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Browsing by Subject "Molecular Medicine"

Browsing by Subject "Molecular Medicine"

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  • Kallab, Martin; Schuetzenberger, Kornelia; Hommer, Nikolaus; Schäfer, Bhavapriya Jasmin; Schmidl, Doreen; Bergmeister, Helga; Zeitlinger, Markus; Tan, Aimin; Jansook, Phatsawee; Loftsson, Þorsteinn; Stefánsson, Einar; Garhöfer, Gerhard (2021-05-18)
    The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in ...
  • Kristinsdottir, Iris; Haraldsson, Asgeir; Löve, Arthur; Asgeirsdottir, Tinna Laufey; Thors, Valtyr (Elsevier, 2021-08-09)
    Background: Acute gastroenteritis poses a significant burden on young children, families, health care facilities and societies. Rotavirus is the most common pathogen, but rotavirus infections are vaccine preventable. Information on the epidemiology of ...
  • Kulkarni, Amogh; Soni, Isha; Kelkar, Dhanashree S.; Dharmaraja, Allimuthu T.; Sankar, Rathinam K.; Beniwal, Gaurav; Rajendran, Abinaya; Tamhankar, Sharvari; Chopra, Sidharth; Kamat, Siddhesh S.; Chakrapani, Harinath (American Chemical Society (ACS), 2019-06-26)
    The alarming global rise in fatalities from multidrug-resistant Staphylococcus aureus (S. aureus) infections has underscored a need to develop new therapies to address this epidemic. Chemoproteomics is valuable in identifying targets for new drugs in ...
  • Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eirikur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
  • Zhang, Li; Pilarowski, Genay; Pich, Emilio Merlo; Nakatani, Atsushi; Dunlop, John; Baba, Rina; Matsuda, Satoru; Daini, Masaki; Hattori, Yasushi; Matsumoto, Shigemitsu; Ito, Mitsuhiro; Kimura, Haruhide; Björnsson, Hans Tómas (2021-03-12)
    Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D ( KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown that ...
  • Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Døskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (2021-05)
    Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin ( 3) and myxin ( 4) exhibit potent and hypoxia-selective cell death on ...
  • Kricker, Jennifer A.; Page, Clive P.; Gardarsson, Fridrik Runar; Baldursson, Olafur; Guðjónsson, Þórarinn; Parnham, Michael J. (2021)
    Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly for respiratory infections. It is now recognized that these drugs, in particular azithromycin, also exert time-dependent immunomodulatory actions that contribute ...
  • Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit (2021-03-03)
    T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel ...