IRIS: Recent submissions

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    Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure 
    Haraldsdóttir, Sigríður Ólína; Jonasson, Jon Gunnlaugur; Jorundsdottir, Kristin Bara; Hannesson, Haraldur Jon; Gislason, Thorarinn; Gudbjornsson, Bjorn (2021-10-01)
    Background This nationwide study aimed to elucidate the incidence and clinical characteristics of tissueverified sarcoidosis in Iceland. A secondary aim was to analyse sex differences and identify possible environmental factors contributing to the ...
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    A systematic review and meta-analysis evaluating the survival, the failure, and the complication rates of veneered and monolithic all-ceramic implant-supported single crowns 
    Pétursson, Bjarni Elvar; Sailer, Irena; Latyshev, Andrey; Rabel, Kerstin; Kohal, Ralf Joachim; Karasan, Duygu (2021-10)
    OBJECTIVE: To assess the survival, failure, and complication rates of veneered and monolithic all-ceramic implant-supported single crowns (SCs). METHODS: Literature search was conducted in Medline (PubMed), Embase, and Cochrane Central Register of ...
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    Fabrication, workflow and delivery of reconstruction : Summary and consensus statements of group 4. The 6th EAO Consensus Conference 2021 
    Jokstad, Asbjorn; Pétursson, Bjarni Elvar; Mühlemann, Sven; Wismeijer, Daniel; Wolfart, Stefan; Fehmer, Vincent; Güth, Jan Frederik; Holtzman, Lucrezia Paterno; Hämmerle, Christoph H.F.; Makarov, Nikolay; Meijer, Henny J.A.; Milinkovic, Iva; Sailer, Irena; Spitznagel, Frank A.; Vandeweghe, Stefan; de Velde, Tommie Van; Zwahlen, Marcel; Giertmuehlen, Petra C. (2021-10)
    Objectives: To report assessments of four systematic reviews (SRs) on (i) clinical outcomes of all-ceramic implant-supported crowns (iSCs), (ii) production time, effectiveness, and costs of computer-assisted manufacturing (CAM), (iii) computer-assisted ...
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    Ofþyngd þjóðar - hvað getum við gert? 
    Benediktsson, Rafn (2021-03)
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    Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen 
    Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eiríkur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
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    Genome-wide association study of circulating interleukin 6 levels identifies novel loci 
    Ahluwalia, Tarunveer S.; Prins, Bram P.; Abdollahi, Mohammadreza; Armstrong, Nicola J.; Aslibekyan, Stella; Bain, Lisa; Jefferis, Barbara; Baumert, Jens; Beekman, Marian; Ben-Shlomo, Yoav; Bis, Joshua C.; Mitchell, Braxton D.; De Geus, Eco; Delgado, Graciela E.; Marek, Diana; Eriksson, Joel; Kajantie, Eero; Kanoni, Stavroula; Kemp, John P.; Lu, Chen; Marioni, Riccardo E.; McLachlan, Stela; Milaneschi, Yuri; Nolte, Ilja M.; Petrelis, Alexandros M.; Porcu, Eleonora; Sabater-Lleal, Maria; Naderi, Elnaz; Seppälä, Ilkka; Shah, Tina; Singhal, Gaurav; Standl, Marie; Teumer, Alexander; Thalamuthu, Anbupalam; Thiering, Elisabeth; Trompet, Stella; Ballantyne, Christie M.; Benjamin, Emelia J.; Casas, Juan P.; Toben, Catherine; Dedoussis, George; Deelen, Joris; Durda, Peter; Engmann, Jorgen; Feitosa, Mary F.; Grallert, Harald; Hammarstedt, Ann; Harris, Sarah E.; Homuth, Georg; Guðnason, Vilmundur G. (2021-01-30)
    Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease ...
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    Abnormal glucose tolerance and lung function in children with cystic fibrosis. Comparing oral glucose tolerance test and continuous glucose monitoring 
    Elidottir, H.; Diemer, S.; Eklund, E.; Hansen, C. R. (2021-09)
    Background: Cystic fibrosis (CF) related diabetes (CFRD) is a common complication of CF. CFRD is associated with declining lung function even before its onset. Regular screening for CFRD using oral glucose tolerance test (OGTT) is recommended. Additionally, ...
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    Innleiðing gátlista vegna bráðra vandamála á skurðstofu á Sjúkrahúsinu á Akureyri: Viðhorfsrannsókn og samantekt á innleiðingarferli 
    Þorfinnsdóttir, Eyrún Björg; Sigurðardóttir, Árún Kristín; Sigurðsson, Martin Ingi (2022-03)
    Tilgangur: Það er mannlegt að gera mistök en mistök hafa í eðli sínu misalvarlegar afleiðingar. Rannsóknir sýna að hægt er að fyrirbyggja um 50% mistaka í svæfingum og skurðaðgerðum. Víðtækar rannsóknir hafa verið gerðar á því hvernig best sé að ...
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    Útskriftarvandi Landspítalans: Leit að lausnum fyrir aldraða sem lokið hafa meðferð 
    Hermannsdóttir, Guðfríður; Sigurðardóttir, Sigurveig H (2022-03)
    Tilgangur: Undanfarin ár hafa um og yfir 100 manns þurft að bíða eftir útskrift af Landspítalanum á hverjum tíma þó að meðferð þeirra sé lokið. Tilgangur rannsóknarinnar var að greina útskriftarvanda Landspítalans, hver áhrif hans væru og hvaða lausnir ...
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    Að efla virðingu í daglegri hjúkrun 
    Snjólaugsdóttir, Katrín Edda; Haraldsdottir, Erna (2022-03)
    Tilgangur :Tilgangur rannsóknarinnar var að skoða virðingu sem hluta af umönnun í heilbrigðisþjónustu með áherslu á að lýsa leiðum sem hjúkrunarfræðingar geta notað í daglegu starfi til að viðhalda og efla virðingu sjúklinga. Aðferð: Rýnirannsókn (e. ...
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    Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor 
    Dowsett, Joseph; Ferkingstad, Egil; Rasmussen, Line Jee Hartmann; Thørner, Lise Wegner; Magnússon, Magnús Karl; Sugden, Karen; Þorleifsson, Guðmar; Frigge, Mike; Burgdorf, Kristoffer Sølvsten; Ostrowski, Sisse Rye; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Hansen, Thomas Folkmann; Banasik, Karina; Brunak, Søren; Tragante, Vinicius; Lund, Sigrún Helga; Stefánsdóttir, Lilja; Gunnarson, Bjarni; Poulton, Richie; Arseneault, Louise; Caspi, Avshalom; Moffitt, Terrie E.; Gudbjartsson, Daníel Fannar; Eugen-Olsen, Jesper; Stefánsson, Hreinn; Stefánsson, Kári; Ullum, Henrik (2021-06-02)
    Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed ...
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    Áhrif lyfsins fampridíns á skerta göngugetu sjúklinga með MS (Multiple Sclerosis) 
    Guðjónsdóttir, Björg; Hjaltason, Haukur; Andrésdóttir, Guðbjörg Þóra (2021-04)
    INTRODUCTION: Fampridine is a drug for people with Multiple Sclerosis (MS). It is a broad-spectrum voltage-dependent potassium channel blocker that enhances synaptic transmission. The drug has been shown to be able to enhance conduction in demyelinated ...
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    Relationship between scoliosis, windswept hips and contractures with pain and asymmetries in sitting and supine in 2450 children with cerebral palsy 
    Casey, Jackie; Ágústsson, Atli; Rosenblad, Andreas; Rodby-Bousquet, Elisabet (2021-09-06)
    Purpose: This cross-sectional study of 2450 children with cerebral palsy aimed to analyse the prevalence and association of scoliosis, windswept hips, hip and knee contractures. Methods: Logistic regression was used to estimate associations with pain, ...
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    Clinical management of patients with drug-induced liver injury (DILI) 
    Björnsson, Einar Stefán (2021-06-28)
    Drug-induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. There is currently no biomarker that is helpful in diagnosis which relies on clinical ...
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    Predicting the probability of death using proteomics 
    Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...
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    Forysta sem samstarfsverkefni: áhersla skólastjóra á valddreifingu og samstarf 
    Hansen, Börkur; Lárusdóttir, Steinunn Helga (2019-12-15)
    Í nútímakenningum um skólastjórnun er kastljósinu jafnan beint að sýn skólastjóra á hlutverk sitt og tengsl við samstarfsfólk. Þá er átt við að skólastjórar og kennarar starfi saman að því að þróa skólastarf og kennsluhætti. Markmiðið með slíkum ...
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    Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity 
    Novotny, Ella N.; White, Samuel J.; Wilson, A. Douglas; Stefánsdóttir, Sara Björk; Tijhaar, Edwin; Jónsdóttir, Sigríður; Frey, Rebekka; Reiche, Dania; Rose, Horst; Rhyner, Claudio; Schüpbach-Regula, Gertraud; Þorsteinsdóttir, Sigurbjörg; Alcocer, Marcos; Marti, Eliane (2021-04)
    Background: Allergy to bites of blood-sucking insects, including biting midges, can affect both human and veterinary patients. Horses are often suffering from an IgE-mediated allergic dermatitis caused by bites of midges (Culicoides spp). With the aim ...
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    Þættir sem hafa áhrif á ákvörðun lækna um lyfjameðferð : Rannsókn í heilsugæslu á Íslandi 
    Ivarsdottir, Yrsa; Jónsson, Jón Steinar; Linnet, Kristjan; Blöndal, Anna Bryndís (2021-11-01)
    INTRODUCTION: This study aimed to analyse several factors that influence the decision-making of primary care physicians in Iceland in their choice of drug therapy for their patients. Also, to find which factors can act as a hindrance in making the best ...
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    Hvernig skynjum við sársauka? - Nóbelsverðlaun í lífeðlis- og læknisfræði 2021 
    Ólafsson, Elías (2021-11)
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    Replacement of traditional prothrombin time monitoring with the new Fiix prothrombin time increases the efficacy of warfarin without increasing bleeding. A review article 
    Önundarson, Páll Torfi; Palsson, Ragnar; Witt, Daniel M.; Gudmundsdottir, Brynja R. (2021-10-15)
    The antithrombotic effect of vitamin K antagonists (VKA) depends on controlled lowering of the activity of factors (F) II and X whereas reductions in FVII and FIX play little role. PT-INR based monitoring, however, is highly influenced by FVII, which ...