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Browsing by Subject "Molecular Medicine"

Browsing by Subject "Molecular Medicine"

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  • Kallab, Martin; Schuetzenberger, Kornelia; Hommer, Nikolaus; Schäfer, Bhavapriya Jasmin; Schmidl, Doreen; Bergmeister, Helga; Zeitlinger, Markus; Tan, Aimin; Jansook, Phatsawee; Loftsson, Þorsteinn; Stefánsson, Einar; Garhöfer, Gerhard (2021-05-18)
    The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in ...
  • Kristinsdottir, Iris; Haraldsson, Asgeir; Löve, Arthur; Asgeirsdottir, Tinna Laufey; Thors, Valtyr (Elsevier, 2021-08-09)
    Background: Acute gastroenteritis poses a significant burden on young children, families, health care facilities and societies. Rotavirus is the most common pathogen, but rotavirus infections are vaccine preventable. Information on the epidemiology of ...
  • Kulkarni, Amogh; Soni, Isha; Kelkar, Dhanashree S.; Dharmaraja, Allimuthu T.; Sankar, Rathinam K.; Beniwal, Gaurav; Rajendran, Abinaya; Tamhankar, Sharvari; Chopra, Sidharth; Kamat, Siddhesh S.; Chakrapani, Harinath (American Chemical Society (ACS), 2019-06-26)
    The alarming global rise in fatalities from multidrug-resistant Staphylococcus aureus (S. aureus) infections has underscored a need to develop new therapies to address this epidemic. Chemoproteomics is valuable in identifying targets for new drugs in ...
  • Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eirikur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
  • Zhang, Li; Pilarowski, Genay; Pich, Emilio Merlo; Nakatani, Atsushi; Dunlop, John; Baba, Rina; Matsuda, Satoru; Daini, Masaki; Hattori, Yasushi; Matsumoto, Shigemitsu; Ito, Mitsuhiro; Kimura, Haruhide; Björnsson, Hans Tómas (2021-03-12)
    Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D ( KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown that ...
  • Kalinousky, Allison; Rapp, Tyler; Hijazi, Hadia; Johnson, Jennifer; Björnsson, Hans Tómas; Harris, Jacqueline R. (2022-10-06)
    Kabuki syndrome (KS) is a Mendelian Disorder of the Epigenetic Machinery (MDEM) caused by loss of function variants in either of two genes involved in the regulation of histone methylation, KMT2D (34–76%) or KDM6A (9–13%). Previously, representative ...
  • Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Døskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (2021-05)
    Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin ( 3) and myxin ( 4) exhibit potent and hypoxia-selective cell death on ...
  • Kricker, Jennifer A.; Page, Clive P.; Gardarsson, Fridrik Runar; Baldursson, Olafur; Guðjónsson, Þórarinn; Parnham, Michael J. (2021)
    Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly for respiratory infections. It is now recognized that these drugs, in particular azithromycin, also exert time-dependent immunomodulatory actions that contribute ...
  • Neumann, Bjoern; Foerster, Sarah; Zhao, Chao; Bodini, Benedetta; Reich, Daniel S.; Bergles, Dwight E.; Káradóttir, Ragnhildur Þóra; Lubetzki, Catherine; Lairson, Luke L.; Zalc, Bernard; Stankoff, Bruno; Franklin, Robin J.M. (2020-05-07)
    Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss ...
  • Ng, Rowena; Björnsson, Hans Tómas; Fahrner, Jill A.; Harris, Jacqueline R. (2022-10-13)
    Wiedemann-Steiner syndrome (WSS) is a rare genetic disorder caused by mutation in KMT2A and characterized by neurodevelopmental delay. This study is the first prospective investigation to examine the sleep and behavioral phenotypes among those with WSS ...
  • Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit (2021-03-03)
    T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel ...