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Factor B Mutation in Monozygotic Twins Discordant for Atypical Hemolytic Uremic Syndrome

Aradottir, Sigridur Sunna; Kristoffersson, Ann-Charlotte; Jensson, Brynjar O; Sulem, Patrick; Gong, Henning; Pálsson, Runólfur; Karpman, Diana (2023-05)
Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Aradottir, Sigridur Sunna; Kristoffersson, Ann Charlotte; Roumenina, Lubka T.; Bjerre, Anna; Kashioulis, Pavlos; Pálsson, Runólfur; Karpman, Diana (2021-06-10)

Complement factor B (FB) mutant variants are associated with excessive complement activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy and membranoproliferative glomerulonephritis (MPGN). Patients with aHUS ...

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