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Browsing by Subject "Immunology and Allergy"

Browsing by Subject "Immunology and Allergy"

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    Abatacept in rheumatoid arthritis : Survival on drug, clinical outcomes, and their predictors - Data from a large national quality register 
    Cagnotto, Giovanni; Willim, Minna; Nilsson, Jan Åke; Compagno, Michele; Jacobsson, Lennart T.H.; Saevarsdottir, Saedis; Turesson, Carl (2020-01-22)
    Background: There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inhibition in clinical practice. ...
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    Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells : Implications for a Bacterial Origin in RA Etiology 
    Sherina, Natalia; de Vries, Charlotte; Kharlamova, Nastya; Sippl, Natalie; Jiang, Xia; Brynedal, Boel; Kindstedt, Elin; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Stålesen, Ragnhild; Saevarsdottir, Saedis; Holmdahl, Rikard; Hensvold, Aase; Johannsen, Gunnar; Eriksson, Kaja; Sallusto, Federica; Catrina, Anca I.; Rönnelid, Johan; Grönwall, Caroline; Yucel-Lindberg, Tülay; Alfredsson, Lars; Klareskog, Lars; Piccoli, Luca; Malmström, Vivianne; Amara, Khaled; Lundberg, Karin (2022-04-20)
    Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
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    Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis : results from the SWEFOT trial population 
    for the SWEFOT study group (2019-09-03)
    Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and ...
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    Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 
    Spiliopoulou, Athina; Colombo, Marco; Plant, Darren; Nair, Nisha; Cui, Jing; Coenen, Marieke J.H.; Ikari, Katsunori; Yamanaka, Hisashi; Saevarsdottir, Saedis; Padyukov, Leonid; Bridges, S. Louis; Kimberly, Robert P.; Okada, Yukinori; Van Riel, Piet L.C.M.; Wolbink, Gertjan; Van Der Horst-Bruinsma, Irene E.; De Vries, Niek; Tak, Paul P.; Ohmura, Koichiro; Canhão, Helena; Guchelaar, Henk Jan; Huizinga, Tom W.J.; Criswell, Lindsey A.; Raychaudhuri, Soumya; Weinblatt, Michael E.; Wilson, Anthony G.; Mariette, Xavier; Isaacs, John D.; Morgan, Ann W.; Pitzalis, Costantino; Barton, Anne; Mckeigue, Paul (2019-08-01)
    Objectives We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these ...
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    Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance 
    Sigurbergsdóttir, Aðalbjörg Ýr; Löve, Þorvarður Jón; Kristinsson, Sigurður Yngvi (2022-04-28)
    Various epidemiological studies, including case reports and -series in addition to larger, population-based studies, have reported an increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma in individuals ...
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    Clinical Remission of Asthma and Allergic Rhinitis-in a Longitudinal Population Study 
    Heldin, Johanna; Malinovschi, Andrei; Johannessen, Ane; Alving, Kjell; Holm, Mathias; Franklin, Karl A.; Forsberg, Bertil; Schlünssen, Vivi; Jögi, Rain; Gíslason, Þórarinn; Benediktsdóttir, Bryndís; Svanes, Cecilie; Janson, Christer (2022)
    Background: Although asthma and allergic rhinitis are chronic diseases, some patients experience periods of remission. Information on prognostic factors associated with the remission of asthma and allergic rhinitis is valuable in resource prioritization. ...
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    A comparative study of adjuvants effects on neonatal plasma cell survival niche in bone marrow and persistence of humoral immune responses 
    Pind, Auður Anna Aradóttir; Thorsdottir, Sigrun; Magnusdottir, Gudbjorg Julia; Meinke, Andreas; Del Giudice, Giuseppe; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2022-08-03)
    The neonatal immune system is distinct from the immune system of older individuals rendering neonates vulnerable to infections and poor responders to vaccination. Adjuvants can be used as tools to enhance immune responses to co-administered antigens. ...
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    Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity 
    Novotny, Ella N.; White, Samuel J.; Wilson, A. Douglas; Stefánsdóttir, Sara Björk; Tijhaar, Edwin; Jónsdóttir, Sigríður; Frey, Rebekka; Reiche, Dania; Rose, Horst; Rhyner, Claudio; Schüpbach-Regula, Gertraud; Þorsteinsdóttir, Sigurbjörg; Alcocer, Marcos; Marti, Eliane (2021-04)
    Background: Allergy to bites of blood-sucking insects, including biting midges, can affect both human and veterinary patients. Horses are often suffering from an IgE-mediated allergic dermatitis caused by bites of midges (Culicoides spp). With the aim ...
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    A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis 
    Grönwall, Caroline; Liljefors, Lisa; Bang, Holger; Hensvold, Aase H.; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Joshua, Vijay; Svärd, Anna; Stålesen, Ragnhild; Titcombe, Philip J.; Steen, Johanna; Piccoli, Luca; Sherina, Natalia; Clavel, Cyril; Svenungsson, Elisabet; Gunnarsson, Iva; Sævarsdóttir, Sædís; Kastbom, Alf; Serre, Guy; Alfredsson, Lars; Malmström, Vivianne; Rönnelid, Johan; Catrina, Anca I.; Lundberg, Karin; Klareskog, Lars (2021-05-20)
    Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. ...
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    Detailed Multiplex Analysis of SARS-CoV-2 Specific Antibodies in COVID-19 Disease 
    Brynjólfsson, Siggeir Fannar; Sigurgrímsdóttir, Hildur; Einarsdóttir, Elín D.; Björnsdóttir, Guðrún Ása; Ármannsdóttir, Brynja; Baldvinsdóttir, Guðrún E.; Bjarnason, Agnar; Guðlaugsson, Ólafur; Guðmundsson, Sveinn Viðar; Sigurðardóttir, Sigurveig T.; Löve, Arthur; Kristinsson, Karl Gústaf; Lúðvíksson, Björn Rúnar (2021-06-10)
    A detailed understanding of the antibody response against SARS-CoV-2 is of high importance, especially with the emergence of novel vaccines. A multiplex-based assay, analyzing IgG, IgM, and IgA antibodies against the receptor binding domain (RBD), spike ...
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    Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis 
    Haugen, Ida K.; Felson, David T.; Abhishek, Abhishek; Berenbaum, Francis; Bierma-Zeinstra, Sita; Borgen, Tove; Herrero Beaumont, Gabriel; Ishimori, Mariko; Jonsson, Helgi; Kroon, Féline P.B.; Maheu, Emmanuel; Ramonda, Roberta; Ritschl, Valentin; Stamm, Tanja A.; Van Der Heijde, Desirée; Wittoek, Ruth; Greibrokk, Elsie; Smeets, Wilma; Kloppenburg, Margreet (2020-06-25)
    Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. Methods In a cross-sectional multi-centre international study, a convenience sample of patients ...
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    Development of radiographic classification criteria for hand osteoarthritis : a methodological report (Phase 2) 
    Haugen, Ida K.; Felson, David; Abhishek, Abhishek; Berenbaum, Francis; Edwards, John James; Herrero Beaumont, Gabriel; Hermann-Eriksen, Merete; Hill, Catherine L.; Ishimori, Mariko; Jonsson, Helgi; Karjalainen, Teemu; Leung, Ying Ying; Maheu, Emmanuel; Mallen, Christian D.; Moe, Rikke Helene; Ramonda, Roberta; Ritschl, Valentin; Stamm, Tanja A.; Szekanecz, Zoltan; van der Giesen, Florus J.; Ritt, Marco J.P.F.; Wittoek, Ruth; Kjeken, Ingvild; Osteras, Nina; van de Stadt, Lotte A.; Englund, Martin; Dziedzic, Krysia S.; Marshall, M.; Bierma-Zeinstra, Sita; Hansen, Paul; Greibrokk, Elsie; Smeets, Wilma; Kloppenburg, Margreet (2022-02-04)
    ObjectivesIn Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. Radiographic findings could better discriminate patients with hand OA and ...
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    Dietary Fish Oil Increases the Number of CD11b+CD27− NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced Peritonitis 
    Jensen, Kirstine Nolling; Heijink, Marieke; Giera, Martin; Freysdóttir, Jóna; Harðardóttir, Ingibjörg (2022-01-01)
    Purpose: To determine the effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on recruitment of natural killer (NK) cells and resolution responses in antigen-induced peritonitis in mice. Methods: Mice were fed fish oil-enriched or control ...
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    Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component? 
    Sysojev, Anton Öberg; Frisell, Thomas; Delcoigne, Bénédicte; Saevarsdottir, Saedis; Askling, Johan; Westerlind, Helga (2022-08-06)
    Objectives: To assess whether persistence to treatment with methotrexate (MTX) in early rheumatoid arthritis (RA) is shared among first-degree relatives with RA and to estimate any underlying heritability. Methods: First-degree relative pairs diagnosed ...
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    Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration 
    Lindström, Ulf; Di Giuseppe, Daniela; Delcoigne, Bénédicte; Glintborg, Bente; Möller, Burkhard; Ciurea, Adrian; Pombo-Suarez, Manuel; Sanchez-Piedra, Carlos; Eklund, Kari; Relas, Heikki; Guðbjörnsson, Björn; Löve, Þorvarður Jón; Jones, Gareth T.; Codreanu, Catalin; Ionescu, Ruxandra; Nekvindova, Lucie; Závada, Jakub; Atas, Nuh; Yolbas, Servet; Fagerli, Karen Minde; Michelsen, Brigitte; Rotar, Ziga; Tomšič, Matija; Iannone, Florenzo; Santos, Maria Jose; Avila-Ribeiro, Pedro; Ørnbjerg, Lykke Midtbøll; Østergaard, Mikkel; Jacobsson, Lennart T.H.; Askling, Johan; Nissen, Michael J. (2021-06-03)
    Background Comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) during treatment with tumour necrosis factor inhibitors (TNFi) is extensively used in psoriatic arthritis (PsA), although the additive benefit remains ...
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    Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis 
    Aradottir, Sigridur Sunna; Kristoffersson, Ann Charlotte; Roumenina, Lubka T.; Bjerre, Anna; Kashioulis, Pavlos; Pálsson, Runólfur; Karpman, Diana (2021-06-10)
    Complement factor B (FB) mutant variants are associated with excessive complement activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy and membranoproliferative glomerulonephritis (MPGN). Patients with aHUS ...
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    Hematopoietic Stem Cell Transplantation Resolves the Immune Deficit Associated with STAT3-Dominant-Negative Hyper-IgE Syndrome 
    Harrison, Stephanie C.; Tsilifis, Christo; Slatter, Mary A.; Nademi, Zohreh; Worth, Austen; Veys, Paul; Ponsford, Mark J.; Jolles, Stephen; Al-Herz, Waleed; Flood, Terence; Cant, Andrew J.; Doffinger, Rainer; Barcenas-Morales, Gabriela; Carpenter, Ben; Hough, Rachael; Haraldsson, Ásgeir; Heimall, Jennifer; Grimbacher, Bodo; Abinun, Mario; Gennery, Andrew R. (2021-02-01)
    Autosomal dominant hyper-IgE syndrome caused by dominant-negative loss-of-function mutations in signal transducer and activator of transcription factor 3 (STAT3) (STAT3-HIES) is a rare primary immunodeficiency with multisystem pathology. The quality ...
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    Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study 
    Westerlind, Helga; Palmqvist, Ida; Saevarsdottir, Saedis; Alfredsson, Lars; Klareskog, Lars; Di Giuseppe, Daniela (2021-08-07)
    BACKGROUND: Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, ...
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    Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs 
    Framme, Jenny Lingman; Lundqvist, Christina; Lundell, Anna Carin; van Schouwenburg, Pauline A.; Lemarquis, Andri L.; Thörn, Karolina; Lindgren, Susanne; Gudmundsdottir, Judith; Lundberg, Vanja; Degerman, Sofie; Zetterström, Rolf H.; Borte, Stephan; Hammarström, Lennart; Telemo, Esbjörn; Hultdin, Magnus; van der Burg, Mirjam; Fasth, Anders; Oskarsdóttir, Sólveig; Ekwall, Olov (2022-01-26)
    Background: Population-based neonatal screening using T-cell receptor excision circles (TRECs) identifies infants with profound T lymphopenia, as seen in cases of severe combined immunodeficiency, and in a subgroup of infants with 22q11 deletion syndrome ...
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    LT-K63 Enhances B Cell Activation and Survival Factors in Neonatal Mice That Translates Into Long-Lived Humoral Immunity 
    Aradottir Pind, Audur Anna; Molina Estupiñan, Jenny Lorena; Magnusdottir, Gudbjorg Julia; Del Giudice, Giuseppe; Jonsdottir, Ingileif; Bjarnarson, Stefania P. (2020-10-23)
    Adjuvants enhance magnitude and duration of immune responses induced by vaccines. In this study we assessed in neonatal mice if and how the adjuvant LT-K63 given with a pneumococcal conjugate vaccine, Pnc1-TT, could affect the expression of tumor ...