Opin vísindi

Browsing by Author "Jónasson, Jón Gunnlaugur"

Browsing by Author "Jónasson, Jón Gunnlaugur"

Sort by: Order: Results:

  • Liyanarachchi, Sandya; Gudmundsson, Julius; Ferkingstad, Egil; He, Huiling; Jónasson, Jón Gunnlaugur; Tragante, Vinicius; Asselbergs, Folkert W.; Xu, Li; Kiemeney, Lambertus A.; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hjartarson, Hannes; Hrafnkelsson, Jón; Sturgis, Erich M.; Brock, Pamela; Nabhan, Fadi; Thorleifsson, Gudmar; Ringel, Matthew D.; Stefansson, Kari; de la Chapelle, Albert (2020-03-17)
    Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed ...
  • Stefánsson, Ólafur A.; Hilmarsdóttir, Hólmfridur; Ólafsdóttir, Kristrún; Tryggvadóttir, Laufey; Sverrisdóttir, Ásgerdur; Jóhannsson, Óskar Þór; Jónasson, Jón Gunnlaugur; Eyfjörð, Jórunn Erla; Sigurdsson, Stefán Þórarinn (2019-12-11)
    Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
  • Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L.; Einarsdóttir, Sylvía; Sigurðsson, Ásgeir; Hampel, Heather; Snaebjornsson, Petur; Másson, Gísli; Weng, Daniel; Arngrimsson, Reynir; Kehr, Birte; Yilmaz, Ahmet; Haraldsson, Stefan; sulem, patrick; Stefansson, Tryggvi; Shields, Peter G.; Sigurðsson, Fridbjörn; Bekaii-Saab, Tanios; Moller, Pall H.; Steinarsdóttir, Margrét; Alexíusdóttir, Kristín; Hitchins, Megan; Pritchard, Colin C.; de la Chapelle, Albert; Jónasson, Jón Gunnlaugur; Goldberg, Richard M.; Stefansson, Kari (Springer Nature, 2017-05-03)
    Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch ...
  • Stefansson, Olafur; Hermanowicz, Stefan; van der Horst, Jasper; Hilmarsdóttir, Hólmfríður; Staszczak, Zuzanna; Jónasson, Jón Gunnlaugur; Tryggvadottir, Laufey; Guðjónsson, Þorkell; Sigurðsson, Stefán (Springer Nature, 2017-07-05)
    Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ...
  • Ísberg, Ólöf Gerður; Xiang, Yuchen; Böðvarsdóttir, Sigríður Klara; Jónasson, Jón Gunnlaugur; Þorsteinsdóttir, Margrét; Takats, Zoltan (2021-11)
    Background: Metabolites, especially lipids, have been shown to be promising therapeutic targets. In conjugation with genes and proteins they can be used to identify phenotypes of disease and support the development of targeted treatments. The majority ...
  • Kristjánsson, Haukur; Jónasson, Jón Gunnlaugur; Silverborn, Per Martin; Haraldsdóttir, Sigrí ur Ólína; Guðbjartsson, Tómas (2021-06)
  • Kristjánsson, Haukur; Jónasson, Jón Gunnlaugur; Silverborn, Per Martin; Haraldsdóttir, Sigríður Ólína; Guðbjartsson, Tómas (2021-06)
  • Guðnason, Hafsteinn Óli; Kristinsson, Jón Örvar; Bergmann, Óttar Már; Ólafsson, Sigurður; Jónasson, Jón Gunnlaugur; Björnsson, Einar Stefán (2019-09)
    INNGANGUR Frumkomin trefjunargallgangabólga er langvinnur bólgusjúkdómur í gallvegum innan og/eða utan lifrar sem getur valdið skorpulifur, lokastigs lifrarbilun og leitt til lifrarígræðslu. Bólgusjúkdómar í meltingarvegi, fyrst og fremst sáraristilbólga, ...
  • Ólafsdóttir, Marta; Löve, Arthur; Jónasson, Jón Gunnlaugur; Björnsson, Einar Stefán (2020)
    Lifrarbólga E er veirusjúkdómur sem berst yfirleitt með menguðu vatni og gengur oftast yfir án sértækra inngripa. Hann er algengur á Indlandi og hefur valdið faröldrum, til að mynda í Asíu, Afríku og Mexíkó, en er sjaldséður á Íslandi. Hér er lýst ...
  • Haraldsdóttir, Kristín Huld; Jónasson, Jón Gunnlaugur; Birgisson, Helgi; Sigurðardóttir, Rakel Hekla (2022-09-08)
    INNGANGUR Krabbamein í lifur, gallgangakerfi innan lifrar og gallblöðru ásamt meinvörpum í lifur, eru illvígir sjúkdómar með slæmar horfur. Skurðaðgerð er mikilvægasta meðferðin, sé hún gerð í læknandi tilgangi. Markmið rannsóknarinnar var að kanna ...