Koenig, Mary Kay; Russo, Sam Nick; McBride, Kim L.; Björnsson, Hans Tómas; Gunnarsdottir, Brynja Bjork; Goldstein, Amy; Falk, Scott A.
(2023-01)
Several mitochondrial diseases are caused by pathogenic variants that impair membrane phospholipid remodeling, with no FDA-approved therapies. Elamipretide targets the inner mitochondrial membrane where it binds to cardiolipin, resulting in improved ...