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Browsing by Author "Steingrímsson, Eiríkur"

Browsing by Author "Steingrímsson, Eiríkur"

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    BRN2 is a non-canonical melanoma tumor-suppressor 
    Hamm, Michael; Sohier, Pierre; Petit, Valérie; Raymond, Jérémy H.; Delmas, Véronique; Le Coz, Madeleine; Gesbert, Franck; Kenny, Colin; Aktary, Zackie; Pouteaux, Marie; Rambow, Florian; Sarasin, Alain; Charoenchon, Nisamanee; Bellacosa, Alfonso; Sanchez-del-Campo, Luis; Mosteo, Laura; Lauss, Martin; Meijer, Dies; Steingrímsson, Eiríkur; Jönsson, Göran B.; Cornell, Robert A.; Davidson, Irwin; Goding, Colin R.; Larue, Lionel (2021-06-17)
    While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling ...
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    Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif 
    Pogenberg, Vivian; Ballesteros-Álvarez, Josué; Schober, Romana; Sigvaldadóttir, Ingibjörg; Obarska-Kosinska, Agnieszka; Milewski, Morlin; Schindl, Rainer; Ögmundsdóttir, Margrét Helga; Steingrímsson, Eiríkur; Wilmanns, Matthias (2020-01-24)
    Interrupted dimeric coiled coil segments are found in a broad range of proteins and generally confer selective functional properties such as binding to specific ligands. However, there is only one documented case of a basic-helix-loop-helix leucine ...
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    TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes 
    Kenny, Colin; Dilshat, Ramile; Seberg, Hannah E.; Van Otterloo, Eric; Bonde, Gregory; Helverson, Annika; Franke, Christopher M.; Steingrímsson, Eiríkur; Cornell, Robert A. (2022-05-17)
    In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of genes encoding pigmentation regulators, but their interaction with ...