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Fletta eftir deild "Faculty of Medicine"

Fletta eftir deild "Faculty of Medicine"

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    Abatacept in rheumatoid arthritis : Survival on drug, clinical outcomes, and their predictors - Data from a large national quality register 
    Cagnotto, Giovanni; Willim, Minna; Nilsson, Jan Åke; Compagno, Michele; Jacobsson, Lennart T.H.; Saevarsdottir, Saedis; Turesson, Carl (2020-01-22)
    Background: There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inhibition in clinical practice. ...
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    ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19 
    Emilsson, Valur; Gudmundsson, Elias F; Aspelund, Thor; Jonsson, Brynjolfur G; Gudjonsson, Alexander; Launer, Lenore J.; Lamb, John R; Gudmundsdottir, Valborg; Jennings, Lori L; Gudnason, Vilmundur (2020-06-05)
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    Acetylsalicylic acid use is associated with improved survival in bacteremic pneumococcal pneumonia : A long-term nationwide study 
    Rögnvaldsson, Kristján Godsk; Bjarnason, Agnar; Kristinsson, Karl Gústaf; Bragason, Hörður T; Erlendsdóttir, Helga; Þorgeirsson, Guðmundur; Gottfreðsson, Magnús (2022-08)
    BACKGROUND: Pneumonia is commonly caused by Streptococcus pneumoniae (pneumococcus) and associated with subsequent cardiovascular complications and increased mortality. Potential short-term survival benefits conferred by acetylsalicylic acid (ASA) use ...
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    Active conventional treatment and three different biological treatments in early rheumatoid arthritis : Phase IV investigator initiated, randomised, observer blinded clinical trial 
    Hetland, Merete Lund; Haavardsholm, Espen A.; Rudin, Anna; Nordström, Dan; Nurmohamed, Michael; Gudbjornsson, Bjorn; Lampa, Jon; Hørslev-Petersen, Kim; Uhlig, Till; Grondal, Gerdur; Østergaard, Mikkel; Heiberg, Marte S.; Twisk, Jos; Lend, Kristina; Krabbe, Simon; Hyldstrup, Lise Hejl; Lindqvist, Joakim; Hultgård Ekwall, Anna Karin; Grøn, Kathrine Lederballe; Kapetanovic, Meliha; Faustini, Francesca; Tuompo, Riitta; Lorenzen, Tove; Cagnotto, Giovanni; Baecklund, Eva; Hendricks, Oliver; Vedder, Daisy; Sokka-Isler, Tuulikki; Husmark, Tomas; Ljoså, Maud Kristine Aga; Brodin, Eli; Ellingsen, Torkell; Söderbergh, Annika; Rizk, Milad; Olsson, Åsa Reckner; Larsson, Per; Uhrenholt, Line; Just, Søren Andreas; Stevens, David John; Laurberg, Trine Bay; Bakland, Gunnstein; Olsen, Inge C.; Van Vollenhoven, Ronald (2020-12-02)
    AbstractObjective To evaluate and compare benefits and harms of three biological treatments with different modes of action versus active conventional treatment in patients with early rheumatoid arthritis. Design Investigator initiated, randomised, open ...
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    Activity of osimertinib in a patient with stage IV non-small cell lung cancer harboring HER2 exon 19, p.L755P mutation : case report 
    Jonsdottir, Gudbjorg; Smith, Mark; Wood, Samuel; Hejleh, Taher Abu; Furqan, Muhammad (2023-04-27)
    Background: Recurrent in-frame insertions within exon 20 causing duplication of amino acids Tyrosine-Valine-Methionine-Alanine (YVMA) represent 80% of all HER2 alterations in non-small cell lung cancer (NSCLC). HER2 tyrosine kinase inhibitors (TKI), ...
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    Activity-dependent alteration of early myelin ensheathment in a developing sensory circuit 
    Chorghay, Zahraa; MacFarquhar, David; Li, Vanessa J.; Aufmkolk, Sarah; Schohl, Anne; Wiseman, Paul W.; Káradóttir, Ragnhildur Þóra; Ruthazer, Edward S. (2021-10-02)
    Myelination allows for the regulation of conduction velocity, affecting the precise timing of neuronal inputs important for the development and function of brain circuits. In turn, myelination may be altered by changes in experience, neuronal activity, ...
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    Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations : an observational study 
    COVIDMENT Collaboration (2022-05)
    BACKGROUND: Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness ...
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    Acute lower gastrointestinal bleeding : A population-based five-year follow-up study 
    Hreinsson, Johann P.; Ægisdottir, Silja; Björnsson, Einar Stefán (2019-12-01)
    Background: Data on the natural history of acute lower gastrointestinal bleeding (ALGIB) are lacking. We evaluated five-year bleeding risk and mortality in ALGIB patients and controls. Furthermore, we aimed to find predictors of rebleeding. Methods: ...
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    Acute type A aortic dissection–a review 
    Gudbjartsson, Tomas; Ahlsson, Anders; Geirsson, Arnar; Gunn, Jarmo; Hjortdal, Vibeke; Jeppsson, Anders; Mennander, Ari; Zindovic, Igor; Olsson, Christian (2020-01-02)
    Acute type A aortic dissection (ATAAD) is still one of the most challenging diseases that cardiac surgeons encounter. This review is based on the current literature and includes the results from the Nordic Consortium for Acute Type-A Aortic Dissection ...
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    Adaptation strategies and neurophysiological response in early-stage Parkinson's disease : BioVRSea approach 
    Jacob, Deborah; Guerrini, Lorena; Pescaglia, Federica; Pierucci, Simona; Gelormini, Carmine; Minutolo, Vincenzo; Fratini, Antonio; Di Lorenzo, Giorgio; Petersen, Hannes; Gargiulo, Paolo (2023)
    INTRODUCTION: There is accumulating evidence that many pathological conditions affecting human balance are consequence of postural control (PC) failure or overstimulation such as in motion sickness. Our research shows the potential of using the response ...
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    The adjuvants dmLT and mmCT enhance humoral immune responses to a pneumococcal conjugate vaccine after both parenteral or mucosal immunization of neonatal mice 
    Molina Estupiñan, Jenny Lorena; Pind, Auður Anna Aradóttir; Pajoohian, Poorya Foroutan; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2023-01-20)
    Immaturity of the neonatal immune system contributes to increased susceptibility to infectious diseases and poor vaccine responses. Therefore, better strategies for early life vaccination are needed. Adjuvants can enhance the magnitude and duration of ...
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    Adults with symptoms of pneumonia : a prospective comparison of patients with and without infiltrates on chest radiography 
    Rögnvaldsson, Kristján Godsk; Bjarnason, Agnar; Ólafsdóttir, Inga Sif; Helgason, Kristján Orri; Guðmundsson, Aðalsteinn; Gottfreðsson, Magnús (2023-01)
    OBJECTIVE: Most studies on patients hospitalized with community-acquired pneumonia (CAP) require confirmation of an infiltrate by chest radiography, but in practice admissions are common among patients with symptoms of pneumonia without an infiltrate ...
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    Adverse childhood experiences and psychological functioning among women with schizophrenia or bipolar disorder : population-based study 
    Köhler-Forsberg, Ole; Ge, Fenfen; Hauksdóttir, Arna; Þórðardóttir, Edda Björk; Ásbjörnsdóttir, Kristjana Hrönn; Rúnarsdóttir, Harpa; Tómasson, Gunnar; Jakobsdóttir, Jóhanna; Guðmundsdóttir, Berglind; Björnsson, Andri Steinþór; Sigurðsson, Engilbert; Aspelund, Thor; Valdimarsdóttir, Unnur Anna (2024-01)
    BACKGROUND: Adverse childhood experiences (ACEs) are well-known risk factors for schizophrenia and bipolar disorder. AIMS: The aim was to study the associations between specific ACEs and psychological functioning in women with schizophrenia or bipolar ...
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    Adverse childhood experiences and resilience among adult women : A population-based study 
    Daníelsdóttir, Hilda Björk; Aspelund, Thor; Thordardottir, Edda Bjork; Fall, Katja; Fang, Fang; Tómasson, Gunnar; Rúnarsdóttir, Harpa; Yang, Qian; Choi, Karmel W; Kennedy, Beatrice; Halldorsdottir, Thorhildur; Lu, Donghao; Song, Huan; Jakobsdóttir, Jóhanna; Hauksdóttir, Arna; Valdimarsdóttir, Unnur Anna (2022-02-01)
    Background: Adverse childhood experiences (ACEs) have consistently been associated with elevated risk of multiple adverse health outcomes, yet their contribution to coping ability and psychiatric resilience in adulthood is unclear. Methods: Cross-sectional ...
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    Adverse health consequences of undiagnosed hearing loss at middle age : A prospective cohort study with the UK Biobank 
    Xu, Shishi; Hou, Can; Han, Xin; Hu, Yao; Yang, Huazhen; Shang, Yanan; Chen, Wenwen; Zeng, Yu; Ying, Zhiye; Sun, Yajing; Qu, Yuanyuan; Lu, Yu; Fang, Fang; Valdimarsdóttir, Unnur A.; Song, Huan (2023-08)
    Objectives: Hearing impairment is common in the middle-aged population but remains largely undiagnosed and untreated. The knowledge about to what extent and how hearing impairment matters for health is currently lacking. Thus, we aimed to comprehensively ...
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    Age differences in functioning and contextual factors in community-dwelling stroke survivors : A national cross-sectional survey 
    Olafsdottir, Steinunn A.; Hjaltadottir, Ingibjörg; Galvin, Rose; Hafsteinsdottir, Thora B.; Jonsdottir, Helga; Arnadottir, Solveig A. (2022-08-25)
    Background Our study aimed to map functioning and contextual factors among community-dwelling stroke survivors after first stroke, based on the International Classification of Functioning, Disability and Health (ICF), and to explore if these factors ...
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    Allele frequency of variants reported to cause adenine phosphoribosyltransferase deficiency 
    Runólfsdóttir, Hrafnhildur L.; Sayer, John A.; Indridason, Olafur S.; Eðvarðsson, Viðar Örn; Jensson, Brynjar O.; Arnadottir, Gudny A.; Gudjonsson, Sigurjon A.; Fridriksdottir, Run; Katrinardottir, Hildigunnur; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari; Pálsson, Runólfur (2021-03-11)
    Adenine phosphoribosyltransferase deficiency is a rare, autosomal recessive disorder of purine metabolism that causes nephrolithiasis and progressive chronic kidney disease. The small number of reported cases indicates an extremely low prevalence, ...
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    ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma 
    Mensali, Nadia; Köksal, Hakan; Joaquina, Sandy; Wernhoff, Patrik; Casey, Nicholas P.; Romecin, Paola; Panisello, Carla; Rodriguez, René; Vimeux, Lene; Juzeniene, Asta; Myhre, Marit R.; Fåne, Anne; Ramírez, Carolina Castilla; Maggadottir, Solrun Melkorka; Duru, Adil Doganay; Georgoudaki, Anna Maria; Grad, Iwona; Maturana, Andrés Daniel; Gaudernack, Gustav; Kvalheim, Gunnar; Carcaboso, Angel M.; de Alava, Enrique; Donnadieu, Emmanuel; Bruland, Øyvind S.; Menendez, Pablo; Inderberg, Else Marit; Wälchli, Sébastien (2023-06-08)
    Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable ...
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    Ambient air pollution and emergency department visits and hospitalisation for cardiac arrest : a population-based case-crossover study in Reykjavik, Iceland 
    Halldorsdottir, Solveig; Finnbjornsdottir, Ragnhildur Gudrun; Elvarsson, Bjarki Thor; Gunnarsdóttir, Oddný Sigurborg; Gudmundsson, Gunnar; Rafnsson, Vilhjálmur (2023-05-15)
    OBJECTIVES: To assess the association between traffic-related ambient air pollution and emergency hospital visits for cardiac arrest. DESIGN: Case-crossover design was used with a lag time to 4 days. SETTING: The Reykjavik capital area and the study ...
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    Ambient nitrogen dioxide is associated with emergency hospital visits for atrial fibrillation : a population-based case-crossover study in Reykjavik, Iceland 
    Halldorsdottir, Solveig; Finnbjornsdottir, Ragnhildur Gudrun; Elvarsson, Bjarki Thor; Guðmundsson, Gunnar; Rafnsson, Vilhjálmur (2022-01-03)
    Background: In Iceland air quality is generally good; however, previous studies indicate that there is an association between air pollution in Reykjavik and adverse health effects as measured by dispensing of medications, mortality, and increase in ...