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Browsing by Author "Lund, Sigrun H."

Browsing by Author "Lund, Sigrun H."

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    The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements : A Large-Scale Proteomics Scan in Iceland 
    Styrkarsdottir, Unnur; Lund, Sigrun H.; Sævarsdóttir, Sædís; Magnusson, Magnus I.; Gunnarsdottir, Kristbjorg; Norddahl, Gudmundur L.; Frigge, Michael L.; Ivarsdottir, Erna V.; Bjornsdottir, Gyda; Holm, Hilma; Thorgeirsson, Gudmundur; Rafnar, Thorunn; Jónsdóttir, Ingileif; Ingvarsson, Þorvaldur; Jónsson, Helgi; Sulem, Patrick; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Stefansson, Kari (2021-11)
    Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using ...
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    Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland 
    Jonsson, Arnar J.; Lund, Sigrun H.; Eriksen, Bjorn O.; Palsson, Runolfur; Indriðason, Ólafur Skúli (2022-07)
    Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based on multiple markers of kidney damage. Methods: All serum ...
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    Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset 
    Saevarsdottir, Saedis; Stefansdottir, Lilja; Sulem, Patrick; Thorleifsson, Gudmar; Ferkingstad, Egil; Rutsdottir, Gudrun; Glintborg, Bente; Westerlind, Helga; Grondal, Gerdur; Loft, Isabella C.; Sorensen, Signe Bek; Lie, Benedicte A.; Brink, Mikael; Arlestig, Lisbeth; Arnthorsson, Asgeir Orn; Baecklund, Eva; Banasik, Karina; Bank, Steffen; Bjorkman, Lena I.; Ellingsen, Torkell; Erikstrup, Christian; Frei, Oleksandr; Gjertsson, Inger; Gudbjartsson, Daniel F.; Gudjonsson, Sigurjon A.; Halldorsson, Gisli H.; Hendricks, Oliver; Hillert, Jan; Hogdall, Estrid; Jacobsen, Søren; Jensen, Dorte Vendelbo; Jonsson, Helgi; Kastbom, Alf; Kockum, Ingrid; Kristensen, Salome; Kristjansdottir, Helga; Larsen, Margit H.; Linauskas, Asta; Hauge, Ellen Margrethe; Loft, Anne G.; Ludviksson, Bjorn R.; Lund, Sigrun H.; Markusson, Thorsteinn; Masson, Gisli; Melsted, Pall; Moore, Kristjan H.S.; Munk, Heidi; Nielsen, Kaspar R.; Norddahl, Gudmundur L.; Oddsson, Asmundur; Olafsdottir, Thorunn A.; Olason, Pall I.; Olsson, Tomas; Ostrowski, Sisse Rye; Hørslev-Petersen, Kim; Rognvaldsson, Solvi; Sanner, Helga; Silberberg, Gilad N.; Stefansson, Hreinn; Sørensen, Erik; Sørensen, Inge J.; Turesson, Carl; Bergman, Thomas; Alfredsson, Lars; Kvien, Tore K.; Brunak, Søren; Steinsson, Kristján; Andersen, Vibeke; Andreassen, Ole A.; Rantapää-Dahlqvist, Solbritt; Hetland, Merete Lund; Klareskog, Lars; Askling, Johan; Padyukov, Leonid; Pedersen, Ole B.V.; Thorsteinsdottir, Unnur; Jonsdottir, Ingileif; Stefansson, Kari; Saevarsdottir, Saedis (2022-08-01)
    Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ∼1 million ...
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    Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects 
    Teitsdottir, Unnur D.; Darreh-Shori, Taher; Lund, Sigrun H.; Jonsdottir, Maria K.; Snaedal, Jon; Petersen, Petur H. (2022-05-26)
    Background: Cholinergic drugs are the most commonly used drugs for the treatment of Alzheimer's disease (AD). Therefore, a better understanding of the cholinergic system and its relation to both AD-related biomarkers and cognitive functions is of high ...
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    Predicting the probability of death using proteomics 
    Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...