Opin vísindi

Fletta eftir höfundi "HEBON Investigators"

Fletta eftir höfundi "HEBON Investigators"

Röðun: Raða: Niðurstöður:

  • Icon
    Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores 
    GEMO Study Collaborators; EMBRACE Collaborators; kConFab Investigators; HEBON Investigators; Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (2022-01)
    BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant ...
  • Icon
    Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers 
    GEMO Study Collaborators; EMBRACE Collaborators; SWE-BRCA Investigators; kConFab Investigators; HEBON Investigators (2022-10-06)
    The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 ...
  • Icon
    Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2 
    AOCS Group; CZECANCA Consortium; The Consortium of Investigators of Modifiers of BRCA1/2; Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium; HEBON Investigators; GEMO Study Collaborators (2023-06)
    Background: The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and ...