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Browsing by Author "Kricker, Jennifer"

Browsing by Author "Kricker, Jennifer"

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  • Jóelsson, Jón Pétur; Kricker, Jennifer; Arason, Ari Jon; Sigurdsson, Snaevar; Valdimarsdóttir, Bryndís; Garðarsson, Friðrik Rúnar; Page, Clive P.; Lehmann, Fredrik; Gudjonsson, Thorarinn; Ingthorsson, Saevar (Springer Science and Business Media LLC, 2020-09-10)
    Background: The airway epithelium (AE) forms the first line of defence against harmful particles and pathogens. Barrier failure of the airway epithelium contributes to exacerbations of a range of lung diseases that are commonly treated with Azithromycin ...
  • Arason, Ari Jon; Jóelsson, Jón Pétur; Valdimarsdóttir, Bryndís; Sigurdsson, Snaevar; Guðjónsson, Alexander; Halldorsson, Skarphedinn; Jóhannsson, Freyr; Rolfsson, Óttar; Lehmann, Fredrik; Ingthorsson, Saevar; Cherek, Paulina; Gudmundsson, Gudmundur H; Garðarsson, Friðrik R.; Page, Clive P.; Baldursson, Ólafur; Gudjonsson, Thorarinn; Kricker, Jennifer (Springer Science and Business Media LLC, 2019-06-24)
    BACKGROUND: Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
  • Hilmarsdóttir, Bylgja; Briem, Eiríkur; Halldórsson, Skarphéðinn; Kricker, Jennifer; Ingthorsson, Saevar; Gústafsdóttir, Sigrún; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2017-05-11)
    Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
  • Schepsky, Alexander; Traustadóttir, Gunnhildur Ásta; Jóelsson, Jón Pétur; Ingþórsson, Sævar; Kricker, Jennifer; Bergthorsson, Jon Thor; Ásbjarnarson, Árni; Gudjonsson, Thorkell; Nupponen, Nina; Slipicevic, Ana; Lehmann, Fredrik; Gudjonsson, Thorarinn (Wiley, 2020-07-27)
    Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...
  • Briem, Eiríkur; Budkova, Zuzana; Sigurðardóttir, Anna Karen; Hilmarsdóttir, Bylgja; Kricker, Jennifer; Timp, Winston; Magnusson, Magnus Karl; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn (Elsevier BV, 2019-02)
    MicroRNAs regulate developmental events such as branching morphogenesis, epithelial to mesenchymal transition (EMT) and its reverse process mesenchymal to epithelial transition (MET). In this study, we performed small RNA sequencing of a breast epithelial ...
  • Morera, Erika; Steinhäuser, Sarah Sophie; Budkova, Zuzana; Ingthorsson, Saevar; Kricker, Jennifer; Krueger, Aileen; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn (Springer Science and Business Media LLC, 2019-09-03)
    Epithelial to mesenchymal transition (EMT) is a developmental event that is hijacked in some diseases such as fibrosis and cancer. In cancer, EMT has been linked to increased invasion and metastasis and is generally associated with a poor prognosis. ...