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Browsing by Author "Pálsson, Bernhard Örn"

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The quantitative metabolome is shaped by abiotic constraints

Akbari, Amir; Yurkovich, James T.; Zielinski, Daniel C.; Pálsson, Bernhard Örn (2021-05-26)

Living systems formed and evolved under constraints that govern their interactions with the inorganic world. These interactions are definable using basic physico-chemical principles. Here, we formulate a comprehensive set of ten governing abiotic ...
Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications

Anand, Amitesh; Olson, Connor A.; Sastry, Anand V.; Patel, Arjun; Szubin, Richard; Yang, Laurence; Feist, Adam M.; Pálsson, Bernhard Örn (2021-04-06)

Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the pyruvate ...

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