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Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients

Bruin, Gerard; Hockey, Hans Ulrich P.; La Stella, Phillip; Sigurgeirsson, Bárdur; Fu, Rong; Patekar, Manmath; Charef, Pascal; Woessner, Ralph; Boutouyrie-Dumont, Bruno (2020-02-01)

Aims: The aim of the study was to compare the pharmacokinetics (PK), safety and tolerability of secukinumab with different devices for subcutaneous (s.c.) administration of 2 mL. Methods: A phase 1 study in healthy subjects with 6 devices to administer ...
Management of Nail Disease in Patients With Psoriatic Arthritis : An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Laheru, Dhruvkumar; Antony, Anna; Carneiro, Sueli; Di Lernia, Vito; Garg, Amit; Löve, Þorvarður Jón; Del Rocio Macias Garcia, Karla; Mendonça, José Alexandre; Mukherjee, Sandeep; Olteanu, Rodica; Perez-Chada, Lourdes; Rosen, Cheryl F; Tannenbaum, Rachel; Yazbek, Michel Alexandre (2023-03-01)

OBJECTIVE: Nail psoriasis is common, impairs fine motor finger functioning, affects cosmesis, and is associated with a lower quality of life. This review updates the previous Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) ...
Risk Factors for Diagnosis of Psoriatic Arthritis, Psoriasis, Rheumatoid Arthritis, and Ankylosing Spondylitis : A Set of Parallel Case-control Studies

Meer, Elana; Thrastardottir, Telma; Wang, Xingmei; Dubreuil, Maureen; Chen, Yong; Gelfand, Joel M.; Love, Thorvardur J.; Ogdie, Alexis (2022-01-01)

Objective. To compare potential risk factors for the diagnosis of psoriatic arthritis (PsA), psoriasis (PsO), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). Methods. Four parallel case-control studies were conducted within The Health ...

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