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Browsing by Journal title "Autophagy Reports"

Browsing by Journal title "Autophagy Reports"

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    A novel region within a conserved domain in ATG7 emerged in vertebrates 
    Hjaltalin, Valgerdur; Pogenberg, Vivian; Ostacolo, Kevin; Palsson, Arnar; Ogmundsdottir, Margret H. (Informa, 2022-09-07)
    The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is a highly conserved degradation pathway important for maintaining homeostasis in eukaryotic cells. Here, we study the evolution of E1 enzymes and ...
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    PINK1 regulated mitophagy is evident in skeletal muscles 
    Singh, Francois; Wilhelm, Lea; Prescott, Alan R.; Ostacolo, Kevin; Zhao, Jin-Feng; Ogmundsdottir, Margret H.; Ganley, Ian G. (Informa, 2024-03-11)
    PINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most ...