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Browsing by Author "Sveinbjornsson, Gardar"

Browsing by Author "Sveinbjornsson, Gardar"

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    Age and Influenza-Specific Pre-Vaccination Antibodies Strongly Affect Influenza Vaccine Responses in the Icelandic Population whereas Disease and Medication Have Small Effects 
    Ólafsdóttir, Þórunn Ásta; Alexandersson, Kristján F.; Sveinbjornsson, Gardar; Lapini, Giulia; Palladino, Laura; Montomoli, Emanuele; Del Giudice, Giuseppe; Gudbjartsson, Daniel; Jonsdottir, Ingileif (Frontiers Media SA, 2018-01-08)
    Influenza vaccination remains the best strategy for the prevention of influenza virus-related disease and reduction of disease severity and mortality. However, there is large individual variation in influenza vaccine responses. In this study, we ...
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    Associations of autozygosity with a broad range of human phenotypes 
    Clark, David W; Okada, Yukinori; Moore, Kristjan H S; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L K; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M; Baumbach, Clemens; Biino, Ginevra; Bixley, Matthew J; Brumat, Marco; Chai, Jin-Fang; Corre, Tanguy; Cousminer, Diana L; Dekker, Annelot M; Eccles, David A; van Eijk, Kristel R; Fuchsberger, Christian; Gao, He; Germain, Marine; Gordon, Scott D; de Haan, Hugoline G; Harris, Sarah E; Hofer, Edith; Huerta-Chagoya, Alicia; Igartua, Catherine; Jansen, Iris E; Jia, Yucheng; Kacprowski, Tim; Karlsson, Torgny; Kleber, Marcus E; Li, Shengchao Alfred; Li-Gao, Ruifang; Mahajan, Anubha; Matsuda, Koichi; Meidtner, Karina; Meng, Weihua; Montasser, May E; van der Most, Peter J; Munz, Matthias; Nutile, Teresa; Palviainen, Teemu; Prasad, Gauri; Prasad, Rashmi B; Priyanka, Tallapragada Divya Sri; Rizzi, Federica; Salvi, Erika; Sapkota, Bishwa R; Shriner, Daniel; Skotte, Line; Smart, Melissa C; Smith, Albert Vernon; van der Spek, Ashley; Spracklen, Cassandra N; Strawbridge, Rona J; Tajuddin, Salman M; Trompet, Stella; Turman, Constance; Verweij, Niek; Viberti, Clara; Wang, Lihua; Warren, Helen R; Wootton, Robyn E; Yanek, Lisa R; Yao, Jie; Yousri, Noha A; Zhao, Wei; Adeyemo, Adebowale A; Afaq, Saima; Aguilar-Salinas, Carlos Alberto; Akiyama, Masato; Albert, Matthew L; Allison, Matthew A; Alver, Maris; Aung, Tin; Azizi, Fereidoun; Bentley, Amy R; Boeing, Heiner; Boerwinkle, Eric; Borja, Judith B; de Borst, Gert J; Bottinger, Erwin P; Broer, Linda; Campbell, Harry; Chanock, Stephen; Chee, Miao-Li; Chen, Guanjie; Chen, Yii-Der I; Chen, Zhengming; Chiu, Yen-Feng; Cocca, Massimiliano; Collins, Francis S; Concas, Maria Pina; Corley, Janie; Cugliari, Giovanni; van Dam, Rob M; Damulina, Anna; Daneshpour, Maryam S; Day, Felix R; Delgado, Graciela E; Dhana, Klodian; Doney, Alexander S F; Dörr, Marcus; Doumatey, Ayo P; Dzimiri, Nduna; Ebenesersdóttir, Sigríður Sunna; Elliott, Joshua; Elliott, Paul; Ewert, Ralf; Felix, Janine F; Fischer, Krista; Freedman, Barry I; Girotto, Giorgia; Goel, Anuj; Gögele, Martin; Goodarzi, Mark O; Graff, Mariaelisa; Granot-Hershkovitz, Einat; Grodstein, Francine; Guarrera, Simonetta; Gudbjartsson, Daniel; Guity, Kamran; Gunnarsson, Bjarni; Guo, Yu; Hagenaars, Saskia P; Haiman, Christopher A; Halevy, Avner; Harris, Tamara B; Hedayati, Mehdi; van Heel, David A; Hirata, Makoto; Höfer, Imo; Hsiung, Chao Agnes; Huang, Jinyan; Hung, Yi-Jen; Ikram, M Arfan; Jagadeesan, Anuradha; Jousilahti, Pekka; Kamatani, Yoichiro; Kanai, Masahiro; Kerrison, Nicola D; Kessler, Thorsten; Khaw, Kay-Tee; Khor, Chiea Chuen; de Kleijn, Dominique P V; Koh, Woon-Puay; Kolcic, Ivana; Kraft, Peter; Krämer, Bernhard K; Kutalik, Zoltán; Kuusisto, Johanna; Langenberg, Claudia; Launer, Lenore J; Lawlor, Deborah A; Lee, I-Te; Lee, Wen-Jane; Lerch, Markus M; Li, Liming; Liu, Jianjun; Loh, Marie; London, Stephanie J; Loomis, Stephanie; Lu, Yingchang; Luan, Jian’an; Mägi, Reedik; Manichaikul, Ani W; Manunta, Paolo; Másson, Gísli; Matoba, Nana; Mei, Xue W; Meisinger, Christa; Meitinger, Thomas; Mezzavilla, Massimo; Milani, Lili; Millwood, Iona Y; Momozawa, Yukihide; Moore, Amy; Morange, Pierre-Emmanuel; Moreno-Macías, Hortensia; Mori, Trevor A; Morrison, Alanna C; Muka, Taulant; Murakami, Yoshinori; Murray, Alison D; de Mutsert, Renée; Mychaleckyj, Josyf C; Nalls, Mike A; Nauck, Matthias; Neville, Matt J; Nolte, Ilja M; Ong, Ken K; Orozco, Lorena; Padmanabhan, Sandosh; Pálsson, Gunnar; Pankow, James S; Pattaro, Cristian; Pattie, Alison; Polasek, Ozren; Poulter, Neil; Pramstaller, Peter P; Quintana-Murci, Lluis; Räikkönen, Katri; Ralhan, Sarju; Rao, Dabeeru C; van Rheenen, Wouter; Rich, Stephen S; Ridker, Paul M; Rietveld, Cornelius A; Robino, Antonietta; van Rooij, Frank J A; Ruggiero, Daniela; Saba, Yasaman; Sabanayagam, Charumathi; Sabater-Lleal, Maria; Sala, Cinzia Felicita; Salomaa, Veikko; Sandow, Kevin; Schmidt, Helena; Scott, Laura J; Scott, William R; Sedaghati-Khayat, Bahareh; Sennblad, Bengt; van Setten, Jessica; Sever, Peter J; Sheu, Wayne H-H; Shi, Yuan; Shrestha, Smeeta; Shukla, Sharvari Rahul; Sigurðsson, Jón K.; Sikka, Timo Tonis; Singh, Jai Rup; Smith, Blair H.; Stančáková, Alena; Stanton, Alice; Starr, John M; Stefánsdóttir, Lilja; Straker, Leon; sulem, patrick; Sveinbjornsson, Gardar; Swertz, Morris A; Taylor, Adele M; Taylor, Kent D; Terzikhan, Natalie; Tham, Yih-Chung; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tillander, Annika; Tracy, Russell P; Tusié-Luna, Teresa; Tzoulaki, Ioanna; Vaccargiu, Simona; Vangipurapu, Jagadish; Veldink, Jan H; Vitart, Veronique; Völker, Uwe; Vuoksimaa, Eero; Wakil, Salma M; Waldenberger, Melanie; Wander, Gurpreet S; Wang, Ya Xing; Wareham, Nicholas J; Wild, Sarah; Yajnik, Chittaranjan S; Yuan, Jian-Min; Zeng, Lingyao; Zhang, Liang; Zhou, Jie; Amin, Najaf; Asselbergs, Folkert W; Bakker, Stephan J L; Becker, Diane M; Lehne, Benjamin; Bennett, David A; van den Berg, Leonard H; Berndt, Sonja I; Bharadwaj, Dwaipayan; Bielak, Lawrence F; Bochud, Murielle; Boehnke, Mike; Bouchard, Claude; Bradfield, Jonathan P; Brody, Jennifer A; Campbell, Archie; Carmi, Shai; Caulfield, Mark J; Cesarini, David; Chambers, John C; Chandak, Giriraj Ratan; Cheng, Ching-Yu; Ciullo, Marina; Cornelis, Marilyn; Cusi, Daniele; Smith, George Davey; Deary, Ian J; Dorajoo, Rajkumar; van Duijn, Cornelia M; Ellinghaus, David; Erdmann, Jeanette; Eriksson, Johan G; Evangelou, Evangelos; Evans, Michele K; Faul, Jessica D; Feenstra, Bjarke; Feitosa, Mary; Foisy, Sylvain; Franke, Andre; Friedlander, Yechiel; Gasparini, Paolo; Gieger, Christian; Gonzalez, Clicerio; Goyette, Philippe; Grant, Struan F A; Griffiths, Lyn R; Groop, Leif; Gudnason, Vilmundur; Gyllensten, Ulf; Hakonarson, Hakon; Hamsten, Anders; van der Harst, Pim; Heng, Chew-Kiat; Hicks, Andrew A; Hochner, Hagit; Huikuri, Heikki; Hunt, Steven C; Jaddoe, Vincent W V; De Jager, Philip L; Johannesson, Magnus; Johansson, Åsa; Jonas, Jost B; Jukema, J. Wouter; Junttila, Juhani; Kaprio, Jaakko; Kardia, Sharon L. R.; Karpe, Fredrik; Kumari, Meena; Laakso, Markku; van der Laan, Sander W; Lahti, Jari; Laudes, Matthias; Lea, Rodney A; Lieb, Wolfgang; Lumley, Thomas; Martin, Nicholas G; März, Winfried; Matullo, Giuseppe; McCarthy, Mark I; Medland, Sarah E; Merriman, Tony R; Metspalu, Andres; Meyer, Brian F; Mohlke, Karen L; Montgomery, Grant W; Mook-Kanamori, Dennis; Munroe, Patricia B; North, Kari E; Nyholt, Dale R; O’connell, Jeffery R; Ober, Carole; Oldehinkel, Albertine J; Palmas, Walter; Palmer, Colin; Pasterkamp, Gerard G; Patin, Etienne; Pennell, Craig E; Perusse, Louis; Peyser, Patricia A; Pirastu, Mario; Polderman, Tinca J. C.; Porteous, David J; Posthuma, Danielle; Psaty, Bruce M; Rioux, John D; Rivadeneira, Fernando; Rotimi, Charles; Rotter, Jerome I; Rudan, Igor; Den Ruijter, Hester M; Sanghera, Dharambir K; Sattar, Naveed; Schmidt, Reinhold; Schulze, Matthias B; Schunkert, Heribert; Scott, Robert A; Shuldiner, Alan R; Sim, Xueling; Small, Neil; Smith, Jennifer A; Sotoodehnia, Nona; Tai, E-Shyong; Teumer, Alexander; Timpson, Nicholas J; Toniolo, Daniela; Tregouet, David-Alexandre; Tuomi, Tiinamaija; Vollenweider, Peter; Wang, Carol A; Weir, David R; Whitfield, John B; Wijmenga, Cisca; Wong, Tien-Yin; Wright, John; Yang, Jingyun; Yu, Lei; Zemel, Babette S; Zonderman, Alan B; Perola, Markus; Magnusson, Patrik K. E.; Uitterlinden, André G; Kooner, Jaspal S; Chasman, Daniel I; Loos, Ruth J. F.; Franceschini, Nora; Franke, Lude; Haley, Chris S; Hayward, Caroline; Walters, Robin G; Perry, John R. B.; Esko, Tōnu; Helgason, Agnar; Stefansson, Kari; Joshi, Peter K; Kubo, Michiaki; Wilson, James F (Springer Science and Business Media LLC, 2019-10-31)
    In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is ...
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    Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 
    Prins, Bram P.; Mead, Timothy J.; Brody, Jennifer A.; Sveinbjornsson, Gardar; Ntalla, Ioanna; Bihlmeyer, Nathan A.; van den Berg, Marten; Bork-Jensen, Jette; Cappellani, Stefania; Van Duijvenboden, Stefan; Klena, Nikolai T.; Gabriel, George C.; Liu, Xiaoqin; Gulec, Cagri; Grarup, Niels; Haessler, Jeffrey; Hall, Leanne M.; Iorio, Annamaria; Isaacs, Aaron; Li-Gao, Ruifang; Lin, Honghuang; Liu, Ching-Ti; Lyytikäinen, Leo-Pekka; Marten, Jonathan; Mei, Hao; Müller-Nurasyid, Martina; Orini, Michele; Padmanabhan, Sandosh; Radmanesh, Farid; Ramirez, Julia; Robino, Antonietta; Schwartz, Molly; van Setten, Jessica; Smith, Albert Vernon; Verweij, Niek; Warren, Helen R.; Weiss, Stefan; Alonso, Alvaro; Arnar, Davíð O.; Bots, Michiel L.; de Boer, Rudolf A.; Dominiczak, Anna F.; Eijgelsheim, Mark; Ellinor, Patrick T.; Guo, Xiuqing; Felix, Stephan B.; Harris, Tamara B.; Hayward, Caroline; Heckbert, Susan R.; Huang, Paul L.; Jukema, J. Wouter; Kähönen, Mika; Kors, Jan A.; Lambiase, Pier D.; Launer, Lenore J.; Li, Man; Linneberg, Allan; Nelson, Christopher P.; Pedersen, Oluf; Perez, Marco; Peters, Annette; Polasek, Ozren; Psaty, Bruce M.; Raitakari, Olli T.; Rice, Kenneth M.; Rotter, Jerome I.; Sinner, Moritz F.; Soliman, Elsayed Z.; Spector, Tim D.; Strauch, Konstantin; Thorsteinsdottir, Unnur; Tinker, Andrew; Trompet, Stella; Uitterlinden, André; Vaartjes, Ilonca; van der Meer, Peter; Völker, Uwe; Völzke, Henry; Waldenberger, Melanie; Wilson, James G.; Xie, Zhijun; Asselbergs, Folkert W.; Dörr, Marcus; van Duijn, Cornelia M.; Gasparini, Paolo; Gudbjartsson, Daniel; Gudnason, Vilmundur; Hansen, Torben; Kääb, Stefan; Kanters, Jørgen K.; Kooperberg, Charles; Lehtimäki, Terho; Lin, Henry J.; Lubitz, Steven A.; Mook-Kanamori, Dennis O.; Conti, Francesco J.; Newton-Cheh, Christopher H.; Rosand, Jonathan; Rudan, Igor; Samani, Nilesh J.; Sinagra, Gianfranco; Smith, Blair H.; Holm, Hilma; Stricker, Bruno H.; Ulivi, Sheila; Sotoodehnia, Nona; Apte, Suneel S.; van der Harst, Pim; Stefansson, Kari; Munroe, Patricia B.; Arking, Dan E.; Lo, Cecilia W.; Jamshidi, Yalda (Springer Science and Business Media LLC, 2018-07-17)
    Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants ...
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    Genetic architecture of band neutrophil fraction in Iceland 
    Oskarsson, Gudjon R.; Magnusson, Magnus K.; Oddsson, Asmundur; Jensson, Brynjar O.; Fridriksdottir, Run; Arnadottir, Gudny A.; Katrinardottir, Hildigunnur; Rognvaldsson, Solvi; Halldorsson, Gisli H.; Sveinbjornsson, Gardar; Ivarsdottir, Erna V.; Stefansdottir, Lilja; Ferkingstad, Egil; Norland, Kristjan; Tragante, Vinicius; Saemundsdottir, Jona; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Sigurjonsdottir, Svanhvit; Petursdottir, Karen O.; Davidsson, Olafur B.; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Onundarson, Pall T.; Vidarsson, Brynjar; Sigurdardottir, Olof; Masson, Gisli; Gudbjartsson, Daniel F.; Jonsdottir, Ingileif; Norddahl, Gudmundur L.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari (2022-06-01)
    The characteristic lobulated nuclear morphology of granulocytes is partially determined by composition of nuclear envelope proteins. Abnormal nuclear morphology is primarily observed as an increased number of hypolobulated immature neutrophils, called ...
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    Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease 
    Helgadottir, Anna; Thorleifsson, Gudmar; Alexandersson, Kristjan F; Tragante, Vinicius; Þorsteinsdóttir, Margrét; Eiriksson, Finnur Freyr; Grétarsdóttir, Sólveig; Björnsson, Eyþór; Magnússon, Ólafur; Sveinbjornsson, Gardar; Jonsdottir, Ingileif; Steinthorsdottir, Valgerdur; Ferkingstad, Egil; Jensson, Brynjar Ö; Stefansson, Hreinn; Olafsson, Isleifur; Christensen, Alex H; Torp-Pedersen, Christian; Køber, Lars; Pedersen, Ole B; Erikstrup, Christian; Sørensen, Erik; Brunak, Søren; Banasik, Karina; Hansen, Thomas F; Nyegaard, Mette; Eyjólfsson, Guðmundur I.; Sigurdardottir, Olof; Þórarinsson, Björn L; Matthíasson, Stefán E.; Steingrimsdottir, Thora; Björnsson, Einar Stefán; Danielsen, Ragnar; Asselbergs, Folkert W.; Arnar, David O; Ullum, Henrik; Bundgaard, Henning; sulem, patrick; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Holm, Hilma; Gudbjartsson, Daniel; Stefansson, Kari (Oxford University Press (OUP), 2020-07-21)
    Aims: To explore whether variability in dietary cholesterol and phytosterol absorption impacts the risk of coronary artery disease (CAD) using as instruments sequence variants in the ABCG5/8 genes, key regulators of intestinal absorption of dietary ...
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    Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria 
    Teumer, Alexander; Li, Yong; Ghasemi, Sahar; Prins, Bram P.; Wuttke, Matthias; Hermle, Tobias; Giri, Ayush; Sieber, Karsten B.; Qiu, Chengxiang; Kirsten, Holger; Tin, Adrienne; Chu, Audrey Y.; Bansal, Nisha; Feitosa, Mary F.; Wang, Lihua; Chai, Jin-Fang; Cocca, Massimiliano; Fuchsberger, Christian; Gorski, Mathias; Hoppmann, Anselm; Horn, Katrin; Li, Man; Marten, Jonathan; Noce, Damia; Nutile, Teresa; Sedaghat, Sanaz; Sveinbjornsson, Gardar; Tayo, Bamidele O.; van der Most, Peter J.; Xu, Yizhe; Yu, Zhi; Gerstner, Lea; Ärnlöv, Johan; Bakker, Stephan J. L.; Baptista, Daniela; Biggs, Mary L.; Boerwinkle, Eric; Brenner, Hermann; Burkhardt, Ralph; Carroll, Robert J.; Chee, Miao-Li; Chee, Miao-Ling; Chen, Mengmeng; Cheng, Ching-Yu; Cook, James P.; Coresh, Josef; Corre, Tanguy; Danesh, John; de Borst, Martin H.; De Grandi, Alessandro; de Mutsert, Renée; de Vries, Aiko P. J.; Degenhardt, Frauke; Dittrich, Katalin; Divers, Jasmin; Eckardt, Kai-Uwe; Ehret, Georg; Endlich, Karlhans; Felix, Janine F.; Franco, Oscar H.; Franke, Andre; Freedman, Barry I.; Freitag-Wolf, Sandra; Gansevoort, Ron T.; Giedraitis, Vilmantas; Gögele, Martin; Grundner-Culemann, Franziska; Gudbjartsson, Daniel; Gudnason, Vilmundur; Hamet, Pavel; Harris, Tamara B.; Hicks, Andrew A.; Holm, Hilma; Foo, Valencia Hui Xian; Hwang, Shih-Jen; Ikram, M. Arfan; Ingelsson, Erik; Jaddoe, Vincent W. V.; Jakobsdottir, Johanna; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Khor, Chiea-Chuen; Kiess, Wieland; Koenig, Wolfgang; Körner, Antje; Kovacs, Peter; Kramer, Holly; Krämer, Bernhard K.; Kronenberg, Florian; Lange, Leslie A.; Langefeld, Carl D.; Lee, Jeannette Jen-Mai; Lehtimäki, Terho; Lieb, Wolfgang; Lim, Su-Chi; Lind, Lars; Lindgren, Cecilia M.; Liu, Jianjun; Loeffler, Markus; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Maranville, Joseph C.; Mascalzoni, Deborah; McMullen, Barbara; Meisinger, Christa; Meitinger, Thomas; Miliku, Kozeta; Mook-Kanamori, Dennis O.; Müller-Nurasyid, Martina; Mychaleckyj, Josyf C.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Noordam, Raymond; Connell, Jeffrey O’; Olafsson, Isleifur; Palmer, Nicholette D.; Peters, Annette; Podgornaia, Anna I.; Ponte, Belen; Poulain, Tanja; Pramstaller, Peter P.; Rabelink, Ton J.; Raffield, Laura M.; Reilly, Dermot F.; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth M.; Rivadeneira, Fernando; Runz, Heiko; Ryan, Kathleen A.; Sabanayagam, Charumathi; Saum, Kai-Uwe; Schöttker, Ben; Shaffer, Christian M.; Shi, Yuan; Smith, Albert Vernon; Strauch, Konstantin; Stumvoll, Michael; Sun, Benjamin B.; Szymczak, Silke; Tai, E-Shyong; Tan, Nicholas Y. Q.; Taylor, Kent D.; Teren, Andrej; Tham, Yih-Chung; Thiery, Joachim; Thio, Chris H. L.; Thomsen, Hauke; Thorsteinsdottir, Unnur; Tönjes, Anke; Tremblay, Johanne; Uitterlinden, André G.; van der Harst, Pim; Verweij, Niek; Vogelezang, Suzanne; Völker, Uwe; Waldenberger, Melanie; Wang, Chaolong; Wilson, Otis D.; Wong, Charlene; Wong, Tien-Yin; Yang, Qiong; Yasuda, Masayuki; Akilesh, Shreeram; Bochud, Murielle; Böger, Carsten A.; Devuyst, Olivier; Edwards, Todd L.; Ho, Kevin; Morris, Andrew P.; Parsa, Afshin; Pendergrass, Sarah A.; Psaty, Bruce M.; Rotter, Jerome I.; Stefansson, Kari; Wilson, James G.; Susztak, Katalin; Snieder, Harold; Heid, Iris M.; Scholz, Markus; Butterworth, Adam S.; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna (Springer Science and Business Media LLC, 2019-09-11)
    Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) ...
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    Genome-wide association meta-analysis yields 20 loci associated with gallstone disease 
    Ferkingstad, Egil; Oddsson, Asmundur; Gretarsdottir, Solveig; Benonisdottir, Stefania; Thorleifsson, Gudmar; Deaton, Aimee M.; Jónsson, Stefán; Stefánsson, Ólafur A.; Norðdahl, Guðmundur L.; Zink, Florian; Arnadottir, Gudny; Gunnarsson, Bjarni; Halldorsson, Gisli; Helgadottir, Anna; Jensson, Brynjar Örn; Kristjánsson, Ragnar P.; Sveinbjornsson, Gardar; Sverrisson, Davíð A.; Másson, Gísli; Olafsson, Isleifur; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Holm, Hilma; Jonsdottir, Ingileif; Ólafsson, Sigurður; Steingrimsdottir, Thora; Rafnar, Thorunn; Björnsson, Einar Stefán; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2018-11-30)
    Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genomewide association studies of gallstone disease in Iceland and the UK, totaling ...
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    MAP1B mutations cause intellectual disability and extensive white matter deficit 
    Walters, G. Bragi; Gústafsson, Ómar; Sveinbjornsson, Gardar; Eiriksdottir, Valgerdur Kristin; Ágústsdóttir, Arna B.; Jónsdóttir, Guðrún A.; Steinberg, Stacy; Gunnarsson, Árni F.; Magnússon, Magnús I.; Unnsteinsdóttir, Unnur; Lee, Amy L.; Jónasdóttir, Aðalbjörg; Sigurðsson, Ásgeir; Jónasdóttir, Áslaug; Skúladóttir, Ástrós; Jonsson, Lina; Nawaz, Muhammad S.; sulem, patrick; Frigge, Mike; Ingason, Andrés; Love, Askell; Norðdahl, Guðmundur L.; Zervas, Mark; Gudbjartsson, Daniel; Ulfarsson, Magnus; Sæmundsen, Evald E.; Stefansson, Hreinn; Stefansson, Kari (Springer Science and Business Media LLC, 2018-08-27)
    Discovery of coding variants in genes that confer risk of neurodevelopmental disorders is an important step towards understanding the pathophysiology of these disorders. Wholegenome sequencing of 31,463 Icelanders uncovers a frameshift variant ...
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    A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy 
    Skuladottir, Astros Th; Bjornsdottir, Gyda; Thorleifsson, Gudmar; Walters, G. Bragi; Nawaz, Muhammad Sulaman; Moore, Kristjan Helgi Swerford; Olason, Pall I.; Thorgeirsson, Thorgeir E.; Sigurpalsdottir, Brynja; Sveinbjornsson, Gardar; Eggertsson, Hannes P.; Magnusson, Sigurdur H.; Oddsson, Asmundur; Bjornsdottir, Anna; Vikingsson, Arnor; Sveinsson, Olafur A.; Hrafnsdottir, Maria G.; Sigurdardottir, Gudrun R.; Halldorsson, Bjarni V.; Hansen, Thomas Folkmann; Paarup, Helene; Erikstrup, Christian; Nielsen, Kaspar; Klokker, Mads; Bruun, Mie Topholm; Sorensen, Erik; Banasik, Karina; Burgdorf, Kristoffer S.; Pedersen, Ole Birger; Ullum, Henrik; Jonsdottir, Ingileif; Stefansson, Hreinn; Stefansson, Kari (2021-02-18)
    Bell’s palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have ...
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    Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction 
    Ntalla, Ioanna; Weng, Lu-Chen; Cartwright, James H.; Hall, Amelia Weber; Sveinbjornsson, Gardar; Tucker, Nathan R.; Choi, Seung Hoan; Chaffin, Mark D.; Roselli, Carolina; Barnes, Michael R.; Mifsud, Borbala; Warren, Helen R.; Hayward, Caroline; Marten, Jonathan; Cranley, James J.; Concas, Maria Pina; Gasparini, Paolo; Boutin, Thibaud; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Araujo, Nathalia M.; Lima-Costa, Maria Fernanda; Ribeiro, Antonio Luiz P.; Souza, Renan P.; Tarazona-Santos, Eduardo; Giedraitis, Vilmantas; Ingelsson, Erik; Mahajan, Anubha; Morris, Andrew P.; Del Greco M, Fabiola; Foco, Luisa; Gögele, Martin; Hicks, Andrew A.; Cook, James P.; Lind, Lars; Lindgren, Cecilia M.; Sundström, Johan; Nelson, Christopher P.; Riaz, Muhammad B.; Samani, Nilesh J.; Sinagra, Gianfranco; Ulivi, Sheila; Kähönen, Mika; Mishra, Pashupati P.; Mononen, Nina; Nikus, Kjell; Caulfield, Mark J.; Dominiczak, Anna; Padmanabhan, Sandosh; Montasser, May E.; O’Connell, Jeff R.; Ryan, Kathleen; Shuldiner, Alan R.; Aeschbacher, Stefanie; Conen, David; Risch, Lorenz; Thériault, Sébastien; Hutri-Kähönen, Nina; Lehtimäki, Terho; Lyytikäinen, Leo-Pekka; Raitakari, Olli T.; Barnes, Catriona L. K.; Campbell, Harry; Joshi, Peter K.; Wilson, James F.; Isaacs, Aaron; Kors, Jan A.; van Duijn, Cornelia M.; Huang, Paul L.; Gudnason, Vilmundur; Harris, Tamara B.; Launer, Lenore J.; Smith, Albert Vernon; Bottinger, Erwin P.; Loos, Ruth J. F.; Nadkarni, Girish N.; Preuss, Michael H.; Correa, Adolfo; Mei, Hao; Wilson, James; Meitinger, Thomas; Müller-Nurasyid, Martina; Peters, Annette; Waldenberger, Melanie; Mangino, Massimo; Spector, Timothy D.; Rienstra, Michiel; van de Vegte, Yordi J.; van der Harst, Pim; Verweij, Niek; Kääb, Stefan; Schramm, Katharina; Sinner, Moritz F.; Strauch, Konstantin; Cutler, Michael J.; Fatkin, Diane; London, Barry; Olesen, Morten; Roden, Dan M.; Benjamin Shoemaker, M.; Gustav Smith, J.; Biggs, Mary L.; Bis, Joshua C.; Brody, Jennifer A.; Psaty, Bruce M.; Rice, Kenneth; Sotoodehnia, Nona; De Grandi, Alessandro; Fuchsberger, Christian; Pattaro, Cristian; Pramstaller, Peter P.; Ford, Ian; Wouter Jukema, J.; Macfarlane, Peter W.; Trompet, Stella; Dörr, Marcus; Felix, Stephan B.; Völker, Uwe; Weiss, Stefan; Havulinna, Aki S.; Jula, Antti; Sääksjärvi, Katri; Salomaa, Veikko; Guo, Xiuqing; Heckbert, Susan R.; Lin, Henry J.; Rotter, Jerome I.; Taylor, Kent D.; Yao, Jie; de Mutsert, Renée; Maan, Arie C.; Mook-Kanamori, Dennis O.; Noordam, Raymond; Cucca, Francesco; Ding, Jun; Lakatta, Edward G.; Qian, Yong; Tarasov, Kirill V.; Levy, Daniel; Lin, Honghuang; Newton-Cheh, Christopher H.; Lunetta, Kathryn L.; Murray, Alison D.; Porteous, David J.; Smith, Blair H.; Stricker, Bruno H.; Uitterlinden, André; van den Berg, Marten E.; Haessler, Jeffrey; Jackson, Rebecca D.; Kooperberg, Charles; Peters, Ulrike; Reiner, Alexander P.; Whitsel, Eric A.; Alonso, Alvaro; Arking, Dan E.; Boerwinkle, Eric; Ehret, Georg B.; Soliman, Elsayed Z.; Avery, Christy L.; Gogarten, Stephanie M.; Kerr, Kathleen F.; Laurie, Cathy C.; Seyerle, Amanda A.; Stilp, Adrienne; Assa, Solmaz; Abdullah Said, M.; Yldau van der Ende, M.; Lambiase, Pier D.; Orini, Michele; Ramirez, Julia; Van Duijvenboden, Stefan; Arnar, Davíð O.; Gudbjartsson, Daniel; Holm, Hilma; sulem, patrick; Thorleifsson, Gudmar; Thorolfsdottir, Rosa B; Thorsteinsdottir, Unnur; Benjamin, Emelia J.; Tinker, Andrew; Stefansson, Kari; Ellinor, Patrick T.; Jamshidi, Yalda; Lubitz, Steven A.; Munroe, Patricia B. (Springer Science and Business Media LLC, 2020-05-21)
    The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) ...
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    Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis 
    Óskarsson, Guðjón R.; Oddsson, Asmundur; Magnusson, Magnus Karl; Kristjansson, Ragnar; Halldorsson, Gisli; Ferkingstad, Egil; Zink, Florian; Helgadottir, Anna; Ívarsdóttir, Erna V.; Arnadottir, Gudny; Jensson, Brynjar Örn; Katrinardottir, Hildigunnur; Sveinbjornsson, Gardar; Kristinsdóttir, Anna Margrét; Lee, Amy L.; Sæmundsdóttir, Jóna; Stefánsdóttir, Lilja; Sigurðsson, Jón K.; Davíðsson, Ólafur B.; Benonisdottir, Stefania; Jónasdóttir, Áslaug; Jónasdóttir, Aðalbjörg; Jonsson, Stefan; Guðmundsson, Reynir L.; Asselbergs, Folkert W.; Tragante, Vinicius; Gunnarsson, Bjarni; Másson, Gísli; Thorleifsson, Gudmar; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Önundarson, Páll Torfi; Gudbjartsson, Daniel; Norðdahl, Guðmundur L.; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2020-04-23)
    Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and oxygen sensing mechanisms. To search for novel variants associated with hemoglobin concentration, we performed genome-wide association studies of ...
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    Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis 
    Oskarsson, Gudjon R.; Oddsson, Asmundur; Magnusson, Magnus K.; Kristjansson, Ragnar P.; Halldorsson, Gisli H.; Ferkingstad, Egil; Zink, Florian; Helgadottir, Anna; Ivarsdottir, Erna V.; Arnadottir, Gudny A.; Jensson, Brynjar O.; Katrinardottir, Hildigunnur; Sveinbjornsson, Gardar; Kristinsdottir, Anna M.; Lee, Amy L.; Saemundsdottir, Jona; Stefansdottir, Lilja; Sigurdsson, Jon K.; Davidsson, Olafur B.; Benonisdottir, Stefania; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Jonsson, Stefan; Gudmundsson, Reynir L.; Asselbergs, Folkert W.; Tragante, Vinicius; Gunnarsson, Bjarni; Masson, Gisli; Thorleifsson, Gudmar; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Onundarson, Pall T.; Gudbjartsson, Daniel F.; Norddahl, Gudmundur L.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari (2020-04-23)
    Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and oxygen sensing mechanisms. To search for novel variants associated with hemoglobin concentration, we performed genome-wide association studies of ...
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    A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma 
    Smith, Dirk; Helgason, Hannes; sulem, patrick; Björnsdóttir, Unnur Steina; Lim, Ai Ching; Sveinbjornsson, Gardar; Hasegawa, Haruki; Brown, Michael; Ketchem, Randal R.; Gavala, Monica; Garrett, Logan; Jónasdóttir, Aðalbjörg; Jónasdóttir, Áslaug; Sigurðsson, Ásgeir; Magnússon, Ólafur T.; Eyjólfsson, Guðmundur I.; Ólafsson, Ísleifur; Önundarson, Páll Torfi; Sigurðardóttir, Ólöf; Gíslason, Davíð; Gislason, Thorarinn; Ludviksson, Bjorn; Lúðvíksdóttir, Dóra; Boezen, H. Marike; Heinzmann, Andrea; Krueger, Marcus; Porsbjerg, Celeste; Ahluwalia, Tarunveer S.; Waage, Johannes; Backer, Vibeke; Deichmann, Klaus A.; Koppelman, Gerard H.; Bønnelykke, Klaus; Bisgaard, Hans; Másson, Gísli; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Johnston, James A.; Jonsdottir, Ingileif; Stefansson, Kari (Public Library of Science (PLoS), 2017-03-08)
    IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with ...
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    A rare missense mutation in MYH6 associates with non-syndromic coarctation of the aorta 
    Björnsson, Þorsteinn; Þórólfsdóttir, Rósa B.; Sveinbjornsson, Gardar; sulem, patrick; Norðdahl, Guðmundur L.; Helgadóttir, Anna; Grétarsdóttir, Sólveig; Magnusdóttir, Auður; Danielsen, Ragnar; Sigurðsson, Emil Lárus; Adalsteinsdottir, Berglind; Gunnarsson, Sverrir I; Jonsdottir, Ingileif; Arnar, Davíð O.; Helgason, Hróðmar; Gudbjartsson, Tomas; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Holm, Hilma; Stefansson, Kari (Oxford University Press (OUP), 2018-03-24)
    Aims Coarctation of the aorta (CoA) accounts for 4-8% of congenital heart defects (CHDs) and confers substantial morbidity despite treatment. It is increasingly recognized as a highly heritable condition. The aim of the study was to search for sequence ...
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    Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation 
    Bjornsdottir, Gyda; Benonisdottir, Stefania; Sveinbjornsson, Gardar; Styrkarsdottir, Unnur; Þorleifsson, Guðmar; Walters, G. Bragi; Björnsson, Aron; Ólafsson, Ingvar Hákon; Úlfarsson, Elfar; Víkingsson, Arnór; Hansdóttir, Ragnheiður; Karlsson, Karl O.; Rafnar, Thorunn; Jonsdottir, Ingileif; Frigge, Michael L.; Kong, Augustine; Oddsson, Asmundur; Másson, Gísli; Magnússon, Ólafur T.; Gudbjartsson, Tomas; Stefánsson, Hreinn; sulem, patrick; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Thorgeirsson, Thorgeir; Stefansson, Kari (Springer Nature, 2017-02-22)
    Lumbar disc herniation (LDH) is common and often debilitating. Microdiscectomy of herniated lumbar discs (LDHsurg) is performed on the most severe cases to resolve the resulting sciatica. Here we perform a genome-wide association study on 4,748 LDHsurg ...
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    Sequence variants associating with urinary biomarkers 
    Benonisdottir, Stefania; Kristjansson, Ragnar P; Oddsson, Asmundur; Steinthorsdottir, Valgerdur; Mikaelsdottir, Evgenia; Kehr, Birte; Jensson, Brynjar O; Arnadottir, Gudny A; Sulem, Gerald; Sveinbjornsson, Gardar; Kristmundsdóttir, Snædís; Ívarsdóttir, Erna V.; Tragante, Vinicius; Gunnarsson, Bjarni; Runolfsdottir, Hrafnhildur Linnet; Arthur, Joseph G; Deaton, Aimee M; Eyjolfsson, Gudmundur I; Davidsson, Olafur B; Asselbergs, Folkert W; Hreidarsson, Astradur B; Rafnar, Thorunn; Thorleifsson, Gudmar; Edvardsson, Vidar; Sigurdsson, Gunnar; Helgadottir, Anna; Halldórsson, Bjarni; Masson, Gisli; Holm, Hilma; Önundarson, Páll Torfi; Indridason, Olafur S; Benediktsson, Rafn; Palsson, Runolfur; Gudbjartsson, Daniel F; Olafsson, Isleifur; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Oxford University Press (OUP), 2018-11-24)
    Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental factors are known to affect the test results, whereas the effects of genetic diversity are largely unknown. ...
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    Sequence variants with large effects on cardiac electrophysiology and disease 
    Norland, Kristján; Sveinbjornsson, Gardar; Thorolfsdottir, Rosa B; Davidsson, Olafur B.; Tragante, Vinicius; Rajamani, Sridharan; Helgadottir, Anna; Grétarsdóttir, Sólveig; van Setten, Jessica; Asselbergs, Folkert W.; Sverrisson, Jon Th.; Stephensen, Sigurdur Sverrir; Óskarsson, Gylfi; Sigurðsson, Emil Lárus; Andersen, Karl; Danielsen, Ragnar; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Arnar, Davíð O.; sulem, patrick; Holm, Hilma; Gudbjartsson, Daniel; Stefansson, Kari (Springer Science and Business Media LLC, 2019-10-22)
    Features of the QRS complex of the electrocardiogram, reflecting ventricular depolarisation, associate with various physiologic functions and several pathologic conditions. We test 32.5 million variants for association with ten measures of the QRS ...
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    Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits 
    Rafnar, Thorunn; Bjarni Gunnarsson; Ólafur A. Stefánsson; sulem, patrick; Ingason, Andrés; Frigge, Michael L.; Lilja Stefánsdóttir; Jón K. Sigurðsson; Tragante, Vinicius; Steinthorsdottir, Valgerdur; Styrkarsdottir, Unnur; Stacey, Simon N.; Gudmundsson, Julius; Arnadottir, Gudny; Oddsson, Asmundur; Zink, Florian; Halldorsson, Gisli; Sveinbjornsson, Gardar; Kristjansson, Ragnar; Ólafur B. Davíðsson; Anna Þórhildur Salvarsdóttir; Ásgeir Thoroddsen; Elísabet A. Helgadottir; Katrín Kristjánsdóttir; Orri Ingþórsson; Valur Guðmundsson; Geirsson, Reynir T.; Ragnheiður Árnadottir; Gudbjartsson, Daniel; Másson, Gísli; Asselbergs, Folkert W.; Jón Gunnlaugur Jónasson; Karl Ólafsson; Thorsteinsdottir, Unnur; Halldórsson, Bjarni; Thorleifsson, Gudmar; Stefansson, Kari (Springer Science and Business Media LLC, 2018-09-07)
    Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with ...