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Browsing by Subject "Biochemistry, Genetics and Molecular Biology (all)"

Browsing by Subject "Biochemistry, Genetics and Molecular Biology (all)"

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  • Daníelsdóttir, Hilda Björk; Aspelund, Thor; Thordardottir, Edda Bjork; Fall, Katja; Fang, Fang; Tómasson, Gunnar; Rúnarsdóttir, Harpa; Yang, Qian; Choi, Karmel W; Kennedy, Beatrice; Halldorsdottir, Thorhildur; Lu, Donghao; Song, Huan; Jakobsdóttir, Jóhanna; Hauksdóttir, Arna; Valdimarsdóttir, Unnur Anna (2022-02-01)
    Background: Adverse childhood experiences (ACEs) have consistently been associated with elevated risk of multiple adverse health outcomes, yet their contribution to coping ability and psychiatric resilience in adulthood is unclear. Methods: Cross-sectional ...
  • Aoki, Kagari; Isojunno, Saana; Bellot, Charlotte; Iwata, Takashi; Kershaw, Joanna; Akiyama, Yu; Martín López, Lucía M.; Ramp, Christian; Biuw, Martin; Swift, René; Wensveen, Paulus Jacobus; Pomeroy, Patrick; Narazaki, Tomoko; Hall, Ailsa; Sato, Katsufumi; Miller, Patrick J.O. (2021-01-27)
    Monitoring the body condition of free-ranging marine mammals at different life-history stages is essential to understand their ecology as they must accumulate sufficient energy reserves for survival and reproduction. However, assessing body condition ...
  • Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
  • Eriksson, Kimmo; Strimling, Pontus; Gelfand, Michele; Wu, Junhui; Abernathy, Jered; Akotia, Charity S.; Aldashev, Alisher; Andersson, Per A.; Andrighetto, Giulia; Anum, Adote; Arikan, Gizem; Aycan, Zeynep; Bagherian, Fatemeh; Barrera, Davide; Basnight-Brown, Dana; Batkeyev, Birzhan; Belaus, Anabel; Berezina, Elizaveta; Björnstjerna, Marie; Blumen, Sheyla; Boski, Paweł; Bou Zeineddine, Fouad; Bovina, Inna; Huyen, Bui Thi Thu; Cardenas, Juan Camilo; Čekrlija, Đorđe; Choi, Hoon Seok; Contreras-Ibáñez, Carlos C.; Costa-Lopes, Rui; de Barra, Mícheál; de Zoysa, Piyanjali; Dorrough, Angela; Dvoryanchikov, Nikolay; Eller, Anja; Engelmann, Jan B.; Euh, Hyun; Fang, Xia; Fiedler, Susann; Foster-Gimbel, Olivia A.; Fülöp, Márta; Garðarsdóttir, Ragna Benedikta; Gill, C. M.Hew D.; Glöckner, Andreas; Graf, Sylvie; Grigoryan, Ani; Gritskov, Vladimir; Growiec, Katarzyna; Halama, Peter; Hartanto, Andree; Hopthrow, Tim (2021-04-26)
    The original version of this Article contained an error in the author affiliations. Cecilia Reyna was incorrectly associated with ‘Universidad Nacional de Córdoba (UNC). Facultad de Psicología (UNC), Ciudad Universitaria, Bv. de la Reforma esquina, ...
  • Fatty Acids and Outcomes Research Consortium (FORCE) (2021-04-22)
    The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and ...
  • Hamm, Michael; Sohier, Pierre; Petit, Valérie; Raymond, Jérémy H.; Delmas, Véronique; Le Coz, Madeleine; Gesbert, Franck; Kenny, Colin; Aktary, Zackie; Pouteaux, Marie; Rambow, Florian; Sarasin, Alain; Charoenchon, Nisamanee; Bellacosa, Alfonso; Sanchez-del-Campo, Luis; Mosteo, Laura; Lauss, Martin; Meijer, Dies; Steingrímsson, Eiríkur; Jönsson, Göran B.; Cornell, Robert A.; Davidson, Irwin; Goding, Colin R.; Larue, Lionel (2021-06-17)
    While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling ...
  • Emilsson, Valur; Gudmundsdottir, Valborg; Gudjonsson, Alexander; Jonmundsson, Thorarinn; Jonsson, Brynjolfur G; Karim, Mohd A; Ilkov, Marjan; Staley, James R; Gudmundsson, Elias F; Launer, Lenore J; Lindeman, Jan H; Morton, Nicholas M; Aspelund, Thor; Lamb, John R; Jennings, Lori L; Gudnason, Vilmundur (2022-01-25)
    Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current study, 54,469 low-frequency and common ...
  • Kamen, Yasmine; Káradóttir, Ragnhildur Þóra (2021-06-18)
    Single-cell electrophysiological recordings combined with dye loading and immunohistochemistry provide unparalleled single-cell resolution of cell physiology, morphology, location, and protein expression. When correlated with bulk RNA sequencing, these ...
  • GEMO Study Collaborators; EMBRACE Collaborators; SWE-BRCA Investigators; kConFab Investigators; HEBON Investigators (2022-10-06)
    The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 ...
  • Olsen, S. F.; Halldorsson, T. I.; Thorne-Lyman, A. L.; Strøm, M.; Gørtz, S.; Granstrøm, C.; Nielsen, P. H.; Wohlfahrt, J.; Lykke, J. A.; Langhoff-Roos, J.; Cohen, A. S.; Furtado, J. D.; Giovannucci, E. L.; Zhou, W. (2020-01-01)
  • arcOGEN consortium; HUNT All-In Pain; ARGO Consortium; Regeneron Genetics Center; Babis, George C; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A; Samartzis, Dino; Slagboom, P Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H; Uitterlinden, André G; Winsvold, Bendik; Zwart, John-Anker; Davey Smith, George; Sham, Pak Chung; Thorleifsson, Gudmar; Gaunt, Tom R; Morris, Andrew P; Valdes, Ana M; Tsezou, Aspasia; Cheah, Kathryn S E; Ikegawa, Shiro; Hveem, Kristian; Esko, Tõnu; Wilkinson, J Mark; Meulenbelt, Ingrid; Lee, Ming Ta Michael; van Meurs, Joyce B J; Styrkársdóttir, Unnur; Zeggini, Eleftheria (2021-09-01)
    Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 ...
  • Lifelines Cohort Study; DiscovEHR/MyCode study; VA Million Veteran Program (2022-06-13)
    Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based ...
  • Norddahl, Gudmundur L.; Melsted, Páll; Gunnarsdottir, Kristbjorg; Halldórsson, Gísli Hreinn; Olafsdottir, Thorunn; Gylfason, Arnaldur; Kristjánsson, Már; Magnusson, Olafur T.; sulem, patrick; Gudbjartsson, Daniel Fannar; Þorsteinsdóttir, Unnur; Jónsdóttir, Ingileif; Stefánsson, Kári (2022-09-28)
    By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in ...
  • Lindström, Ulf; Di Giuseppe, Daniela; Delcoigne, Bénédicte; Glintborg, Bente; Möller, Burkhard; Ciurea, Adrian; Pombo-Suarez, Manuel; Sanchez-Piedra, Carlos; Eklund, Kari; Relas, Heikki; Guðbjörnsson, Björn; Löve, Þorvarður Jón; Jones, Gareth T.; Codreanu, Catalin; Ionescu, Ruxandra; Nekvindova, Lucie; Závada, Jakub; Atas, Nuh; Yolbas, Servet; Fagerli, Karen Minde; Michelsen, Brigitte; Rotar, Ziga; Tomšič, Matija; Iannone, Florenzo; Santos, Maria Jose; Avila-Ribeiro, Pedro; Ørnbjerg, Lykke Midtbøll; Østergaard, Mikkel; Jacobsson, Lennart T.H.; Askling, Johan; Nissen, Michael J. (2021-06-03)
    Background Comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) during treatment with tumour necrosis factor inhibitors (TNFi) is extensively used in psoriatic arthritis (PsA), although the additive benefit remains ...
  • Dowsett, Joseph; Ferkingstad, Egil; Rasmussen, Line Jee Hartmann; Thørner, Lise Wegner; Magnússon, Magnús Karl; Sugden, Karen; Þorleifsson, Guðmar; Frigge, Mike; Burgdorf, Kristoffer Sølvsten; Ostrowski, Sisse Rye; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Hansen, Thomas Folkmann; Banasik, Karina; Brunak, Søren; Tragante, Vinicius; Lund, Sigrún Helga; Stefánsdóttir, Lilja; Gunnarson, Bjarni; Poulton, Richie; Arseneault, Louise; Caspi, Avshalom; Moffitt, Terrie E.; Gudbjartsson, Daníel Fannar; Eugen-Olsen, Jesper; Stefánsson, Hreinn; Stefánsson, Kári; Ullum, Henrik (2021-06-02)
    Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed ...
  • HUNT All-In Pain; ARGO Consortium; Regeneron Genetics Center; arcOGEN consortium (2021-11-24)
    (Cell 184, 4784–4818.e1–e16, September 2, 2021) In this article, we carried out a multi-cohort GWAS meta-analysis for 11 osteoarthritis phenotypes. Since publication, we have become aware of the following typographical errors that were introduced during ...
  • The PRACTICAL consortium (2019-12-01)
    The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions ...
  • Oskarsson, Gudjon R.; Magnusson, Magnus K.; Oddsson, Asmundur; Jensson, Brynjar O.; Fridriksdottir, Run; Arnadottir, Gudny A.; Katrinardottir, Hildigunnur; Rognvaldsson, Solvi; Halldorsson, Gisli H.; Sveinbjornsson, Gardar; Ivarsdottir, Erna V.; Stefansdottir, Lilja; Ferkingstad, Egil; Norland, Kristjan; Tragante, Vinicius; Saemundsdottir, Jona; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Sigurjonsdottir, Svanhvit; Petursdottir, Karen O.; Davidsson, Olafur B.; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Onundarson, Pall T.; Vidarsson, Brynjar; Sigurdardottir, Olof; Masson, Gisli; Gudbjartsson, Daniel F.; Jonsdottir, Ingileif; Norddahl, Gudmundur L.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari (2022-06-01)
    The characteristic lobulated nuclear morphology of granulocytes is partially determined by composition of nuclear envelope proteins. Abnormal nuclear morphology is primarily observed as an increased number of hypolobulated immature neutrophils, called ...
  • FINNPEC Consortium; GOPEC Consortium (2020-12)
    Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal ...
  • DBDS Genetic Consortium (2022-03-24)
    Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and has a largely unknown underlying biology. In a genome-wide association study of CTS (48,843 cases and 1,190,837 controls), we found 53 sequence variants at 50 loci associated ...