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Fletta eftir höfundi "Traustadóttir, Gunnhildur Ásta"

Fletta eftir höfundi "Traustadóttir, Gunnhildur Ásta"

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    Aminopeptidase expression in multiple myeloma associates with disease progression and sensitivity to melflufen 
    Miettinen, Juho J.; Kumari, Romika; Traustadóttir, Gunnhildur Ásta; Huppunen, Maiju Emilia; Sergeev, Philipp; Majumder, Muntasir M.; Schepsky, Alexander; Guðjónsson, Þórarinn; Lievonen, Juha; Bazou, Despina; Dowling, Paul; O‘gorman, Peter; Slipicevic, Ana; Anttila, Pekka; Silvennoinen, Raija; Nupponen, Nina N.; Lehmann, Fredrik; Heckman, Caroline A. (2021-03-26)
    Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or ...
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    The BLIMP1—EZH2 nexus in a non-Hodgkin lymphoma 
    Harðardóttir, Ingibjörg; Anderson, Kimberley Jade; Ósvaldsdóttir, Árný Björg; Atzinger, Birgit; Traustadóttir, Gunnhildur Ásta; Jensen, Kirstine Nolling; Lárusdóttir, Aðalheiður Elín; Bergþórsson, Jón Þór; Magnúsdóttir, Erna (2020-07-09)
    Waldenström’s macroglobulinemia (WM) is a non-Hodgkin lymphoma, resulting in antibody-secreting lymphoplasmacytic cells in the bone marrow and pathologies resulting from high levels of monoclonal immunoglobulin M (IgM) in the blood. Despite the key ...
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    Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation 
    Ingþórsson, Sævar; Traustadóttir, Gunnhildur Ásta; Guðjónsson, Þórarinn (2022-10-24)
    The human breast gland is a unique organ as most of its development occurs postnatally between menarche and menopause, a period ranging from 30 to 40 years. During this period, the monthly menstruation cycle drives the mammary gland through phases of ...
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    High Atlastin 2-2 (ATL2-2) Expression Associates with Worse Prognosis in Estrogen-Receptor-Positive Breast Cancer 
    Reynisdóttir, Inga; Arason, Aðalgeir; Freysteinsdóttir, Edda Sigríður; Kristjánsdóttir, Sigrún Bærings; Hilmarsdóttir, Bylgja; Traustadóttir, Gunnhildur Ásta; Jóhannsson, Óskar Þór; Agnarsson, Bjarni Agnar; Barkardóttir, Rósa Björk (2023-08)
    The disruption of endoplasmic reticulum (ER) homeostasis occurs in many human diseases. Atlastins (ATLs) maintain the branched network of the ER. The dysregulation of ATL2, located at ER network junctions, has been associated with cancer. ATL2 is ...
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    Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell lines 
    Schepsky, Alexander; Traustadóttir, Gunnhildur Ásta; Jóelsson, Jón Pétur; Ingþórsson, Sævar; Kricker, Jennifer; Bergthorsson, Jon Thor; Ásbjarnarson, Árni; Gudjonsson, Thorkell; Nupponen, Nina; Slipicevic, Ana; Lehmann, Fredrik; Gudjonsson, Thorarinn (Wiley, 2020-07-27)
    Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...