Browsing by Author "Rolfsson, Ottar"

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Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative Stress

Wang, Qiong; Karvelsson, Sigurdur Trausti; Kotronoulas, Aristotelis; Gudjonsson, Thorarinn; Halldorsson, Skarphedinn; Rolfsson, Ottar (2022-02-01)

Breast cancer cells that have undergone partial epithelial- mesenchymal transition (EMT) are believed to be more invasive than cells that have completed EMT. To study metabolic reprogramming in different mesenchymal states, we analyzed protein expression ...
UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines

Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; de Miranda Fonseca, Davi; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar (2022-05)

Metabolic rewiring is one of the indispensable drivers of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three separately established breast EMT ...

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