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A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Grönwall, Caroline; Liljefors, Lisa; Bang, Holger; Hensvold, Aase H.; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Joshua, Vijay; Svärd, Anna; Stålesen, Ragnhild; Titcombe, Philip J.; Steen, Johanna; Piccoli, Luca; Sherina, Natalia; Clavel, Cyril; Svenungsson, Elisabet; Gunnarsson, Iva; Sævarsdóttir, Sædís; Kastbom, Alf; Serre, Guy; Alfredsson, Lars; Malmström, Vivianne; Rönnelid, Johan; Catrina, Anca I.; Lundberg, Karin; Klareskog, Lars (2021-05-20)

Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. ...
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study

Westerlind, Helga; Palmqvist, Ida; Saevarsdottir, Saedis; Alfredsson, Lars; Klareskog, Lars; Di Giuseppe, Daniela (2021-08-07)

BACKGROUND: Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, ...
Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis—a spin-off study of the NORD-STAR randomized clinical trial

Stockfelt, Marit; Lundell, Anna Carin; Hetland, Merete Lund; Østergaard, Mikkel; Uhlig, Till; Heiberg, Marte Schrumpf; Haavardsholm, Espen A.; Nurmohamed, Michael T.; Lampa, Jon; Nordström, Dan; Petersen, Kim Hørslev; Guðbjörnsson, Björn; Gröndal, Gerður; Aldridge, Jonathan; Andersson, Kerstin; Blennow, Kaj; Zetterberg, Henrik; van Vollenhoven, Ronald; Rudin, Anna (2021-07-13)

Background: The type I interferon (IFN) gene signature is present in a subgroup of patients with early rheumatoid arthritis (RA). Protein levels of IFNα have not been measured in RA and it is unknown whether they associate with clinical characteristics ...
Short-term, intermediate-term and long-term risks of acute coronary syndrome in cohorts of patients with RA starting biologic DMARDs : results from four Nordic countries

Delcoigne, Benedicte; Ljung, Lotta; Provan, Sella A; Glintborg, Bente; Hetland, Merete Lund; Grøn, Kathrine Lederballe; Peltomaa, Ritva; Relas, Heikki; Turesson, Carl; Guðbjörnsson, Björn; Michelsen, Brigitte; Askling, Johan (2022-03-22)

OBJECTIVES: To compare the 1-year, 2-year and 5-year incidences of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) starting any of the biologic disease-modifying antirheumatic drugs (bDMARDs) currently available in clinical ...
Sleep problems in rheumatoid arthritis over 12 years from diagnosis : Results from the Swedish EIRA study

Lyne, Lauren; Åkerstedt, Torbjörn; Alfredsson, Lars; Lehtonen, Tiina; Sævarsdóttir, Sædís; Klareskog, Lars; Westerlind, Helga (2022-01-05)

Objective Most studies of rheumatoid arthritis (RA) and sleep have focused on established RA. We here investigate sleep quality and sleep duration in patients with newly diagnosed RA and during 1-12 years after diagnosis. Methods Data were collected ...
Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factors : results from the Swedish EIRA study

Hedenstierna, L.; Opava, C. H.; Askling, J.; Jiang, X.; Ernestam, S.; Alfredsson, L.; Klareskog, L.; Sævarsdóttir, Sædís (2021-01-12)

Objectives: To investigate whether low social support or low decision latitude at work correlate with risk of rheumatoid arthritis (RA), and whether and how those factors are associated with known modifiable risk factors for RA. Method: The Swedish ...
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritis : a combined analysis of multiple studies

Curtis, Jeffrey R.; Weinblatt, Michael E.; Shadick, Nancy A.; Brahe, Cecilie H.; Østergaard, Mikkel; Hetland, Merete Lund; Sævarsdóttir, Sædís; Horton, Megan; Mabey, Brent; Flake, Darl D.; Ben-Shachar, Rotem; Sasso, Eric H.; Huizinga, T. W. (2021-01-04)

BACKGROUND: The multi-biomarker disease activity (MBDA) test measures 12 serum protein biomarkers to quantify disease activity in RA patients. A newer version of the MBDA score, adjusted for age, sex, and adiposity, has been validated in two cohorts ...

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