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Browsing by Author "Traustadóttir, Gunnhildur Ásta"

Browsing by Author "Traustadóttir, Gunnhildur Ásta"

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  • Miettinen, Juho J.; Kumari, Romika; Traustadóttir, Gunnhildur Ásta; Huppunen, Maiju Emilia; Sergeev, Philipp; Majumder, Muntasir M.; Schepsky, Alexander; Guðjónsson, Þórarinn; Lievonen, Juha; Bazou, Despina; Dowling, Paul; O‘gorman, Peter; Slipicevic, Ana; Anttila, Pekka; Silvennoinen, Raija; Nupponen, Nina N.; Lehmann, Fredrik; Heckman, Caroline A. (2021-03-26)
    Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or ...
  • Schepsky, Alexander; Traustadóttir, Gunnhildur Ásta; Jóelsson, Jón Pétur; Ingþórsson, Sævar; Kricker, Jennifer; Bergthorsson, Jon Thor; Ásbjarnarson, Árni; Gudjonsson, Thorkell; Nupponen, Nina; Slipicevic, Ana; Lehmann, Fredrik; Gudjonsson, Thorarinn (Wiley, 2020-07-27)
    Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...