Andersen, Mette K; Barbany, Gisela; Dirse, Vaidas; Eilert-Olsen, Martine; Engvall, Marie; Harila-Saari, Arja; Heyman, Mats; Hovland, Randi; Häikiö, Satu; Jónsson, Jón Jóhannes; Karhu, Ritva; Kjeldsen, Eigil; Norberg, Anna; Preiss, Birgitte S; Pulkkinen, Kati; Quist-Paulsen, Petter; Räsänen, Hannele; Schmiegelow, Kjeld; Seitsonen, Anne; Sjögren, Helene; Tammur, Pille; Johansson, Bertil (2023-05)
  • Eiríksson, Finnur Freyr; Helgadottir, Anna; Thorleifsson, Gudmar; Alexandersson, Kristjan F.; Tragante, Vinicius; Þorsteinsdóttir, Margrét; Grétarsdóttir, Solveig; Björnsson, Eyþór; Magnússon, Ólafur; Sveinbjornsson, Gardar; Jónsdóttir, Ingileif; Steinthorsdottir, Valgerdur; Ferkingstad, Egil; Jensson, Brynjar Ö; Stefansson, Hreinn; Ólafsson, Ísleifur; Christensen, Alex H; Torp-Pedersen, Christian; Køber, Lars; Pedersen, Ole B; Erikstrup, Christian; Sorensen, Erik; Brunak, Søren; Banasik, Karina; Hansen, Thomas Folkmann; Nyegaard, Mette; Eyjolfssson, Gudmundur I; Sigurdardottir, Olof; Thorarinsson, Bjorn L; Matthiasson, Stefan E.; Steingrimsdottir, Thora; Bjornsson, Einar S; Danielsen, Ragnar; Asselbergs, Folkert W; Arnar, Davíð Ottó; Ullum, Henrik; Bundgaard, Henning; sulem, patrick; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Holm, Hilma; Gudbjartsson, Daniel F; Stefansson, Kari (2020)
    Aims To explore whether variability in dietary cholesterol and phytosterol absorption impacts the risk of coronary artery disease (CAD) using as instruments sequence variants in the ABCG5/8 genes, key regulators of intestinal absorption of dietary ...
  • Mishra, Aniket; Duplaà, Cecile; Vojinovic, Dina; Suzuki, Hideaki; Sargurupremraj, Muralidharan; Zilhão, Nuno R.; Li, Shuo; Bartz, Traci M.; Jian, Xueqiu; Zhao, Wei; Hofer, Edith; Wittfeld, Katharina; Harris, Sarah E.; Van Der Auwera-Palitschka, Sandra; Luciano, Michelle; Bis, Joshua C.; Adams, Hieab H.H.; Satizabal, Claudia L.; Gottesman, Rebecca F.; Gampawar, Piyush G.; Bülow, Robin; Weiss, Stefan; Yu, Miao; Bastin, Mark E.; Lopez, Oscar L.; Vernooij, Meike W.; Beiser, Alexa S.; Völker, Uwe; Kacprowski, Tim; Soumare, Aicha; Smith, Jennifer A.; Knopman, David S.; Morris, Zoe; Zhu, Yicheng; Rotter, Jerome I.; Dufouil, Carole; Valdes Hernández, Maria; Muñoz Maniega, Susana; Lathrop, Mark; Boerwinkle, Erik; Schmidt, Reinhold; Ihara, Masafumi; Mazoyer, Bernard; Yang, Qiong; Joutel, Anne; Tournier-Lasserve, Elizabeth; Launer, Lenore J.; Deary, Ian J.; Mosley, Thomas H.; Gudnason, Vilmundur (2022-06-01)
    Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited. We report a genome-wide ...