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Fletta eftir höfundi "Mælandsmo, Gunhild M."

Fletta eftir höfundi "Mælandsmo, Gunhild M."

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    Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen 
    Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eiríkur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
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    Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer 
    Pandya, Abhilash D.; Øverbye, Anders; Sahariah, Priyanka; Gaware, Vivek S.; Høgset, Håkon; Másson, Már; Høgset, Anders; Mælandsmo, Gunhild M.; Skotland, Tore; Sandvig, Kirsten; Iversen, Tore-Geir (American Chemical Society (ACS), 2020-02-24)
    In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer ...
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    Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 
    Grinde, Maria T; Hilmarsdóttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads H; Rye, Morten Beck; Mælandsmo, Gunhild M; Moestue, Siver A (2019-05-14)
    INTRODUCTION: Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects ...
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    HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR 
    Ingthorsson, Saevar; Andersen, K; Hilmarsdóttir, Bylgja; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2015-12-21)
    The members of the epidermal growth factor receptor (EGFR) kinase family are important players in breast morphogenesis and cancer. EGFR2/HER2 and EGFR expression have a prognostic value in certain subtypes of breast cancer such as HER2-amplified, ...
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    Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 
    Knutsen, Erik; Das Sajib, Saikat; Fiskaa, Tonje; Lorens, James; Guðjónsson, Þórarinn; Mælandsmo, Gunhild M.; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (2023)
    Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity in the mammary epithelium ...
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    Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells 
    Hilmarsdóttir, Bylgja; Briem, Eiríkur; Halldórsson, Skarphéðinn; Kricker, Jennifer; Ingthorsson, Saevar; Gústafsdóttir, Sigrún; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2017-05-11)
    Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
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    Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 
    Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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    Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy 
    Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit (2021-03-03)
    T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel ...