Browsing by Author "Thorsdottir, Sigrun"

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Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice

Aradóttir Pind, Auður Anna; Dubik, Magdalena; Þórsdóttir, Sigrún; Meinke, Andreas; Harandi, Ali M.; Holmgren, Jan; Del Giudice, Giuseppe; Jonsdottir, Ingileif; Bjarnarson, Stefanía P (Frontiers Media SA, 2019-09-26)

Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited due to poorly developed follicular dendritic cells (FDC), causing generation of few antibody-secreting cells (ASCs) with ...
A comparative study of adjuvants effects on neonatal plasma cell survival niche in bone marrow and persistence of humoral immune responses

Pind, Auður Anna Aradóttir; Thorsdottir, Sigrun; Magnusdottir, Gudbjorg Julia; Meinke, Andreas; Del Giudice, Giuseppe; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2022-08-03)

The neonatal immune system is distinct from the immune system of older individuals rendering neonates vulnerable to infections and poor responders to vaccination. Adjuvants can be used as tools to enhance immune responses to co-administered antigens. ...

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