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Browsing by Subject "Frumulíffræði"

Browsing by Subject "Frumulíffræði"

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  • Ísberg, Ólöf Gerður; Kim, Jiyoung; Fridriksdottir, Agla; Morsing, Mikkel; Timmermans-Wielenga, Vera; Rønnov-Jessen, Lone; Petersen, Ole W.; Villadsen, René (Springer Science and Business Media LLC, 2019-10-16)
    Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol ...
  • Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
  • Rekha, Rokeya Sultana; Mily, Akhirunnesa; Sultana, Tajnin; Haq, Ahsanul; Ahmed, Sultan; Mostafa Kamal, S. M.; van Schadewijk, Annemarie; Hiemstra, Pieter S.; Guðmundsson, Guðmundur Hrafn; Agerberth, Birgitta; Raqib, Rubhana (Springer Nature, 2018-07-04)
    Background We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum culture conversion and increased ...
  • Foxler, Daniel E.; Bridge, Katherine S.; James, Victoria; Webb, Thomas M.; Mee, Maureen; Wong, Sybil C. K.; Feng, Yunfeng; Constantin-Teodosiu, Dumitru; Petursdottir, Thorgunnur Eyfjord; Bjornsson, Johannes; Ingvarsson, Sigurður; Ratcliffe, Peter J.; Longmore, Gregory D.; Sharp, Tyson V. (Springer Nature, 2012-01-29)
    There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate ...
  • Kristjánsdóttir, Þórdís; Bosma, Elleke F.; Branco dos Santos, Filipe; Özdemir, Emre; Herrgård, Markus J.; França, Lucas; Ferreira, Bruno; Nielsen, Alex T.; Guðmundsson, Steinn (Springer Science and Business Media LLC, 2019-10-29)
    Background: Lactobacillus reuteri is a heterofermentative Lactic Acid Bacterium (LAB) that is commonly used for food fermentations and probiotic purposes. Due to its robust properties, it is also increasingly considered for use as a cell factory. It ...
  • Zhang, T.; Zhou, Q.; Ogmundsdottir, Margret H; Möller, Katrín; Siddaway, R.; Larue, L.; Hsing, M.; Kong, S. W.; Goding, C. R.; Palsson, Arnar; Steingrimsson, Eirikur; Pignoni, F. (The Company of Biologists, 2015-06-19)
    The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we ...
  • Myszor, Iwona T.; Parveen, Zahida; Ottosson, Håkan; Bergman, Peter; Agerberth, Birgitta; Strömberg, Roger; Guðmundsson, Guðmundur H. (Springer Science and Business Media LLC, 2019-05-08)
    Aroylated phenylenediamines (APDs) are novel inducers of innate immunity enhancing cathelicidin gene expression in human bronchial epithelial cell lines. Here we present two newly developed APDs and aimed at defning the response and signaling pathways ...
  • Morera, Erika; Steinhäuser, Sarah Sophie; Budkova, Zuzana; Ingthorsson, Saevar; Kricker, Jennifer; Krueger, Aileen; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn (Springer Science and Business Media LLC, 2019-09-03)
    Epithelial to mesenchymal transition (EMT) is a developmental event that is hijacked in some diseases such as fibrosis and cancer. In cancer, EMT has been linked to increased invasion and metastasis and is generally associated with a poor prognosis. ...